| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Borat | $11,865,318 | - | 428 | - | $27,722 | $11,865,318 | 1 | 20th Century Fox International | true | false |
| 2 | 1 | Saw III | $2,668,042 | -44.3% | 375 | +2 | $7,114 | $10,639,010 | 2 | Lionsgate | false | false |
| 3 | 2 | Step Up | $1,323,644 | -42.5% | 310 | +3 | $4,269 | $4,716,736 | 2 | United International Pictures | false | false |
| 4 | 3 | The Departed | $1,058,398 | -46.2% | 334 | -42 | $3,168 | $21,480,975 | 5 | Entertainment Film Distributors | false | false |
| 5 | 5 | The Devil Wears Prada | $874,476 | -48.8% | 384 | -55 | $2,277 | $24,172,804 | 5 | 20th Century Fox International | false | false |
| 6 | 4 | Open Season | $765,902 | -58.4% | 440 | -8 | $1,740 | $12,534,404 | 4 | Sony Pictures Releasing | false | false |
| 7 | 6 | Barnyard | $675,940 | -52.1% | 433 | -13 | $1,561 | $6,964,621 | 3 | United International Pictures | false | false |
| 8 | - | Sixty Six | $555,588 | - | 250 | - | $2,222 | $555,588 | 1 | United International Pictures | true | false |
| 9 | 8 | The History Boys | $335,163 | -57.9% | 177 | -58 | $1,893 | $6,572,842 | 4 | 20th Century Fox International | false | false |
| 10 | - | Little Children | $300,346 | - | 203 | - | $1,479 | $300,346 | 1 | Entertainment Film Distributors | true | false |
| 11 | 7 | Click | $292,794 | -63.7% | 227 | -76 | $1,289 | $14,480,065 | 6 | Sony Pictures Releasing | false | false |
| 12 | - | Umrao Jaan | $258,527 | - | 39 | - | $6,628 | $258,527 | 1 | Adlabs Films | true | false |
| 13 | 13 | Don | $236,265 | -57.2% | 51 | -1 | $4,632 | $2,406,003 | 3 | UTV Motion Pictures | false | false |
| 14 | 10 | Hoodwinked! | $234,737 | -65.4% | 352 | -81 | $666 | $9,768,101 | 6 | Momentum Pictures | false | false |
| 15 | 9 | A Good Year | $233,326 | -67.4% | 195 | -81 | $1,196 | $1,431,479 | 2 | 20th Century Fox International | false | false |
| 16 | 12 | The Guardian | $171,781 | -73.1% | 149 | -189 | $1,152 | $3,745,060 | 3 | Buena Vista International | false | false |
| 17 | 11 | The Grudge 2 | $129,470 | -80.4% | 185 | -143 | $699 | $3,786,176 | 3 | United International Pictures | false | false |
| 18 | 15 | The Queen | $110,450 | -44.9% | 97 | -28 | $1,138 | $14,041,380 | 8 | Pathé | false | false |
| 19 | - | The Last Kiss | $103,119 | - | 79 | - | $1,305 | $2,234,338 | 3 | Momentum Pictures | false | false |
| 20 | - | Mischief Night | $97,763 | - | 98 | - | $997 | $97,763 | 1 | Verve Pictures | true | false |
| 21 | - | The Page Turner | $91,770 | - | 25 | - | $3,670 | $91,770 | 1 | Artificial Eye | true | false |
| 22 | - | Scenes of a Sexual Nature | $88,987 | - | 36 | - | $2,471 | $88,987 | 1 | Miracle Films | true | false |
| 23 | 17 | Red Road | $81,300 | -47.7% | 35 | -3 | $2,322 | $345,507 | 2 | Verve Pictures | false | false |
| 24 | 16 | Jaan-E-Mann: Lets Fall in Love Again | $80,146 | -53.2% | 27 | -8 | $2,968 | $822,385 | 3 | Adlabs Films | false | false |
| 25 | 14 | Marie Antoinette | $75,552 | -70.2% | 57 | -65 | $1,325 | $1,477,225 | 3 | Sony Pictures Releasing | false | false |
