| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | 300 | $132,722 | -34.2% | 86 | +14 | $1,543 | $3,563,396 | 5 | Warner Bros. | false | false |
| 2 | 4 | The Lives of Others | $115,644 | -7% | 21 | - | $5,506 | $278,215 | 2 | Alfa Films | false | false |
| 3 | 3 | Perfect Stranger | $88,459 | -35.6% | 50 | - | $1,769 | $478,071 | 3 | Sony Pictures Releasing | false | false |
| 4 | 2 | Meet the Robinsons | $84,156 | -47.9% | 101 | -7 | $833 | $1,619,940 | 5 | Buena Vista International | false | false |
| 5 | - | The Messengers | $75,163 | - | 29 | - | $2,591 | $75,163 | 1 | Alfa Films | true | false |
| 6 | 5 | Disturbia | $50,062 | -49.1% | 30 | - | $1,668 | $172,609 | 2 | United International Pictures | false | false |
| 7 | 7 | Wild Hogs | $44,239 | -34.5% | 41 | - | $1,079 | $237,309 | 3 | Buena Vista International | false | false |
| 8 | 10 | The Number 23 | $41,892 | -4.8% | 27 | - | $1,551 | $633,131 | 6 | Distribution Company | false | false |
| 9 | 6 | Happily N'Ever After | $38,601 | -51.9% | 33 | - | $1,169 | $136,316 | 2 | Distribution Company | false | false |
| 10 | 8 | Trust the Man | $30,747 | -48.7% | 21 | - | $1,464 | $101,104 | 2 | Pachamama Cine | false | false |
| 11 | 11 | Music and Lyrics | $28,783 | -33.9% | 31 | +1 | $928 | $767,353 | 7 | Warner Bros. | false | false |
| 12 | 14 | Shooter | $20,920 | -30.4% | 30 | - | $697 | $218,688 | 4 | United International Pictures | false | false |
| 13 | 15 | El amor y la ciudad | $19,021 | -31.9% | 11 | -5 | $1,729 | $53,270 | 2 | Primer Plano Film Group | false | false |
| 14 | 12 | TMNT | $18,916 | -46.4% | 50 | -1 | $378 | $267,875 | 4 | Distribution Company | false | false |
| 15 | 9 | Sunshine | $18,691 | -60.2% | 20 | - | $934 | $77,392 | 2 | 20th Century Fox International | false | false |
| 16 | 25 | Pathfinder | $14,226 | +122.1% | 15 | +4 | $948 | $162,105 | 6 | 20th Century Fox International | false | false |
| 17 | - | Kept and Dreamless | $8,722 | - | 13 | - | $670 | $8,722 | 1 | Primer Plano Film Group | true | false |
| 18 | 16 | Scoop | $8,649 | -60.7% | 13 | -4 | $665 | $363,235 | 6 | CDI Films | false | false |
| 19 | 33 | Notes on a Scandal | $8,600 | +291.6% | 13 | +6 | $661 | $194,218 | 8 | 20th Century Fox International | false | false |
| 20 | 19 | Epic Movie | $7,410 | -46.2% | 14 | -4 | $529 | $176,588 | 5 | 20th Century Fox International | false | false |
| 21 | 18 | Paris, Je T'aime | $6,436 | -57.1% | 10 | -5 | $643 | $274,523 | 7 | Impacto Cine | false | false |
| 22 | 23 | The Queen | $6,425 | -22.8% | 20 | +2 | $321 | $825,500 | 10 | Distribution Company | false | false |
| 23 | 17 | Arthur and the Invisibles | $5,838 | -65.2% | 35 | -4 | $166 | $111,777 | 4 | Alfa Films | false | false |
| 24 | 35 | The Education of Fairies | $5,560 | +248.8% | 14 | +5 | $397 | $80,671 | 5 | Buena Vista International | false | false |
| 25 | 21 | Who Says It's Easy? | $4,861 | -50.2% | 16 | -6 | $303 | $1,283,098 | 12 | Primer Plano Film Group | false | false |
