| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Happy Feet | $7,209,627 | - | 445 | - | $16,201 | $7,209,627 | 1 | Warner Bros. | true | false |
| 2 | - | The Holiday | $5,523,783 | - | 428 | - | $12,906 | $5,523,783 | 1 | United International Pictures | true | false |
| 3 | 1 | Casino Royale | $5,357,362 | -49% | 495 | -65 | $10,822 | $82,001,460 | 4 | Sony Pictures Releasing | false | false |
| 4 | 2 | Flushed Away | $2,386,615 | -61.2% | 470 | +2 | $5,077 | $9,329,955 | 2 | United International Pictures | false | false |
| 5 | 3 | The Santa Clause 3: The Escape Clause | $1,434,514 | -27.7% | 389 | +9 | $3,687 | $7,148,505 | 3 | Buena Vista International | false | false |
| 6 | 5 | Deck the Halls | $723,326 | -39.1% | 307 | - | $2,356 | $2,309,807 | 2 | 20th Century Fox International | false | false |
| 7 | 4 | Borat | $657,319 | -57.3% | 297 | -91 | $2,213 | $45,664,487 | 6 | 20th Century Fox International | false | false |
| 8 | - | Baabul | $566,531 | - | 45 | - | $12,589 | $566,531 | 1 | Adlabs Films | true | false |
| 9 | - | The Covenant | $354,436 | - | 158 | - | $2,243 | $354,436 | 1 | Sony Pictures Releasing | true | false |
| 10 | 9 | Pan's Labyrinth | $348,218 | -28.6% | 88 | +7 | $3,957 | $2,158,140 | 3 | Optimum Releasing | false | false |
| 11 | 7 | Stranger Than Fiction | $258,640 | -64.6% | 146 | -40 | $1,771 | $1,373,772 | 2 | Sony Pictures Releasing | false | false |
| 12 | 6 | Tenacious D in the Pick of Destiny | $196,111 | -74.3% | 158 | -152 | $1,241 | $3,828,689 | 3 | Entertainment Film Distributors | false | false |
| 13 | - | The Nativity Story | $153,514 | - | 252 | - | $609 | $153,514 | 1 | Entertainment Film Distributors | true | false |
| 14 | 10 | Dhoom 2 | $153,225 | -67.2% | 48 | -2 | $3,192 | $2,030,922 | 3 | Yash Raj Films | false | false |
| 15 | 8 | Jackass Number Two | $142,245 | -77.5% | 147 | -198 | $967 | $3,292,306 | 3 | United International Pictures | false | false |
| 16 | 11 | The Prestige | $81,730 | -70.5% | 70 | -75 | $1,167 | $6,603,973 | 5 | Warner Bros. | false | false |
| 17 | 13 | The Nightmare Before Christmas 2006 3D Release | $78,935 | -39.3% | 5 | - | $15,787 | $373,125 | 4 | Buena Vista International | false | false |
| 18 | 18 | London to Brighton | $54,090 | -6.3% | 19 | +4 | $2,846 | $152,652 | 2 | Vertigo Films | false | false |
| 19 | 16 | Shortbus | $52,929 | -26.6% | 16 | -2 | $3,308 | $181,739 | 2 | The Works UK Distribution | false | false |
| 20 | 14 | Breaking and Entering | $34,192 | -64.4% | 41 | -6 | $833 | $1,859,867 | 5 | Buena Vista International | false | false |
| 21 | - | The U.S. vs. John Lennon | $27,344 | - | 21 | - | $1,302 | $27,344 | 1 | Lionsgate | true | false |
| 22 | 19 | The Departed | $23,316 | -56.1% | 18 | -14 | $1,295 | $24,760,557 | 10 | Entertainment Film Distributors | false | false |
| 23 | 12 | Big Nothing | $21,958 | -86.8% | 35 | -66 | $627 | $288,857 | 2 | Pathé | false | false |
| 24 | 21 | The History Boys | $21,206 | -22.6% | 14 | -11 | $1,514 | $7,614,862 | 9 | 20th Century Fox International | false | false |
