| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Casino Royale | $10,512,911 | -36.3% | 560 | +54 | $18,773 | $70,679,788 | 3 | Sony Pictures Releasing | false | false |
| 2 | - | Flushed Away | $6,153,444 | - | 468 | - | $13,148 | $6,153,444 | 1 | United International Pictures | true | false |
| 3 | 3 | The Santa Clause 3: The Escape Clause | $1,983,652 | -19.4% | 380 | +5 | $5,220 | $5,296,982 | 2 | Buena Vista International | false | false |
| 4 | 2 | Borat | $1,538,546 | -45.8% | 388 | -53 | $3,965 | $44,957,887 | 5 | 20th Century Fox International | false | false |
| 5 | - | Deck the Halls | $1,188,447 | - | 307 | - | $3,871 | $1,188,447 | 1 | 20th Century Fox International | true | false |
| 6 | 4 | Tenacious D in the Pick of Destiny | $763,220 | -57.2% | 310 | -6 | $2,462 | $3,329,235 | 2 | Entertainment Film Distributors | false | false |
| 7 | - | Stranger Than Fiction | $730,099 | - | 186 | - | $3,925 | $730,099 | 1 | Sony Pictures Releasing | true | false |
| 8 | 5 | Jackass Number Two | $631,779 | -55.5% | 345 | -13 | $1,831 | $2,891,973 | 2 | United International Pictures | false | false |
| 9 | 8 | Pan's Labyrinth | $487,903 | -15.4% | 81 | +6 | $6,023 | $1,514,078 | 2 | Optimum Releasing | false | false |
| 10 | 6 | Dhoom 2 | $467,332 | -41.8% | 50 | -1 | $9,346 | $1,746,726 | 2 | Yash Raj Films | false | false |
| 11 | 7 | The Prestige | $276,841 | -56.3% | 145 | -65 | $1,909 | $6,466,500 | 4 | Warner Bros. | false | false |
| 12 | - | Big Nothing | $166,031 | - | 101 | - | $1,643 | $166,031 | 1 | Pathé | true | false |
| 13 | 22 | The Nightmare Before Christmas 2006 3D Release | $130,061 | +329.2% | 5 | +4 | $26,012 | $228,192 | 3 | Buena Vista International | false | false |
| 14 | 16 | Breaking and Entering | $96,090 | +24.3% | 47 | +7 | $2,044 | $1,796,031 | 4 | Buena Vista International | false | false |
| 15 | 9 | Step Up | $77,827 | -75.7% | 92 | -153 | $845 | $8,686,417 | 6 | United International Pictures | false | false |
| 16 | - | Shortbus | $72,141 | - | 18 | - | $4,007 | $72,141 | 1 | The Works UK Distribution | true | false |
| 17 | 10 | Saw III | $65,082 | -69.2% | 72 | -98 | $903 | $16,910,257 | 6 | Lionsgate | false | false |
| 18 | - | London to Brighton | $57,740 | - | 15 | - | $3,849 | $57,740 | 1 | Vertigo Films | true | false |
| 19 | 14 | The Departed | $53,167 | -45.3% | 32 | -24 | $1,661 | $25,035,960 | 9 | Entertainment Film Distributors | false | false |
| 20 | 15 | Starter for 10 | $28,223 | -63.8% | 22 | -34 | $1,282 | $1,131,800 | 4 | Icon Film Distribution | false | false |
| 21 | 20 | The History Boys | $27,407 | -22.8% | 25 | -2 | $1,096 | $7,839,453 | 8 | 20th Century Fox International | false | false |
| 22 | 24 | The Queen | $25,762 | -6.8% | 14 | +3 | $1,840 | $15,021,842 | 12 | Pathé | false | false |
| 23 | 18 | Vivah | $23,729 | -52.1% | 13 | -8 | $1,825 | $490,683 | 4 | Adlabs Films | false | false |
| 24 | 17 | The Devil Wears Prada | $22,705 | -63.4% | 23 | -46 | $987 | $27,415,843 | 9 | 20th Century Fox International | false | false |
