| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Casino Royale | $2,896,961 | -46.2% | 401 | - | $7,224 | $10,339,434 | 2 | Sony Pictures Releasing | false | false |
| 2 | - | Eragon | $1,664,465 | - | 321 | - | $5,185 | $1,664,465 | 1 | 20th Century Fox International | true | false |
| 3 | 3 | Charlotte's Web | $935,363 | -3.7% | 346 | - | $2,703 | $2,490,465 | 2 | United International Pictures | false | false |
| 4 | 2 | Borat | $709,877 | -35.6% | 268 | -11 | $2,648 | $11,815,243 | 4 | 20th Century Fox International | false | false |
| 5 | 4 | Open Season | $644,175 | -6.9% | 231 | - | $2,788 | $3,073,619 | 3 | Sony Pictures Releasing | false | false |
| 6 | 5 | The Santa Clause 3: The Escape Clause | $405,886 | +8.7% | 213 | +1 | $1,905 | $3,721,413 | 5 | Buena Vista International | false | false |
| 7 | - | The Holiday | $378,888 | - | 178 | - | $2,128 | $378,888 | 1 | Universal Pictures | true | false |
| 8 | 6 | The Prestige | $154,062 | -44.2% | 135 | -48 | $1,141 | $4,143,812 | 5 | Warner Bros. | false | false |
| 9 | 7 | The Guardian | $138,766 | -44.2% | 190 | -17 | $730 | $1,349,480 | 3 | Buena Vista International | false | false |
| 10 | - | Babel | $106,046 | - | 40 | - | $2,651 | $106,046 | - | United International Pictures | - | false |
| 11 | - | Volver | $64,010 | - | 23 | - | $2,783 | $64,010 | 1 | Icon Film Distribution | true | false |
| 12 | 8 | Little Miss Sunshine | $56,804 | -33.5% | 69 | -15 | $823 | $4,741,739 | 11 | Park Circus | false | false |
| 13 | 9 | Unaccompanied Minors | $56,742 | -33.5% | 70 | -34 | $810 | $415,025 | 3 | Roadshow Films | false | false |
| 14 | - | The Valet | $36,857 | - | 15 | - | $2,457 | $36,857 | - | Sharmill Films | - | false |
| 15 | 10 | Jackass Number Two | $36,502 | -47.1% | 40 | -39 | $912 | $4,416,759 | 6 | United International Pictures | false | false |
| 16 | 12 | The Departed | $35,063 | -35.4% | 44 | -7 | $796 | $8,884,138 | 10 | Warner Bros. | false | false |
| 17 | 13 | Deck the Halls | $26,005 | -48.5% | 69 | -67 | $376 | $570,924 | 4 | 20th Century Fox International | false | false |
| 18 | 14 | The Nativity Story | $25,660 | -45.5% | 51 | -57 | $503 | $249,109 | 3 | Roadshow Films | false | false |
| 19 | 18 | Baabul | $24,397 | -26.9% | 8 | +1 | $3,049 | $70,464 | 2 | Saini Enterprises | false | false |
| 20 | 15 | Saw III | $22,942 | -39.7% | 20 | -16 | $1,147 | $5,173,137 | 7 | Hoyts Distribution | false | false |
| 21 | - | Kabul Express | $21,420 | - | 1 | - | $21,420 | $21,420 | 1 | MG Distribution | true | false |
