| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Blades of Glory | $25,327,019 | - | 3,410 | - | $7,427 | $70,709,926 | 2 | DreamWorks | false | false |
| 2 | - | Meet the Robinsons | $19,586,915 | - | 3,435 | - | $5,702 | $54,818,749 | 2 | Walt Disney Studios Motion Pictures | false | false |
| 3 | - | Are We Done Yet? | $16,317,882 | - | 2,877 | - | $5,671 | $20,572,175 | 1 | Revolution Studios | true | false |
| 4 | - | Grindhouse | $12,857,851 | - | 2,624 | - | $4,900 | $12,857,851 | 1 | Dimension Films | true | false |
| 5 | - | The Reaping | $11,057,543 | - | 2,603 | - | $4,247 | $12,990,858 | 1 | Warner Bros. | true | false |
| 6 | - | 300 | $9,346,823 | - | 2,674 | - | $3,495 | $194,380,900 | 5 | Warner Bros. | false | false |
| 7 | - | Wild Hogs | $7,346,503 | - | 2,825 | - | $2,600 | $145,962,098 | 6 | Walt Disney Studios Motion Pictures | false | false |
| 8 | - | Shooter | $6,537,222 | - | 2,353 | - | $2,778 | $37,392,804 | 3 | Paramount Pictures | false | false |
| 9 | - | TMNT | $5,547,876 | - | 2,811 | - | $1,973 | $47,329,762 | 3 | Warner Bros. | false | false |
| 10 | - | Firehouse Dog | $4,561,558 | - | 2,860 | - | $1,594 | $5,824,549 | 1 | Twentieth Century Fox | true | false |
| 11 | - | Premonition | $3,455,999 | - | 1,752 | - | $1,972 | $44,875,270 | 4 | Sony Pictures Releasing | false | false |
| 12 | - | Reign Over Me | $2,715,563 | - | 1,747 | - | $1,554 | $17,611,895 | 3 | Sony Pictures Releasing | false | false |
| 13 | - | The Namesake | $1,858,466 | - | 335 | - | $5,547 | $7,025,278 | 5 | Fox Searchlight Pictures | false | false |
| 14 | - | The Last Mimzy | $1,792,000 | - | 2,104 | - | $851 | $19,111,000 | 3 | New Line Cinema | false | true |
| 15 | - | The Hills Have Eyes 2 | $1,758,660 | - | 1,169 | - | $1,504 | $19,338,242 | 3 | Fox Atomic | false | false |
| 16 | - | The Hoax | $1,583,000 | - | 235 | - | $6,736 | $1,583,000 | 1 | Miramax | true | true |
| 17 | - | The Lookout | $1,139,000 | - | 955 | - | $1,192 | $3,921,000 | 2 | Miramax | false | true |
| 18 | - | Amazing Grace | $717,000 | - | 392 | - | $1,829 | $19,331,000 | 7 | IDP Distribution | false | true |
| 19 | - | The Lives of Others | $659,000 | - | 213 | - | $3,093 | $7,498,000 | 9 | Sony Pictures Classics | false | true |
| 20 | - | Night at the Museum | $618,421 | - | 367 | - | $1,685 | $248,610,582 | 16 | Twentieth Century Fox | false | false |
| 21 | - | Pride | $467,491 | - | 370 | - | $1,263 | $6,706,766 | 3 | Lionsgate | false | false |
| 22 | - | Dead Silence | $458,615 | - | 316 | - | $1,451 | $16,342,580 | 4 | Universal Pictures | false | false |
| 23 | - | Ghost Rider | $450,770 | - | 418 | - | $1,078 | $114,824,199 | 8 | Sony Pictures Releasing | false | false |
| 24 | - | I Think I Love My Wife | $271,544 | - | 168 | - | $1,616 | $12,326,237 | 4 | Fox Searchlight Pictures | false | false |
| 25 | - | Deep Sea | $270,595 | - | 35 | - | $7,731 | $25,991,273 | 58 | Warner Bros. | false | false |
| 26 | - | The Host | $191,000 | - | 101 | - | $1,891 | $1,759,000 | 5 | Magnolia Pictures | false | true |
