| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Saw III | $2,884,987 | - | 300 | - | $9,616 | $2,987,760 | 1 | Buena Vista International | true | false |
| 2 | - | Open Season | $1,672,616 | - | 400 | - | $4,181 | $1,672,616 | 1 | Sony Pictures Releasing | true | false |
| 3 | 1 | The Departed | $1,352,761 | -27.8% | 367 | -2 | $3,685 | $7,784,349 | 3 | Warner Bros. | false | false |
| 4 | 2 | A Good Year | $963,016 | -23.3% | 300 | +1 | $3,210 | $2,581,368 | 2 | 20th Century Fox International | false | false |
| 5 | 3 | Scoop | $839,599 | -19.7% | 161 | +2 | $5,214 | $4,345,568 | 3 | On Pictures | false | false |
| 6 | - | Goya's Ghosts | $827,715 | - | 362 | - | $2,286 | $906,659 | 1 | Warner Bros. | true | false |
| 7 | - | The Queen | $543,558 | - | 185 | - | $2,938 | $585,503 | 1 | Vértigo Films | true | false |
| 8 | 5 | Nobody Is Perfect | $456,332 | -39.8% | 192 | -9 | $2,376 | $2,807,061 | 3 | Sony Pictures Releasing | false | false |
| 9 | 4 | GAL | $444,577 | -48.7% | 335 | -15 | $1,327 | $1,589,582 | 2 | 20th Century Fox International | false | false |
| 10 | 6 | Pan's Labyrinth | $429,636 | -42.4% | 250 | -49 | $1,718 | $8,385,174 | 5 | Warner Bros. | false | false |
| 11 | 7 | The Texas Chainsaw Massacre: The Beginning | $251,718 | -64.8% | 161 | +1 | $1,563 | $1,105,108 | 2 | TriPictures | false | false |
| 12 | 13 | Little Miss Sunshine | $213,349 | -34.1% | 109 | -47 | $1,957 | $1,855,064 | 4 | 20th Century Fox International | false | false |
| 13 | 9 | The Borgia | $210,008 | -50.4% | 157 | -89 | $1,337 | $8,129,484 | 6 | DeAPlaneta | false | false |
| 14 | 10 | My Name Is Juani | $201,417 | -52.4% | 150 | -32 | $1,342 | $2,844,878 | 4 | Manga Entertainment | false | false |
| 15 | 11 | The Black Dahlia | $185,463 | -55.4% | 131 | -99 | $1,415 | $3,439,246 | 4 | TriPictures | false | false |
| 16 | 8 | Barnyard | $183,224 | -72% | 232 | -6 | $789 | $2,034,051 | 3 | United International Pictures | false | false |
| 17 | 12 | The Devil Wears Prada | $131,512 | -59.6% | 110 | -115 | $1,195 | $8,025,373 | 6 | 20th Century Fox International | false | false |
| 18 | 14 | Children of Men | $121,718 | -53.1% | 83 | -82 | $1,466 | $1,998,110 | 4 | United International Pictures | false | false |
| 19 | - | Fiction | $112,523 | - | 62 | - | $1,814 | $116,080 | 1 | Alta Films | true | false |
| 20 | 15 | Jackass Number Two | $96,838 | -62.4% | 99 | -1 | $978 | $399,336 | 2 | United International Pictures | false | false |
