| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | 300 | $6,712,930 | - | 536 | - | $12,524 | $6,712,930 | 1 | Warner Bros. | true | false |
| 2 | 1 | Hannibal Rising | $905,966 | -47.2% | 325 | - | $2,787 | $3,086,601 | 2 | Aurum Films | false | false |
| 3 | 2 | Norbit | $818,187 | -34% | 249 | +1 | $3,285 | $2,324,600 | 2 | Universal Pictures International (UPI) | false | false |
| 4 | 3 | Epic Movie | $570,383 | -47.5% | 299 | -1 | $1,907 | $3,859,177 | 3 | 20th Century Fox International | false | false |
| 5 | 4 | The Painted Veil | $525,552 | -23.6% | 205 | - | $2,563 | $2,666,713 | 3 | Aurum Films | false | false |
| 6 | 5 | Bridge to Terabithia | $469,806 | -28.9% | 294 | -11 | $1,597 | $4,576,987 | 4 | DeAPlaneta | false | false |
| 7 | 7 | The Lives of Others | $380,563 | -6.5% | 97 | -1 | $3,923 | $3,247,510 | 6 | Alta Films | false | false |
| 8 | 6 | Lola, la película | $346,000 | -41% | 314 | -12 | $1,101 | $1,185,270 | 2 | DeAPlaneta | false | false |
| 9 | - | Impy's Island | $295,927 | - | 100 | - | $2,959 | $295,927 | 1 | Universal Pictures International (UPI) | true | false |
| 10 | 8 | Blood Diamond | $258,186 | -33.5% | 208 | -56 | $1,241 | $8,855,734 | 7 | Warner Bros. | false | false |
| 11 | 9 | Goal II: Living the Dream | $222,152 | -19.4% | 78 | -25 | $2,848 | $555,226 | 2 | Buena Vista International | false | false |
| 12 | - | A Prairie Home Companion | $188,071 | - | 74 | - | $2,541 | $188,071 | 1 | Manga Entertainment | true | false |
| 13 | 10 | The Last King of Scotland | $145,636 | -29.3% | 103 | -4 | $1,413 | $2,043,174 | 5 | 20th Century Fox International | false | false |
| 14 | - | Atlas of Human Geography | $144,932 | - | 74 | - | $1,958 | $144,932 | 1 | Alta Films | true | false |
| 15 | 15 | The Good German | $111,192 | -29.8% | 66 | -5 | $1,684 | $1,080,943 | 4 | Warner Bros. | false | false |
| 16 | 16 | The Departed | $104,046 | -34% | 71 | -26 | $1,465 | $13,638,916 | 22 | Warner Bros. | false | false |
| 17 | 12 | The Pursuit of Happyness | $102,082 | -43.1% | 130 | -54 | $785 | $8,767,321 | 8 | Sony Pictures Releasing | false | false |
| 18 | 14 | Theresa: The Body of Christ | $90,700 | -44.8% | 98 | -2 | $925 | $746,738 | 3 | Azteca Films | false | false |
| 19 | - | The Boss of It All | $86,935 | - | 29 | - | $2,997 | $212,356 | 2 | Golem Distribución | false | false |
| 20 | 13 | Bordertown | $86,816 | -47.6% | 108 | -60 | $803 | $2,735,624 | 5 | TriPictures | false | false |