| 25 | 25 | The Page Turner | $16,217 | -28.1% | 10 | -2 | $1,621 | $547,440 | 6 | Artificial Eye | false | false |
| 26 | 24 | The Devil Wears Prada | $13,236 | -41.7% | 11 | -12 | $1,203 | $27,091,767 | 10 | 20th Century Fox International | false | false |
| 27 | 17 | Saw III | $12,163 | -81.3% | 20 | -52 | $608 | $16,714,172 | 7 | Lionsgate | false | false |
| 28 | 22 | The Queen | $11,927 | -53.7% | 5 | -9 | $2,385 | $14,885,546 | 13 | Pathé | false | false |
| 29 | 29 | Gabrielle | $11,812 | -17.5% | 5 | +1 | $2,362 | $114,620 | 4 | Artificial Eye | false | false |
| 30 | 41 | Hoodwinked! | $10,920 | +233.7% | 75 | +53 | $145 | $11,294,133 | 11 | Momentum Pictures | false | false |
| 31 | - | Ice Cream, I Scream | $10,096 | - | 2 | - | $5,048 | $10,096 | 1 | Maxximum Film und Kunst GmbH | true | false |
| 32 | 26 | Barnyard | $7,864 | -61.6% | 42 | -50 | $187 | $8,809,154 | 8 | United International Pictures | false | false |
| 33 | 37 | Children of Men | $7,457 | +17.8% | 3 | +1 | $2,485 | $9,448,966 | 12 | United International Pictures | false | false |
| 34 | 33 | The Dead | $7,348 | -0.9% | 1 | - | $7,348 | $22,707 | 2 | Park Circus | false | false |
| 35 | 15 | Step Up | $7,215 | -90.7% | 28 | -64 | $257 | $8,599,685 | 7 | United International Pictures | false | false |
| 36 | 28 | Open Season | $7,059 | -53.2% | 32 | -39 | $220 | $14,540,035 | 9 | Sony Pictures Releasing | false | false |
| 37 | - | Manhattan 2006 Re-release | $6,957 | - | 2 | - | $3,478 | $6,957 | 1 | Park Circus | true | false |
| 38 | - | Red Road | $6,940 | - | 7 | - | $991 | $602,183 | 7 | Verve Pictures | false | false |
| 39 | - | Veyil | $6,322 | - | 2 | - | $3,161 | $6,322 | 1 | Ayngaran International | true | false |
| 40 | 20 | Starter for 10 | $5,255 | -81.4% | 8 | -14 | $656 | $1,140,944 | 5 | Icon Film Distribution | false | false |
| 41 | 36 | Marie Antoinette | $5,247 | -20% | 3 | -6 | $1,749 | $1,790,424 | 8 | Sony Pictures Releasing | false | false |
| 42 | 23 | Vivah | $5,169 | -78.2% | 7 | -6 | $738 | $502,505 | 5 | Adlabs Films | false | false |
| 43 | 38 | Volver | $5,142 | +8.5% | 4 | +2 | $1,285 | $5,360,205 | 16 | Pathé | false | false |
| 44 | - | Pandora's Box | $3,987 | - | 1 | - | $3,987 | $3,987 | 1 | British Film Institute (BFI) | true | false |
| 45 | 30 | Sixty Six | $3,856 | -68.2% | 4 | -7 | $964 | $1,655,560 | 6 | United International Pictures | false | false |
| 46 | 39 | An Inconvenient Truth | $2,996 | -25.5% | 6 | -1 | $499 | $1,556,981 | 13 | United International Pictures | false | false |
| 47 | 34 | A Good Year | $2,425 | -66.5% | 5 | -4 | $485 | $1,834,813 | 7 | 20th Century Fox International | false | false |
| 48 | 48 | Zidane - A 21st Century Portrait | $2,263 | +169.4% | 4 | +3 | $565 | $294,747 | 11 | Artificial Eye | false | false |
| 49 | 42 | Romanzo Criminale | $2,109 | -30.6% | 3 | -1 | $703 | $188,681 | 6 | Icon Film Distribution | false | false |
| 50 | 44 | The Host | $2,070 | -20.2% | 7 | +2 | $295 | $246,269 | 5 | Optimum Releasing | false | false |
