| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Pirates of the Caribbean: At World's End | $5,116,464 | -31.5% | 878 | -31 | $5,827 | $17,097,460 | 2 | Buena Vista International | false | false |
| 2 | - | Death Proof | $1,179,634 | - | 343 | - | $3,439 | $1,179,634 | 1 | Medusa Distribuzione | true | false |
| 3 | 2 | Spider-Man 3 | $771,221 | -21.2% | 273 | -186 | $2,824 | $23,515,663 | 5 | Sony Pictures Releasing | false | false |
| 4 | 3 | Zodiac | $586,844 | -10.9% | 214 | -15 | $2,742 | $2,704,979 | 3 | Warner Bros. | false | false |
| 5 | 4 | Curse of the Golden Flower | $515,341 | +14.5% | 153 | -2 | $3,368 | $1,184,428 | 2 | 01 Distribution | false | false |
| 6 | - | Turistas | $390,008 | - | 126 | - | $3,095 | $390,008 | 1 | 01 Distribution | true | false |
| 7 | - | Cardiofitness | $262,587 | - | 145 | - | $1,810 | $262,625 | 1 | 01 Distribution | true | false |
| 8 | - | The Namesake | $172,272 | - | 50 | - | $3,445 | $172,272 | 1 | 20th Century Fox International | true | false |
| 9 | 6 | My Brother is an Only Child | $155,039 | +1.4% | 49 | -24 | $3,164 | $7,992,956 | 7 | Warner Bros. | false | false |
| 10 | 9 | The Lives of Others | $147,179 | +10.6% | 41 | -17 | $3,589 | $3,898,866 | 9 | 01 Distribution | false | false |
| 11 | 5 | Man of the Year | $120,436 | -52.2% | 66 | -100 | $1,824 | $1,790,137 | 4 | Medusa Distribuzione | false | false |
| 12 | 7 | Night Bus | $117,173 | -18.8% | 57 | -60 | $2,055 | $1,201,873 | 4 | 01 Distribution | false | false |
| 13 | - | The Ugly Duckling and Me! | $109,526 | - | 50 | - | $2,190 | $109,526 | 1 | Eagle Pictures | true | false |
| 14 | 10 | Breakfast on Pluto | $104,587 | -8.7% | 58 | -24 | $1,803 | $289,035 | 2 | Fandango | false | false |
| 15 | - | The Darwin Awards | $102,358 | - | 54 | - | $1,895 | $102,358 | 1 | Moviemax | true | false |
| 16 | 12 | Four Minutes | $94,215 | +22.1% | 42 | -1 | $2,243 | $674,250 | 5 | Lady Film | false | false |
| 17 | 11 | The Good Shepherd | $69,247 | -39.3% | 32 | - | $2,163 | $3,957,140 | 7 | Medusa Distribuzione | false | false |
| 18 | 8 | Breach | $46,904 | -65.8% | 39 | -84 | $1,202 | $525,409 | 3 | Mikado Film | false | false |
| 19 | - | Terapia Roosevelt | $46,699 | - | 23 | - | $2,030 | $46,699 | 1 | Independent Films | true | false |
| 20 | 14 | La Vie En Rose | $45,232 | -27.6% | 20 | -33 | $2,261 | $1,134,560 | 5 | Mikado Film | false | false |
| 21 | 17 | A Dream House Nightmare | $38,560 | -8.7% | 12 | -5 | $3,213 | $1,136,848 | 8 | Moviemax | false | false |
| 22 | 19 | One Hundred Nails | $27,085 | -16.4% | 15 | -13 | $1,805 | $3,053,332 | 10 | Mikado Film | false | false |
| 23 | 16 | Me, the Other | $20,894 | -57.9% | 29 | -27 | $720 | $217,984 | 3 | 20th Century Fox International | false | false |
| 24 | - | The Illusionist | $18,712 | - | 2 | - | $9,356 | $3,206,571 | 9 | Eagle Pictures | false | false |
| 25 | - | The U.S. vs. John Lennon | $12,890 | - | 9 | - | $1,432 | $12,890 | 1 | Mikado Film | true | false |
