| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Night at the Museum | $4,992,215 | -50.7% | 749 | -35 | $6,665 | $13,952,060 | 2 | 20th Century Fox International | false | false |
| 2 | 2 | Deja Vu | $2,349,057 | -30% | 601 | - | $3,908 | $7,108,988 | 2 | Buena Vista International | false | false |
| 3 | 3 | Casino Royale | $2,240,272 | -11.4% | 524 | -104 | $4,275 | $46,129,570 | 7 | Sony Pictures Releasing | false | false |
| 4 | 4 | The Holiday | $2,014,900 | -0.6% | 544 | -1 | $3,703 | $11,959,692 | 4 | United International Pictures | false | false |
| 5 | 5 | Eragon | $1,312,022 | -24.6% | 763 | -25 | $1,719 | $12,274,359 | 4 | 20th Century Fox International | false | false |
| 6 | - | Charlotte's Web | $1,038,997 | - | 401 | - | $2,591 | $1,038,997 | 1 | United International Pictures | true | false |
| 7 | 6 | The Departed | $868,306 | +0.4% | 384 | -34 | $2,261 | $8,776,637 | 5 | Warner Bros. | false | false |
| 8 | 8 | Babel | $759,337 | +22.1% | 114 | +7 | $6,660 | $2,554,219 | 3 | TOBIS Film | false | false |
| 9 | - | The Prestige | $659,895 | - | 124 | - | $5,321 | $659,895 | 1 | Warner Bros. | true | false |
| 10 | 7 | Happy Feet | $605,094 | -11.8% | 635 | -59 | $952 | $7,373,918 | 6 | Warner Bros. | false | false |
| 11 | 9 | Flushed Away | $498,510 | -7.1% | 588 | -35 | $847 | $4,714,597 | 5 | United International Pictures | false | false |
| 12 | 11 | Vitus | $251,969 | +14.9% | 70 | -1 | $3,599 | $896,398 | 3 | S&W Entertainment Limited | false | false |
| 13 | 12 | Grave Decisions | $244,055 | +37.8% | 90 | +30 | $2,711 | $10,219,986 | 21 | Movienet | false | false |
| 14 | - | Gridiron Gang | $221,051 | - | 99 | - | $2,232 | $221,051 | 1 | Sony Pictures Releasing | true | false |
| 15 | 15 | Little Miss Sunshine | $187,230 | +23.6% | 110 | +55 | $1,702 | $1,868,407 | 6 | 20th Century Fox International | false | false |
