| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Bridge to Terabithia | $1,827,294 | - | 304 | - | $6,010 | $1,827,294 | 1 | DeAPlaneta | true | false |
| 2 | 1 | Ghost Rider | $843,591 | -45.2% | 400 | -17 | $2,108 | $6,443,287 | 3 | Sony Pictures Releasing | false | false |
| 3 | 2 | Blood Diamond | $817,137 | -30.5% | 340 | -5 | $2,403 | $7,129,325 | 4 | Warner Bros. | false | false |
| 4 | 3 | The Grudge 2 | $663,560 | -40.1% | 286 | +2 | $2,320 | $2,025,084 | 2 | - | false | false |
| 5 | 4 | Bordertown | $595,859 | -37.4% | 264 | -6 | $2,257 | $1,831,722 | 2 | TriPictures | false | false |
| 6 | 6 | The Pursuit of Happyness | $531,712 | -35.2% | 283 | -6 | $1,878 | $7,837,766 | 5 | Sony Pictures Releasing | false | false |
| 7 | - | The Host | $507,500 | - | 169 | - | $3,002 | $507,500 | 1 | Notro Films | true | false |
| 8 | 10 | The Lives of Others | $505,725 | +36.5% | 83 | +8 | $6,093 | $1,501,519 | 3 | Alta Films | false | false |
| 9 | 5 | Night at the Museum | $472,403 | -43.5% | 319 | -55 | $1,480 | $15,952,609 | 6 | 20th Century Fox International | false | false |
| 10 | 7 | The Last King of Scotland | $448,921 | +0.6% | 110 | +20 | $4,081 | $1,097,478 | 2 | 20th Century Fox International | false | false |
| 11 | - | The Departed | $360,487 | - | 125 | - | $2,883 | $12,762,468 | 19 | Warner Bros. | false | false |
| 12 | - | The Good German | $348,914 | - | 69 | - | $5,056 | $348,914 | 1 | Warner Bros. | true | false |
| 13 | 8 | Babel | $279,641 | -29.8% | 186 | -25 | $1,503 | $13,084,732 | 10 | United International Pictures | false | false |
| 14 | 9 | John Tucker Must Die | $218,860 | -43.7% | 208 | -42 | $1,052 | $2,453,284 | 4 | 20th Century Fox International | false | false |
| 15 | 13 | Pan's Labyrinth | $201,329 | +0.9% | 106 | +7 | $1,899 | $11,125,888 | 21 | Warner Bros. | false | false |
| 16 | 11 | Letters from Iwo Jima | $169,526 | -46.3% | 69 | - | $2,456 | $1,106,398 | 3 | Warner Bros. | false | false |
| 17 | 14 | Paris, Je T'aime | $138,772 | -19.1% | 41 | +1 | $3,384 | $383,152 | 2 | Manga Entertainment | false | false |
| 18 | 12 | Manual of Love 2 | $135,026 | -51.2% | 149 | -17 | $906 | $1,026,988 | 3 | DeAPlaneta | false | false |
| 19 | - | Breaking and Entering | $102,929 | - | 34 | - | $3,027 | $102,929 | 1 | Buena Vista International | true | false |
| 20 | 18 | Little Miss Sunshine | $101,278 | -3.6% | 43 | +3 | $2,355 | $3,774,002 | 20 | 20th Century Fox International | false | false |