| 26 | 35 | The Wind Blows Round | $12,337 | +279% | 6 | +4 | $2,056 | $58,889 | 5 | Aranciafilm | false | false |
| 27 | - | Shan: The Ancient Heart of Natural People | $10,551 | - | 3 | - | $3,517 | $32,315 | 11 | N/A | false | false |
| 28 | 33 | Ghost Son | $9,515 | +173% | 4 | +1 | $2,378 | $193,922 | 5 | Moviemax | false | false |
| 29 | 15 | The Number 23 | $8,690 | -82.7% | 6 | -29 | $1,448 | $4,024,343 | 6 | 01 Distribution | false | false |
| 30 | 18 | Epic Movie | $8,641 | -79.4% | 13 | -32 | $664 | $4,138,092 | 6 | 20th Century Fox International | false | false |
| 31 | 24 | Le ferie di Licu | $8,272 | -1.1% | 5 | - | $1,654 | $73,586 | 5 | Independent Films | false | false |
| 32 | 26 | Climates | $6,255 | +7% | 2 | -1 | $3,127 | $110,924 | 7 | BIM Distribuzione | false | false |
| 33 | 20 | The Hills Have Eyes 2 | $6,164 | -78.3% | 15 | -29 | $410 | $617,750 | 4 | 20th Century Fox International | false | false |
| 34 | - | Pirates of the Caribbean: Dead Man's Chest | $5,801 | - | 2 | - | $2,900 | $25,212,003 | 38 | Buena Vista International | false | false |
| 35 | 31 | The Lark Farm | $5,537 | +29% | 4 | -2 | $1,384 | $951,913 | 11 | 01 Distribution | false | false |
| 36 | 13 | Prey | $4,939 | -93.6% | 9 | -105 | $548 | $325,223 | 3 | Eagle Pictures | false | false |
| 37 | 21 | Wild Hogs | $4,738 | -77.1% | 4 | -15 | $1,184 | $4,024,291 | 7 | Buena Vista International | false | false |
| 38 | 40 | Flying Lessons | $4,671 | +112.6% | 4 | - | $1,167 | $2,197,582 | 12 | 01 Distribution | false | false |
| 39 | 36 | Still Life | $4,262 | +31.3% | 4 | -1 | $1,065 | $391,607 | 11 | Lucky Red | false | false |
| 40 | 25 | Goya's Ghosts | $3,765 | -42.8% | 5 | -5 | $753 | $1,198,992 | 8 | Medusa Distribuzione | false | false |
| 41 | 37 | Sketches of Frank Gehry | $3,374 | +16.6% | 5 | -1 | $674 | $205,170 | 10 | BIM Distribuzione | false | false |
| 42 | 23 | Il punto rosso | $2,937 | -68.8% | 5 | -4 | $587 | $21,273 | 2 | Independent Films | false | false |
| 43 | 34 | Quatre étoiles | $2,754 | -15.7% | 2 | -2 | $1,377 | $59,810 | 4 | BIM Distribuzione | false | false |
| 44 | 48 | Notes on a Scandal | $2,514 | +137.2% | 2 | - | $1,257 | $1,808,097 | 15 | 20th Century Fox International | false | false |
| 45 | 29 | Dry Season | $2,439 | -55.2% | 2 | -2 | $1,219 | $11,806 | 2 | Lucky Red | false | false |
| 46 | 28 | Tutte le donne della mia vita | $2,338 | -58% | 2 | -2 | $1,169 | $1,086,435 | 8 | Eagle Pictures | false | false |
| 47 | 30 | Voce del verbo amore | $1,979 | -60.5% | 2 | -5 | $989 | $1,062,488 | 6 | Medusa Distribuzione | false | false |
| 48 | - | Death of a President | $1,440 | - | 3 | - | $480 | $164,858 | 12 | Lucky Red | false | false |
| 49 | - | The Painted Veil | $1,370 | - | 2 | - | $685 | $584,907 | 15 | Eagle Pictures | false | false |
| 50 | - | Night at the Museum | $1,343 | - | 2 | - | $671 | $15,399,789 | 18 | 20th Century Fox International | false | false |