| 25 | 19 | The Page Turner | $22,555 | -48.8% | 12 | -2 | $1,879 | $522,452 | 5 | Artificial Eye | false | false |
| 26 | 11 | Barnyard | $20,505 | -87.4% | 92 | -179 | $222 | $8,918,144 | 7 | United International Pictures | false | false |
| 27 | 12 | Hollywoodland | $16,890 | -86.7% | 26 | -81 | $649 | $244,583 | 2 | Buena Vista International | false | false |
| 28 | 13 | Open Season | $15,084 | -86.1% | 71 | -199 | $212 | $14,726,263 | 8 | Sony Pictures Releasing | false | false |
| 29 | 27 | Gabrielle | $14,318 | -37.7% | 4 | +2 | $3,579 | $98,041 | 3 | Artificial Eye | false | false |
| 30 | 23 | Sixty Six | $12,129 | -56.2% | 11 | +7 | $1,102 | $1,666,671 | 5 | United International Pictures | false | false |
| 31 | - | Ek Jind Ek Jaan | $10,844 | - | 8 | - | $1,355 | $10,844 | 1 | N/A | true | false |
| 32 | 26 | Little Miss Sunshine | $8,835 | -62.2% | 11 | -1 | $803 | $6,379,287 | 13 | 20th Century Fox International | false | false |
| 33 | - | The Dead | $7,417 | - | 1 | - | $7,417 | $7,417 | 1 | Park Circus | true | false |
| 34 | 33 | A Good Year | $7,249 | -39.1% | 9 | -6 | $805 | $1,844,363 | 6 | 20th Century Fox International | false | false |
| 35 | 28 | Umrao Jaan | $7,223 | -62.5% | 7 | +3 | $1,031 | $813,288 | 5 | Adlabs Films | false | false |
| 36 | 29 | Marie Antoinette | $6,560 | -62.9% | 9 | +3 | $728 | $1,800,404 | 7 | Sony Pictures Releasing | false | false |
| 37 | 32 | Children of Men | $6,330 | -50.2% | 2 | -8 | $3,165 | $9,562,658 | 11 | United International Pictures | false | false |
| 38 | 45 | Volver | $4,738 | -5.1% | 2 | - | $2,369 | $5,421,856 | 15 | Pathé | false | false |
| 39 | 41 | An Inconvenient Truth | $4,019 | -44.9% | 7 | -3 | $574 | $1,565,106 | 12 | United International Pictures | false | false |
| 40 | 37 | Leonard Cohen: I'm Your Man | $3,716 | -57.4% | 2 | -2 | $1,858 | $60,327 | 7 | Lionsgate | false | false |
| 41 | 25 | Hoodwinked! | $3,272 | -88% | 22 | +13 | $148 | $11,434,720 | 10 | Momentum Pictures | false | false |
| 42 | 38 | Romanzo Criminale | $3,038 | -63.5% | 4 | -3 | $759 | $186,403 | 5 | Icon Film Distribution | false | false |
| 43 | 34 | Rendu | $2,636 | -73.6% | 2 | - | $1,318 | $18,241 | 2 | Ayngaran International | false | false |
| 44 | 39 | The Host | $2,595 | -67.7% | 5 | -3 | $519 | $244,641 | 4 | Optimum Releasing | false | false |
| 45 | 21 | Over the Hedge | $1,305 | -95.9% | 4 | -85 | $326 | $25,901,994 | 23 | United International Pictures | false | false |
| 46 | 49 | Exam | $1,216 | -64.2% | 1 | - | $1,216 | $59,303 | 6 | Maxximum Film und Kunst GmbH | false | false |
| 47 | 46 | Mischief Night | $992 | -78.7% | 1 | -4 | $992 | $276,714 | 5 | Verve Pictures | false | false |
| 48 | - | Zidane - A 21st Century Portrait | $840 | - | 1 | - | $840 | $295,167 | 10 | Artificial Eye | false | false |
| 49 | 36 | Something New | $749 | -91.8% | 1 | -14 | $749 | $15,101 | 2 | United International Pictures | false | false |
| 50 | - | I Saw Ben Barka Get Killed | $727 | - | 2 | - | $363 | $48,726 | 7 | Artificial Eye | false | false |
