| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Blood Diamond | $2,326,037 | - | 351 | - | $6,626 | $2,326,037 | 1 | Warner Bros. | true | false |
| 2 | 1 | Night at the Museum | $2,068,397 | -45.1% | 468 | -14 | $4,419 | $12,755,268 | 3 | 20th Century Fox International | false | false |
| 3 | 2 | The Pursuit of Happyness | $1,571,405 | -35.8% | 290 | +5 | $5,418 | $4,542,354 | 2 | Sony Pictures Releasing | false | false |
| 4 | - | John Tucker Must Die | $900,355 | - | 249 | - | $3,615 | $900,355 | 1 | 20th Century Fox International | true | false |
| 5 | 4 | Babel | $584,923 | -32.1% | 212 | -2 | $2,759 | $11,420,763 | 7 | United International Pictures | false | false |
| 6 | 3 | Pulse | $452,537 | -48.5% | 251 | -1 | $1,802 | $1,461,135 | 2 | DeAPlaneta | false | false |
| 7 | - | Días de cine | $393,598 | - | 248 | - | $1,587 | $393,598 | 1 | Buena Vista International | true | false |
| 8 | 5 | Apocalypto | $382,319 | -46.6% | 267 | -12 | $1,431 | $5,254,340 | 4 | Aurum Films | false | false |
| 9 | - | Miss Potter | $347,122 | - | 184 | - | $1,886 | $347,122 | 1 | Aurum Films | true | false |
| 10 | - | Little Children | $314,851 | - | 110 | - | $2,862 | $314,851 | 1 | TriPictures | true | false |
| 11 | 8 | Black Book | $219,557 | -31.5% | 81 | -1 | $2,710 | $655,113 | 2 | Manga Entertainment | false | false |
| 12 | 13 | Pan's Labyrinth | $186,807 | +5.1% | 95 | +13 | $1,966 | $10,242,250 | 18 | Warner Bros. | false | false |
| 13 | 6 | Smokin' Aces | $169,927 | -62.2% | 173 | -2 | $982 | $737,831 | 2 | Universal Pictures International (UPI) | false | false |
| 14 | 10 | Dreamgirls | $152,330 | -26.5% | 157 | -113 | $970 | $1,384,079 | 3 | Universal Pictures International (UPI) | false | false |
| 15 | 7 | The Prestige | $146,391 | -62.1% | 147 | -122 | $995 | $4,846,319 | 5 | Warner Bros. | false | false |
| 16 | 15 | Shin Chan: The Adult Empire Strikes Back 2006 Re-release | $118,131 | -27.3% | 155 | -12 | $762 | $297,518 | 2 | Luk Internacional S.A. | false | false |
| 17 | - | The Science of Sleep | $100,816 | - | 45 | - | $2,240 | $100,816 | 1 | Vértigo Films | true | false |
| 18 | 16 | The Illusionist | $99,357 | -37.4% | 82 | -28 | $1,211 | $12,775,508 | 13 | Aurum Films | false | false |
| 19 | - | Little Miss Sunshine | $90,698 | - | 39 | - | $2,325 | $3,552,052 | 17 | 20th Century Fox International | false | false |
