| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Over the Hedge | $2,078,012 | - | 452 | - | $4,597 | $2,078,012 | 1 | United International Pictures | true | false |
| 2 | - | The Departed | $2,062,024 | - | 41 | - | $50,293 | $2,144,711 | 1 | Medusa Distribuzione | true | false |
| 3 | 1 | The Devil Wears Prada | $1,905,954 | -42.8% | 388 | -32 | $4,912 | $11,552,846 | 3 | 20th Century Fox International | false | false |
| 4 | 3 | The Unknown Woman | $700,925 | -25.6% | 295 | -2 | $2,376 | $2,052,379 | 2 | Medusa Distribuzione | false | false |
| 5 | 2 | World Trade Center | $688,527 | -55.7% | 250 | -83 | $2,754 | $5,500,090 | 3 | United International Pictures | false | false |
| 6 | - | Babel | $589,411 | - | 270 | - | $2,183 | $589,411 | 1 | 01 Distribution | true | false |
| 7 | 4 | Scoop | $321,456 | -54.8% | 124 | -106 | $2,592 | $4,855,852 | 4 | Medusa Distribuzione | false | false |
| 8 | - | Fascisti su Marte | $180,889 | - | 53 | - | $3,413 | $180,889 | 1 | Fandango | true | false |
| 9 | - | Those Happy Days | $179,682 | - | 124 | - | $1,449 | $179,682 | 1 | Filmauro | true | false |
| 10 | 5 | Miami Vice | $169,048 | -68.4% | 102 | -93 | $1,657 | $4,161,476 | 4 | United International Pictures | false | false |
| 11 | 7 | N (Io e Napoleone) | $115,333 | -69.4% | 58 | -149 | $1,988 | $1,107,978 | 3 | Medusa Distribuzione | false | false |
| 12 | 12 | Golden Door | $107,459 | -48% | 54 | -43 | $1,989 | $2,511,526 | 6 | 01 Distribution | false | false |
| 13 | 9 | Pirates of the Caribbean: Dead Man's Chest | $97,974 | -66.7% | 62 | -68 | $1,580 | $25,053,130 | 7 | Buena Vista International | false | false |
| 14 | 11 | Click | $82,984 | -67.2% | 45 | -50 | $1,844 | $3,020,426 | 5 | Sony Pictures Releasing | false | false |
| 15 | 8 | Fur: An Imaginary Portrait of Diane Arbus | $71,724 | -77.6% | 88 | -107 | $815 | $516,277 | 2 | Nexo | false | false |
| 16 | 6 | The Hoax | $66,890 | -84.8% | 122 | -171 | $548 | $634,345 | 2 | Eagle Pictures | false | false |
| 17 | 10 | Monster House | $54,586 | -81.4% | 102 | -73 | $535 | $861,977 | 3 | Sony Pictures Releasing | false | false |
| 18 | 14 | Little Miss Sunshine | $51,524 | -45.1% | 17 | -17 | $3,030 | $1,123,904 | 6 | 20th Century Fox International | false | false |
| 19 | - | Gardens in Autumn | $34,880 | - | 14 | - | $2,491 | $34,880 | 1 | Mikado Film | true | false |
| 20 | - | Grbavica | $31,233 | - | 26 | - | $1,201 | $31,233 | 1 | Istituto Luce | true | false |
