| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | 300 | $268,584 | - | 64 | - | $4,196 | $3,228,953 | 3 | Warner Bros. | false | false |
| 2 | - | Meet the Robinsons | $190,525 | - | 99 | - | $1,924 | $1,304,292 | 3 | Buena Vista International | false | false |
| 3 | - | Perfect Stranger | $189,165 | - | 50 | - | $3,783 | $189,165 | 1 | Sony Pictures Releasing | true | false |
| 4 | - | Wild Hogs | $94,445 | - | 40 | - | $2,361 | $94,445 | 1 | Buena Vista International | true | false |
| 5 | - | Music and Lyrics | $55,859 | - | 30 | - | $1,861 | $673,630 | 5 | Warner Bros. | false | false |
| 6 | - | TMNT | $53,254 | - | 49 | - | $1,086 | $196,250 | 2 | Distribution Company | false | false |
| 7 | - | The Reaping | $49,810 | - | 33 | - | $1,509 | $175,534 | 2 | Warner Bros. | false | false |
| 8 | - | The Number 23 | $48,983 | - | 27 | - | $1,814 | $527,240 | 4 | Distribution Company | false | false |
| 9 | - | Shooter | $38,608 | - | 30 | - | $1,286 | $150,894 | 2 | United International Pictures | false | false |
| 10 | - | Scoop | $27,409 | - | 23 | - | $1,191 | $322,398 | 4 | CDI Films | false | false |
| 11 | - | Arthur and the Invisibles | $23,928 | - | 43 | - | $556 | $83,765 | 2 | Alfa Films | false | false |
| 12 | - | Who Says It's Easy? | $19,566 | - | 27 | - | $724 | $1,262,207 | 10 | Primer Plano Film Group | false | false |
| 13 | - | Paris, Je T'aime | $19,473 | - | 14 | - | $1,390 | $243,897 | 5 | Impacto Cine | false | false |
| 14 | - | Epic Movie | $15,611 | - | 20 | - | $780 | $149,631 | 3 | 20th Century Fox International | false | false |
| 15 | - | The Queen | $14,559 | - | 21 | - | $693 | $802,945 | 8 | Distribution Company | false | false |
| 16 | - | Apocalypto | $12,043 | - | 26 | - | $463 | $812,500 | 11 | 20th Century Fox International | false | false |
| 17 | - | Pathfinder | $11,860 | - | 14 | - | $847 | $135,081 | 4 | 20th Century Fox International | false | false |
| 18 | - | Ghost Rider | $11,091 | - | 38 | - | $291 | $541,676 | 5 | Sony Pictures Releasing | false | false |
| 19 | - | The Wicker Man | $8,797 | - | 19 | - | $463 | $199,060 | 6 | Distribution Company | false | false |
| 20 | - | Norbit | $7,237 | - | 18 | - | $402 | $235,820 | 6 | United International Pictures | false | false |
| 21 | - | Letters from Iwo Jima | $6,674 | - | 13 | - | $513 | $292,552 | 9 | Warner Bros. | false | false |
| 22 | - | The Education of Fairies | $6,316 | - | 18 | - | $350 | $71,466 | 3 | Buena Vista International | false | false |
| 23 | - | Blood Diamond | $5,603 | - | 12 | - | $466 | $875,418 | 10 | Warner Bros. | false | false |
| 24 | - | Rocky Balboa | $5,191 | - | 22 | - | $235 | $181,294 | 7 | 20th Century Fox International | false | false |
| 25 | - | Notes on a Scandal | $4,778 | - | 9 | - | $530 | $181,294 | 6 | 20th Century Fox International | false | false |
| 26 | - | Captain Alatriste: The Spanish Musketeer | $4,453 | - | 15 | - | $296 | $30,075 | 2 | 20th Century Fox International | false | false |
| 27 | - | Babel | $3,856 | - | 21 | - | $183 | $1,726,113 | 13 | United International Pictures | false | false |
| 28 | - | Hoodwinked! | $3,809 | - | 21 | - | $181 | $806,196 | 10 | Alfa Films | false | false |
| 29 | - | The Last King of Scotland | $2,619 | - | 8 | - | $327 | $154,843 | 9 | 20th Century Fox International | false | false |
| 30 | - | Pura sangre | $2,240 | - | 4 | - | $560 | $7,943 | 2 | Primer Plano Film Group | false | false |
| 31 | - | Pan's Labyrinth | $1,354 | - | 5 | - | $270 | $187,128 | 15 | Warner Bros. | false | false |
| 32 | - | Night at the Museum | $1,138 | - | 8 | - | $142 | $3,210,563 | 13 | 20th Century Fox International | false | false |
| 33 | - | Perfume: The Story of a Murderer | $886 | - | 5 | - | $177 | $265,348 | 9 | Distribution Company | false | false |
| 34 | - | The Holiday | $797 | - | 1 | - | $797 | $674,491 | 14 | United International Pictures | false | false |
| 35 | - | Flags of Our Fathers | $680 | - | 6 | - | $113 | $206,166 | 12 | Warner Bros. | false | false |
| 36 | - | Crank | $556 | - | 2 | - | $278 | $147,197 | 6 | Alfa Films | false | false |
| 37 | - | City in Heat | $524 | - | 2 | - | $262 | $29,945 | 4 | Alfa Films | false | false |
| 38 | - | Time to Leave | $461 | - | 2 | - | $230 | $60,907 | 7 | Alfa Films | false | false |
| 39 | - | See No Evil | $440 | - | 1 | - | $440 | $64,911 | 8 | Alfa Films | false | false |
| 40 | - | The Departed | $432 | - | 2 | - | $216 | $2,011,479 | 22 | Warner Bros. | false | false |
| 41 | - | The Good Shepherd | $432 | - | 2 | - | $216 | $361,840 | 8 | United International Pictures | false | false |
| 42 | - | The Bow | $373 | - | 1 | - | $373 | $34,340 | 12 | Alfa Films | false | false |
| 43 | - | C.R.A.Z.Y. | $348 | - | 2 | - | $174 | $46,598 | 5 | Alfa Films | false | false |
| 44 | - | Charlotte's Web | $295 | - | 3 | - | $98 | $298,064 | 12 | United International Pictures | false | false |
| 45 | - | Happy Feet | $294 | - | 3 | - | $98 | $1,377,238 | 19 | Warner Bros. | false | false |
| 46 | - | Stranger Than Fiction | $286 | - | 1 | - | $286 | $167,778 | 6 | Sony Pictures Releasing | false | false |
| 47 | - | Flushed Away | $211 | - | 3 | - | $70 | $1,580,984 | 15 | United International Pictures | false | false |
| 48 | - | A Movie of Eggs | $197 | - | 2 | - | $98 | $43,607 | 14 | Warner Bros. | false | false |
| 49 | - | Dragones: destino de fuego | $19 | - | 3 | - | $6 | $86,002 | 11 | Pachamama Cine | false | false |
