| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Ghost Rider | $1,538,075 | -50.7% | 417 | +2 | $3,688 | $5,283,244 | 2 | Sony Pictures Releasing | false | false |
| 2 | 2 | Blood Diamond | $1,175,598 | -16.7% | 345 | -3 | $3,407 | $5,997,950 | 3 | Warner Bros. | false | false |
| 3 | - | The Grudge 2 | $1,108,248 | - | 284 | - | $3,902 | $1,108,248 | 1 | - | true | false |
| 4 | - | Bordertown | $951,165 | - | 270 | - | $3,522 | $951,165 | 1 | TriPictures | true | false |
| 5 | 3 | Night at the Museum | $836,674 | -25.5% | 374 | -53 | $2,237 | $15,634,758 | 5 | 20th Century Fox International | false | false |
| 6 | 4 | The Pursuit of Happyness | $820,835 | -21.8% | 289 | -1 | $2,840 | $7,115,787 | 4 | Sony Pictures Releasing | false | false |
| 7 | - | The Last King of Scotland | $446,153 | - | 90 | - | $4,957 | $446,153 | 1 | 20th Century Fox International | true | false |
| 8 | 6 | Babel | $398,616 | -10.8% | 211 | -1 | $1,889 | $12,722,590 | 9 | United International Pictures | false | false |
| 9 | 5 | John Tucker Must Die | $388,711 | -34% | 250 | - | $1,554 | $2,158,237 | 3 | 20th Century Fox International | false | false |
| 10 | 9 | The Lives of Others | $370,546 | +31% | 75 | -2 | $4,940 | $784,366 | 2 | Alta Films | false | false |
| 11 | 8 | Letters from Iwo Jima | $315,933 | -14.4% | 69 | +1 | $4,578 | $839,263 | 2 | Warner Bros. | false | false |
| 12 | 7 | Manual of Love 2 | $276,924 | -32.2% | 166 | +1 | $1,668 | $812,789 | 2 | DeAPlaneta | false | false |
| 13 | 14 | Pan's Labyrinth | $199,527 | +29.4% | 99 | +7 | $2,015 | $10,876,001 | 20 | Warner Bros. | false | false |
| 14 | - | Paris, Je T'aime | $171,442 | - | 40 | - | $4,286 | $171,837 | 1 | Manga Entertainment | true | false |
| 15 | 10 | Little Children | $156,079 | -29.5% | 105 | -5 | $1,486 | $878,918 | 3 | TriPictures | false | false |
| 16 | - | The Night Listener | $133,147 | - | 132 | - | $1,008 | $133,147 | 1 | Eurocine | true | false |
| 17 | 11 | Apocalypto | $116,716 | -45.1% | 145 | -70 | $804 | $5,856,675 | 6 | - | false | false |
| 18 | 18 | Little Miss Sunshine | $105,061 | +41.6% | 40 | +2 | $2,626 | $3,643,974 | 19 | 20th Century Fox International | false | false |
| 19 | 12 | Miss Potter | $102,998 | -51% | 143 | -42 | $720 | $876,668 | 3 | - | false | false |