| 26 | 22 | Apocalypto | $4,142 | -51.4% | 19 | -7 | $218 | $835,469 | 13 | 20th Century Fox International | false | false |
| 27 | - | The Aerial | $3,733 | - | 5 | - | $746 | $14,212 | 2 | Pachamama Cine | false | false |
| 28 | 24 | Ghost Rider | $3,469 | -57.6% | 20 | -7 | $173 | $558,942 | 7 | Sony Pictures Releasing | false | false |
| 29 | 27 | Stranger Than Fiction | $3,427 | -18% | 12 | +6 | $285 | $176,602 | 8 | Sony Pictures Releasing | false | false |
| 30 | 36 | Hoodwinked! | $3,108 | +158.4% | 12 | +2 | $259 | $812,364 | 12 | Alfa Films | false | false |
| 31 | 39 | Captain Alatriste: The Spanish Musketeer | $2,831 | +341% | 9 | +7 | $314 | $34,903 | 4 | 20th Century Fox International | false | false |
| 32 | 41 | See No Evil | $2,449 | +468.2% | 11 | +10 | $222 | $70,333 | 10 | Alfa Films | false | false |
| 33 | 28 | Blood Diamond | $2,304 | -41.4% | 8 | -2 | $288 | $884,642 | 12 | Warner Bros. | false | false |
| 34 | 26 | Letters from Iwo Jima | $1,566 | -75.5% | 11 | -1 | $142 | $304,179 | 11 | Warner Bros. | false | false |
| 35 | 48 | Night at the Museum | $1,350 | +837.5% | 4 | - | $337 | $3,212,057 | 15 | 20th Century Fox International | false | false |
| 36 | 32 | Rocky Balboa | $1,220 | -51.5% | 8 | -7 | $152 | $407,049 | 9 | 20th Century Fox International | false | false |
| 37 | 31 | Norbit | $860 | -66.1% | 4 | -8 | $215 | $242,627 | 8 | United International Pictures | false | false |
| 38 | 37 | Funny Ha Ha 2007 Re-release | $562 | -47.7% | 1 | - | $562 | $1,888 | 2 | 791 Cine | false | false |
| 39 | 38 | City in Heat | $447 | -56.9% | 3 | - | $149 | $31,780 | 6 | Alfa Films | false | false |
| 40 | 34 | Babel | $354 | -81.6% | 3 | -6 | $118 | $1,731,395 | 15 | United International Pictures | false | false |
| 41 | 29 | Crank | $335 | -90.1% | 1 | -6 | $335 | $152,210 | 8 | Alfa Films | false | false |
| 42 | 47 | Time to Leave | $331 | +105.6% | 3 | +2 | $110 | $61,595 | 9 | Alfa Films | false | false |
| 43 | 45 | The Good Shepherd | $320 | -2.1% | 2 | - | $160 | $381,638 | 10 | United International Pictures | false | false |
| 44 | 51 | Flushed Away | $315 | +1,557.9% | 3 | +2 | $105 | $1,581,318 | 17 | United International Pictures | false | false |
| 45 | 46 | Happy Feet | $265 | +16.7% | 21 | +17 | $12 | $1,377,903 | 21 | Warner Bros. | false | false |
| 46 | 40 | Charlotte's Web | $213 | -55.6% | 14 | +9 | $15 | $310,456 | 14 | United International Pictures | false | false |
| 47 | 44 | C.R.A.Z.Y. | $180 | -46.1% | 7 | +6 | $25 | $47,835 | 7 | Alfa Films | false | false |
| 48 | 30 | The Last King of Scotland | $139 | -94.9% | 11 | +1 | $12 | $159,204 | 11 | 20th Century Fox International | false | false |
| 49 | - | Perfume: The Story of a Murderer | $134 | - | 11 | - | $12 | $266,292 | 11 | Distribution Company | false | false |
| 50 | 50 | Pura sangre | $47 | -49.5% | 4 | +3 | $11 | $8,825 | 4 | Primer Plano Film Group | false | false |
| 51 | 42 | Flags of Our Fathers | $5 | -98.7% | 1 | -5 | $5 | $207,218 | 14 | Warner Bros. | false | false |