| 27 | - | Zodiac | $188,126 | - | 130 | - | $1,447 | $32,774,879 | 6 | Paramount Pictures | false | false |
| 28 | - | Pan's Labyrinth | $144,715 | - | 113 | - | $1,280 | $37,172,306 | 15 | Picturehouse | false | false |
| 29 | - | Miss Potter | $143,887 | - | 91 | - | $1,581 | $2,093,030 | 15 | Metro-Goldwyn-Mayer (MGM) | false | false |
| 30 | - | Dreamgirls | $132,305 | - | 220 | - | $601 | $103,209,295 | 17 | DreamWorks | false | false |
| 31 | - | Happy Feet | $127,267 | - | 224 | - | $568 | $197,772,703 | 21 | Warner Bros. | false | false |
| 32 | - | Norbit | $116,094 | - | 202 | - | $574 | $94,783,700 | 9 | DreamWorks | false | false |
| 33 | - | Music and Lyrics | $109,889 | - | 123 | - | $893 | $49,945,913 | 8 | Warner Bros. | false | false |
| 34 | - | Breach | $104,990 | - | 120 | - | $874 | $32,967,845 | 8 | Universal Pictures | false | false |
| 35 | - | The Astronaut Farmer | $100,659 | - | 201 | - | $500 | $10,865,586 | 7 | Warner Bros. | false | false |
| 36 | - | The Last King of Scotland | $78,153 | - | 69 | - | $1,132 | $17,456,728 | 28 | Fox Searchlight Pictures | false | false |
| 37 | - | Journey from the Fall | $73,348 | - | 10 | - | $7,334 | $311,030 | 3 | ImaginAsian Pictures | false | false |
| 38 | - | First Snow | $65,803 | - | 32 | - | $2,056 | $107,075 | 3 | Yari Film Group Releasing | false | false |
| 39 | - | Letters from Iwo Jima | $42,537 | - | 120 | - | $354 | $13,709,538 | 16 | Warner Bros. | false | false |
| 40 | - | Arthur and the Invisibles | $32,903 | - | 83 | - | $396 | $15,069,424 | 15 | Metro-Goldwyn-Mayer (MGM) | false | false |
| 41 | - | The Painted Veil | $32,538 | - | 35 | - | $929 | $7,985,603 | 16 | Warner Independent Pictures (WIP) | false | false |
| 42 | - | Blood Diamond | $28,512 | - | 47 | - | $606 | $57,369,624 | 18 | Warner Bros. | false | false |
| 43 | - | Notes on a Scandal | $28,448 | - | 28 | - | $1,016 | $17,440,988 | 15 | Fox Searchlight Pictures | false | false |
| 44 | - | Epic Movie | $20,374 | - | 36 | - | $565 | $39,702,975 | 11 | Twentieth Century Fox | false | false |
| 45 | - | Reno 911!: Miami | $15,089 | - | 43 | - | $350 | $20,308,215 | 7 | Twentieth Century Fox | false | false |
| 46 | - | Black Snake Moan | $13,458 | - | 19 | - | $708 | $9,289,909 | 6 | Paramount Vantage | false | false |
| 47 | - | The Good German | $8,153 | - | 10 | - | $815 | $1,305,524 | 17 | Warner Bros. | false | false |
| 48 | - | Days of Glory | $7,949 | - | 9 | - | $883 | $302,289 | 18 | The Weinstein Company | false | false |
| 49 | - | Breaking and Entering | $5,592 | - | 7 | - | $798 | $921,015 | 17 | The Weinstein Company | false | false |
| 50 | - | Hannibal Rising | $3,374 | - | 10 | - | $337 | $27,587,276 | 9 | Metro-Goldwyn-Mayer (MGM) | false | false |
| 51 | - | Nomad: The Warrior | $3,296 | - | 14 | - | $235 | $52,193 | 4 | The Weinstein Company | false | false |
| 52 | - | Eragon | $1,761 | - | 8 | - | $220 | $75,030,163 | 17 | Twentieth Century Fox | false | false |
