| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Manual of Love 2 | $5,349,872 | -33.3% | 588 | -2 | $9,098 | $16,784,753 | 2 | Filmauro | false | false |
| 2 | 2 | The Pursuit of Happyness | $2,640,592 | -33.4% | 420 | -21 | $6,287 | $15,117,360 | 3 | Medusa Distribuzione | false | false |
| 3 | - | Step Up | $1,568,397 | - | 236 | - | $6,645 | $1,568,397 | 1 | Medusa Distribuzione | true | false |
| 4 | - | Blood Diamond | $1,556,338 | - | 264 | - | $5,895 | $1,556,338 | 1 | Warner Bros. | true | false |
| 5 | 3 | Rocky Balboa | $674,517 | -57.5% | 253 | -71 | $2,666 | $7,855,966 | 3 | 20th Century Fox International | false | false |
| 6 | 4 | Casino Royale | $470,496 | -54.8% | 166 | -114 | $2,834 | $9,793,039 | 4 | Sony Pictures Releasing | false | false |
| 7 | 7 | Bobby | $371,160 | -23.5% | 141 | -6 | $2,632 | $1,047,508 | 2 | 01 Distribution | false | false |
| 8 | - | Dreamgirls | $359,008 | - | 172 | - | $2,087 | $359,008 | 1 | Universal Pictures International (UPI) | true | false |
| 9 | 5 | Apocalypto | $291,556 | -63.6% | 128 | -115 | $2,277 | $8,278,790 | 4 | Eagle Pictures | false | false |
| 10 | 6 | The Guardian | $220,681 | -60% | 168 | -31 | $1,313 | $993,216 | 2 | Eagle Pictures | false | false |
| 11 | 8 | Flushed Away | $152,976 | -47.7% | 125 | -46 | $1,223 | $8,251,497 | 6 | United International Pictures | false | false |
| 12 | 9 | The Science of Sleep | $131,191 | -22.5% | 48 | -2 | $2,733 | $412,667 | 2 | Mikado Film | false | false |
| 13 | 11 | The Boss of It All | $100,889 | -38% | 36 | -15 | $2,802 | $1,039,652 | 4 | Lucky Red | false | false |
| 14 | 17 | Little Red Flowers | $58,583 | +13.1% | 22 | +6 | $2,662 | $194,635 | 3 | Istituto Luce | false | false |
| 15 | 14 | The Prestige | $57,348 | -62.3% | 28 | -34 | $2,048 | $5,114,995 | 6 | Warner Bros. | false | false |
| 16 | 15 | Lights in the Dusk | $47,176 | -28.1% | 18 | -9 | $2,620 | $272,785 | 3 | BIM Distribuzione | false | false |
| 17 | 10 | A Good Year | $41,931 | -74.3% | 30 | -62 | $1,397 | $6,963,579 | 7 | Medusa Distribuzione | false | false |
| 18 | 19 | After the Wedding | $41,765 | +5.6% | 22 | +1 | $1,898 | $556,947 | 6 | Teodora Film | false | false |
| 19 | 16 | Salty Air | $40,701 | -25.7% | 27 | -9 | $1,507 | $521,556 | 4 | 01 Distribution | false | false |
| 20 | - | La strada di Levi | $36,883 | - | 18 | - | $2,049 | $106,127 | 2 | 01 Distribution | false | false |
