| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | I Now Pronounce You Chuck & Larry | $1,249,268 | - | 350 | - | $3,569 | $1,249,268 | 1 | Universal Pictures International (UPI) | true | false |
| 2 | 1 | Resident Evil: Extinction | $1,189,809 | -44.7% | 350 | - | $3,399 | $4,318,144 | 2 | Sony Pictures Releasing | false | false |
| 3 | 2 | Underdog | $901,730 | -13.7% | 350 | +60 | $2,576 | $2,281,080 | 2 | Walt Disney Pictures | false | false |
| 4 | - | The Invasion | $593,685 | - | 300 | - | $1,978 | $593,685 | 1 | Warner Bros. | true | false |
| 5 | 3 | Stardust | $415,939 | -29.8% | 267 | -43 | $1,557 | $3,971,284 | 4 | Universal Pictures International (UPI) | false | false |
| 6 | 4 | The Bourne Ultimatum | $249,476 | -54.2% | 273 | -89 | $913 | $4,475,868 | 4 | Universal Pictures International (UPI) | false | false |
| 7 | 6 | Next | $130,352 | -43.9% | 144 | -43 | $905 | $3,923,393 | 7 | Paramount Pictures International | false | false |
| 8 | 5 | Rush Hour 3 | $130,146 | -56% | 177 | -101 | $735 | $3,404,228 | 5 | Gussi Films | false | false |
| 9 | 10 | Knocked Up | $118,604 | -5.1% | 123 | +13 | $964 | $1,824,380 | 6 | Universal Pictures International (UPI) | false | false |
| 10 | 7 | Bratz | $113,359 | -43.6% | 136 | -36 | $833 | $714,117 | 3 | Videocine | false | false |
| 11 | 12 | Lovewrecked | $90,207 | -12.1% | 98 | -2 | $920 | $992,717 | 7 | Videocine | false | false |
| 12 | 9 | Mr. Brooks | $79,229 | -41.4% | 81 | -21 | $978 | $2,312,631 | 8 | Videocine | false | false |
| 13 | 15 | Whisper | $63,774 | +9.4% | 66 | +1 | $966 | $1,342,624 | 10 | Gussi Films | false | false |
| 14 | 8 | Surf's Up | $55,318 | -60.5% | 101 | -161 | $547 | $5,686,867 | 8 | Sony Pictures Releasing | false | false |
| 15 | - | The Black Pimpernel | $48,387 | - | 50 | - | $967 | $48,387 | 1 | Gussi Films | true | false |
| 16 | 11 | Vacancy | $46,320 | -61.2% | 79 | -69 | $586 | $1,881,722 | 7 | Sony Pictures Releasing | false | false |
| 17 | 13 | License to Wed | $35,603 | -59.9% | 39 | -41 | $912 | $4,836,620 | 8 | Warner Bros. | false | false |
| 18 | 19 | Firehouse Dog | $32,201 | -10.1% | 37 | -51 | $870 | $585,170 | 5 | 20th Century Fox International | false | false |
| 19 | 17 | The Abandoned | $31,148 | -34.4% | 67 | -25 | $464 | $688,090 | 6 | Videocine | false | false |
| 20 | 18 | The Last Time | $26,586 | -39.3% | 58 | -12 | $458 | $417,753 | 6 | Quality Films | false | false |
| 21 | 14 | The Contract | $22,216 | -63.4% | 22 | -28 | $1,009 | $240,411 | 3 | Gussi Films | false | false |
| 22 | 16 | Unknown | $21,155 | -63.2% | 40 | -20 | $528 | $329,892 | 5 | Videocine | false | false |
| 23 | 25 | Alpha Dog | $17,881 | +9.8% | 26 | +2 | $687 | $356,040 | 9 | Gussi Films | false | false |
| 24 | 21 | Code Name: The Cleaner | $16,649 | -49% | 44 | -11 | $378 | $224,968 | 6 | Videocine | false | false |
| 25 | - | The Lookout | $16,562 | - | 20 | - | $828 | $16,562 | 1 | Walt Disney Pictures | true | false |
| 26 | 24 | Lonely Hearts | $15,257 | -20.1% | 27 | +1 | $565 | $354,955 | 11 | Gussi Films | false | false |
| 27 | 23 | The Butterfly Effect 2 | $11,257 | -57.5% | 23 | -15 | $489 | $295,071 | 6 | Gussi Films | false | false |
| 28 | 31 | After the Wedding | $8,001 | +0.5% | 6 | - | $1,333 | $127,969 | 7 | Gussi Films | false | false |
| 29 | 20 | Hairspray | $7,416 | -77.8% | 15 | -29 | $494 | $1,803,672 | 8 | Gussi Films | false | false |
| 30 | 26 | The Namesake | $6,852 | -52.5% | 5 | -6 | $1,370 | $88,345 | 4 | 20th Century Fox International | false | false |
| 31 | 22 | Evan Almighty | $6,310 | -76.9% | 10 | -34 | $631 | $5,620,996 | 9 | Universal Pictures International (UPI) | false | false |
| 32 | 27 | The Hitcher | $5,363 | -54.9% | 18 | -29 | $297 | $106,049 | 3 | Gussi Films | false | false |
| 33 | 29 | The Night Buffalo | $4,186 | -62.6% | 11 | -11 | $380 | $1,469,229 | 7 | 20th Century Fox International | false | false |
| 34 | 33 | Reign Over Me | $2,136 | -21.6% | 7 | +2 | $305 | $287,863 | 16 | Sony Pictures Releasing | false | false |
| 35 | 28 | No Reservations | $1,997 | -82.3% | 4 | -4 | $499 | $2,858,816 | 10 | Warner Bros. | false | false |
| 36 | 32 | Breach | $915 | -79% | 3 | -9 | $305 | $1,020,455 | 6 | Azteca Films | false | false |
| 37 | 35 | Hostel: Part II | $93 | -61.7% | 2 | - | $46 | $617,418 | 10 | Sony Pictures Releasing | false | false |
