| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 2 | The Departed | $333,847 | -41.1% | 85 | - | $3,927 | $1,896,624 | 3 | Warner Bros. | false | false |
| 2 | 4 | The Holiday | $250,888 | -43.9% | 85 | +30 | $2,951 | $2,192,814 | 4 | United International Pictures | false | false |
| 3 | 6 | John Tucker Must Die | $200,813 | -46.2% | 30 | - | $6,693 | $589,445 | 2 | 20th Century Fox International | false | false |
| 4 | 1 | Happy Feet | $198,950 | -72% | 121 | - | $1,644 | $3,909,589 | 6 | Warner Bros. | false | false |
| 5 | - | The Prestige | $187,434 | - | 30 | - | $6,247 | $208,003 | 1 | Warner Bros. | true | false |
| 6 | 3 | Eragon | $185,512 | -65.4% | 90 | - | $2,061 | $2,483,506 | 4 | 20th Century Fox International | false | false |
| 7 | 7 | Casino Royale | $166,564 | -54.7% | 80 | - | $2,082 | $5,563,272 | 8 | Sony Pictures Releasing | false | false |
| 8 | 10 | Deja Vu | $140,048 | -45.1% | 49 | - | $2,858 | $1,756,128 | 5 | Buena Vista International | false | false |
| 9 | 5 | Arthur and the Invisibles | $137,722 | -65.3% | 64 | - | $2,151 | $2,008,481 | 5 | United International Pictures | false | false |
| 10 | 11 | Saw III | $104,693 | -55% | 39 | - | $2,684 | $1,430,001 | 4 | Les Films de l'Elysée | false | false |
| 11 | 13 | Babel | $82,519 | -23.5% | 29 | - | $2,845 | $1,812,665 | 9 | Belga Films | false | false |
| 12 | 9 | Flushed Away | $65,613 | -74.5% | 74 | - | $886 | $1,894,922 | 7 | United International Pictures | false | false |
| 13 | 8 | Plop in de stad | $65,149 | -75.4% | 32 | - | $2,035 | $917,695 | 5 | Belga Films | false | false |
| 14 | 14 | My Best Friend | $49,002 | -47.9% | 24 | - | $2,041 | $333,437 | 3 | N/A | false | false |
| 15 | 15 | Priceless | $43,784 | -35.7% | 11 | - | $3,980 | $442,592 | 5 | Paradiso Entertainment | false | false |
| 16 | 12 | Franklin and the Turtle Lake Treasure | $31,592 | -72.7% | 19 | - | $1,662 | $374,404 | 4 | Cinéart | false | false |
| 17 | 18 | Borat | $23,261 | -54% | 27 | - | $861 | $2,863,302 | 11 | 20th Century Fox International | false | false |
| 18 | - | Little Miss Sunshine | $21,726 | - | 4 | - | $5,431 | $331,010 | 7 | 20th Century Fox International | false | false |
| 19 | - | Fur: An Imaginary Portrait of Diane Arbus | $21,173 | - | 3 | - | $7,057 | $21,459 | 1 | Paradise Group | true | false |
| 20 | 17 | Step Up | $20,880 | -61.1% | 20 | - | $1,044 | $2,051,846 | 11 | Belga Films | false | false |