| 26 | - | Romanzo Criminale | $64,047 | - | 41 | - | $1,562 | $64,047 | 1 | Icon Film Distribution Australia | true | false |
| 27 | 19 | Little Miss Sunshine | $60,823 | -28.7% | 28 | -8 | $2,172 | $5,874,697 | 9 | 20th Century Fox International | false | false |
| 28 | 21 | Stick It | $34,391 | -56.8% | 69 | +50 | $498 | $799,707 | 4 | Buena Vista International | false | false |
| 29 | 36 | The Ant Bully | $33,648 | +570.9% | 169 | +152 | $199 | $3,794,657 | 14 | Warner Bros. | false | false |
| 30 | 23 | Children of Men | $19,622 | -72% | 17 | -357 | $1,154 | $9,074,250 | 7 | United International Pictures | false | false |
| 31 | 29 | An Inconvenient Truth | $17,379 | -0.3% | 17 | +3 | $1,022 | $9,074,250 | 8 | United International Pictures | false | false |
| 32 | 24 | The Magician | $16,805 | -51.6% | 4 | - | $4,201 | $66,883 | 2 | Diva | false | false |
| 33 | - | Deep Sea | $16,328 | - | 1 | - | $16,328 | $2,402,011 | 36 | IMAX | false | false |
| 34 | 28 | Over the Hedge | $12,764 | -44.1% | 60 | -12 | $212 | $24,790,994 | 19 | United International Pictures | false | false |
| 35 | 30 | Volver | $11,207 | -12.1% | 8 | - | $1,400 | $5,131,965 | 11 | Pathé | false | false |
| 36 | 20 | World Trade Center | $9,517 | -88.5% | 20 | -65 | $475 | $9,098,168 | 6 | United International Pictures | false | false |
| 37 | - | The Asphalt Jungle 2006 Re-release | $9,508 | - | 1 | - | $9,508 | $9,508 | 1 | British Film Institute (BFI) | true | false |
| 38 | 26 | Monster House | $9,494 | -68.2% | 34 | -29 | $279 | $12,462,338 | 13 | Sony Pictures Releasing | false | false |
| 39 | 41 | Exam | $9,473 | +231.9% | 2 | +1 | $4,736 | $24,351 | 2 | Maxximum Film und Kunst GmbH | false | false |
| 40 | - | Waist Deep | $8,991 | - | 15 | - | $599 | $8,991 | 1 | United International Pictures | true | false |
| 41 | 18 | All the King's Men | $5,221 | -94.3% | 19 | -82 | $274 | $170,969 | 2 | Sony Pictures Releasing | false | false |
| 42 | 25 | Vallavan | $4,771 | -85.9% | 3 | - | $1,590 | $49,382 | 2 | Ayngaran International | false | false |
| 43 | 33 | I Saw Ben Barka Get Killed | $2,680 | -67.1% | 2 | - | $1,340 | $36,807 | 3 | Artificial Eye | false | false |
| 44 | 39 | Leonard Cohen: I'm Your Man | $2,602 | -18.9% | 3 | +1 | $867 | $18,092 | 3 | Lionsgate | false | false |
| 45 | 31 | Accepted | $2,528 | -77.9% | 7 | -10 | $361 | $1,377,358 | 5 | United International Pictures | false | false |
| 46 | 34 | Zidane - A 21st Century Portrait | $2,490 | -64.1% | 4 | -2 | $622 | $266,898 | 6 | Artificial Eye | false | false |
| 47 | - | The Cave of the Yellow Dog | $2,469 | - | 3 | - | $823 | $258,893 | 19 | Tartan | false | false |
| 48 | - | The Wind that Shakes the Barley | $2,406 | - | 3 | - | $802 | $7,214,383 | 20 | Pathé | false | false |
| 49 | 22 | The Texas Chainsaw Massacre: The Beginning | $2,245 | -97% | 14 | -118 | $160 | $2,839,155 | 4 | Entertainment Film Distributors | false | false |
| 50 | 42 | Gypo | $1,334 | -47.1% | 3 | -1 | $444 | $22,517 | 3 | Lionsgate | false | false |
