| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Epic Movie | $2,139,740 | - | 207 | - | $10,336 | $2,153,651 | 1 | 20th Century Fox International | true | false |
| 2 | 1 | Deja Vu | $1,410,078 | -26.3% | 300 | +8 | $4,700 | $4,196,021 | 2 | Buena Vista International | false | false |
| 3 | 2 | The Pursuit of Happyness | $1,315,906 | -22.6% | 222 | - | $5,927 | $7,767,785 | 3 | Sony Pictures Releasing | false | false |
| 4 | - | Miss Potter | $1,119,215 | - | 240 | - | $4,663 | $1,119,215 | 1 | Icon Film Distribution | true | false |
| 5 | 3 | Happy Feet | $881,604 | -33.1% | 306 | -49 | $2,881 | $23,156,937 | 5 | Roadshow Films | false | false |
| 6 | 4 | Night at the Museum | $860,954 | -33.3% | 279 | -26 | $3,085 | $17,364,196 | 5 | 20th Century Fox International | false | false |
| 7 | 5 | Dreamgirls | $651,704 | -33.1% | 139 | - | $4,688 | $2,090,036 | 2 | Paramount Pictures International | false | false |
| 8 | 7 | The Queen | $551,027 | -9.2% | 129 | +45 | $4,271 | $4,856,679 | 5 | Icon Film Distribution | false | false |
| 9 | 6 | Casino Royale | $486,716 | -25.6% | 201 | -79 | $2,421 | $23,571,199 | 8 | Sony Pictures Releasing | false | false |
| 10 | 8 | Blood Diamond | $472,030 | -15.1% | 170 | -16 | $2,776 | $4,712,013 | 4 | Warner Bros. | false | false |
| 11 | 12 | Babel | $410,590 | -1.3% | 66 | +2 | $6,221 | $3,625,876 | 5 | United International Pictures | false | false |
| 12 | 9 | Flushed Away | $316,721 | -35.8% | 207 | -20 | $1,530 | $6,898,620 | 6 | United International Pictures | false | false |
| 13 | 11 | Apocalypto | $261,397 | -42.8% | 157 | +3 | $1,664 | $2,147,776 | 3 | Icon Film Distribution | false | false |
| 14 | 10 | The Holiday | $232,740 | -50.7% | 161 | -61 | $1,445 | $9,489,951 | 7 | Universal Pictures | false | false |
| 15 | 14 | Pan's Labyrinth | $193,133 | -8.3% | 22 | +3 | $8,778 | $551,206 | 3 | Hopscotch Films | false | false |
| 16 | 13 | Arthur and the Invisibles | $171,138 | -39.5% | 158 | -13 | $1,083 | $1,318,208 | 3 | Roadshow Films | false | false |
| 17 | - | Breaking and Entering | $111,897 | - | 26 | - | $4,303 | $158,947 | 1 | Buena Vista International | true | false |
| 18 | - | Salaam-e-Ishq | $89,843 | - | 13 | - | $6,911 | $124,622 | 1 | Eros Worldwide | true | false |
| 19 | 15 | Charlotte's Web | $84,727 | -50.9% | 68 | -52 | $1,245 | $6,646,468 | 8 | United International Pictures | false | false |
| 20 | - | The Fountain | $73,159 | - | 35 | - | $2,090 | $73,159 | 1 | 20th Century Fox International | true | false |
