| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | The Departed | $2,742,542 | -24.5% | 358 | -6 | $7,660 | $15,350,397 | 3 | Entertainment Film Distributors | false | false |
| 2 | 2 | The Devil Wears Prada | $2,556,986 | -26.3% | 448 | +2 | $5,707 | $17,690,923 | 3 | 20th Century Fox International | false | false |
| 3 | - | Barnyard | $1,925,984 | - | 444 | - | $4,337 | $1,925,984 | 1 | United International Pictures | true | false |
| 4 | 3 | Open Season | $1,910,834 | -38.2% | 447 | +2 | $4,274 | $5,891,307 | 2 | Sony Pictures Releasing | false | false |
| 5 | - | The Guardian | $1,556,334 | - | 355 | - | $4,384 | $1,556,334 | 1 | Buena Vista International | true | false |
| 6 | - | The Grudge 2 | $1,456,264 | - | 331 | - | $4,399 | $1,456,264 | 1 | United International Pictures | true | false |
| 7 | 5 | The History Boys | $1,203,259 | -18.4% | 300 | +8 | $4,010 | $3,758,680 | 2 | 20th Century Fox International | false | false |
| 8 | 4 | Click | $1,147,784 | -32.6% | 360 | -19 | $3,188 | $11,615,605 | 4 | Sony Pictures Releasing | false | false |
| 9 | 7 | Hoodwinked! | $666,944 | -30% | 462 | +31 | $1,443 | $7,838,872 | 4 | Momentum Pictures | false | false |
| 10 | - | Don | $548,789 | - | 51 | - | $10,760 | $548,789 | 1 | UTV Motion Pictures | true | false |
| 11 | - | Marie Antoinette | $534,519 | - | 179 | - | $2,986 | $534,519 | 1 | Sony Pictures Releasing | true | false |
| 12 | 6 | The Texas Chainsaw Massacre: The Beginning | $512,162 | -58.8% | 286 | -9 | $1,790 | $2,373,278 | 2 | Entertainment Film Distributors | false | false |
| 13 | 8 | World Trade Center | $343,570 | -57.1% | 228 | -94 | $1,506 | $8,654,950 | 4 | United International Pictures | false | false |
| 14 | 9 | The Queen | $305,029 | -38.9% | 188 | -90 | $1,622 | $12,846,601 | 6 | Pathé | false | false |
| 15 | 10 | Children of Men | $174,713 | -56% | 84 | -114 | $2,079 | $8,733,416 | 5 | United International Pictures | false | false |
| 16 | 13 | Little Miss Sunshine | $130,070 | -24.7% | 49 | -31 | $2,654 | $5,496,786 | 7 | 20th Century Fox International | false | false |
| 17 | - | Jaan-E-Mann: Lets Fall in Love Again | $123,468 | - | 42 | - | $2,939 | $123,468 | 1 | - | true | false |
| 18 | 11 | Stick It | $94,400 | -61.2% | 194 | +35 | $486 | $556,667 | 2 | Buena Vista International | false | false |
| 19 | 12 | Accepted | $56,918 | -74.6% | 62 | -144 | $918 | $1,304,204 | 3 | United International Pictures | false | false |
| 20 | 14 | Volver | $54,895 | -0.5% | 20 | - | $2,744 | $4,992,553 | 9 | Pathé | false | false |
| 21 | 18 | Garfield: A Tail of Two Kitties | $37,569 | +26.5% | 142 | +22 | $264 | $12,182,276 | 14 | 20th Century Fox International | false | false |
| 22 | 37 | Stormbreaker | $32,785 | +514.3% | 156 | +130 | $210 | $12,622,026 | 14 | Entertainment Film Distributors | false | false |
| 23 | - | Varalaaru | $26,696 | - | 3 | - | $8,898 | $26,696 | 1 | Ayngaran International | true | false |
| 24 | 16 | An Inconvenient Truth | $26,106 | -45.1% | 21 | -17 | $1,243 | $1,280,744 | 6 | United International Pictures | false | false |
| 25 | 30 | Over the Hedge | $23,146 | +167% | 73 | +44 | $317 | $24,506,547 | 17 | United International Pictures | false | false |
| 26 | 15 | Little Man | $21,902 | -58.3% | 50 | -39 | $438 | $8,018,844 | 8 | Sony Pictures Releasing | false | false |
| 27 | 20 | Monster House | $18,484 | -19.7% | 67 | -14 | $275 | $12,260,597 | 11 | Sony Pictures Releasing | false | false |
| 28 | 23 | Cars | $12,576 | -29.5% | 38 | -21 | $330 | $30,588,309 | 13 | Buena Vista International | false | false |
| 29 | - | I Saw Ben Barka Get Killed | $11,322 | - | 3 | - | $3,774 | $11,322 | 1 | Artificial Eye | true | false |
| 30 | - | Gypo | $10,992 | - | 7 | - | $1,570 | $10,992 | 1 | Lionsgate | true | false |
| 31 | 22 | Zidane - A 21st Century Portrait | $8,473 | -53.1% | 6 | -6 | $1,412 | $240,409 | 4 | Artificial Eye | false | false |
| 32 | 17 | Talladega Nights: The Ballad of Ricky Bobby | $8,168 | -78.5% | 12 | -43 | $680 | $6,192,216 | 6 | Sony Pictures Releasing | false | false |
| 33 | 41 | A Scanner Darkly | $5,709 | +76.4% | 4 | -2 | $1,427 | $1,764,278 | 10 | Warner Bros. | false | false |
| 34 | 32 | Neil Young: Heart of Gold | $5,097 | -26.9% | 3 | - | $1,699 | $43,014 | 3 | United International Pictures | false | false |
| 35 | 35 | Pirates of the Caribbean: Dead Man's Chest | $4,809 | -24.8% | 2 | -7 | $2,404 | $97,898,145 | 16 | Buena Vista International | false | false |
| 36 | - | Leonard Cohen: I'm Your Man | $4,707 | - | 3 | - | $1,569 | $4,707 | 1 | Lionsgate | true | false |
| 37 | 36 | The Ant Bully | $4,075 | -29.1% | 19 | -2 | $214 | $3,712,625 | 12 | Warner Bros. | false | false |
| 38 | 24 | You, Me and Dupree | $3,564 | -75.5% | 8 | -10 | $445 | $15,185,257 | 9 | United International Pictures | false | false |
| 39 | 38 | Snow Cake | $3,393 | -21.8% | 5 | +2 | $678 | $167,963 | 7 | Momentum Pictures | false | false |
| 40 | 31 | The Wind that Shakes the Barley | $3,188 | -54.3% | 4 | -2 | $797 | $7,132,258 | 18 | Pathé | false | false |
| 41 | 25 | Life and Lyrics | $2,986 | -79.2% | 6 | -12 | $497 | $372,969 | 4 | United International Pictures | false | false |
| 42 | 46 | Quinceañera | $2,401 | +19.9% | 5 | -3 | $480 | $61,318 | 4 | - | false | false |
| 43 | - | Three Times | $2,194 | - | 3 | - | $731 | $154,692 | 12 | Artificial Eye | false | false |
| 44 | 26 | Dil Apna Punjabi | $2,009 | -85.5% | 5 | -4 | $401 | $486,065 | 8 | - | false | false |
| 45 | 21 | New Police Story | $1,943 | -89.9% | 6 | -10 | $323 | $33,404 | 2 | Contender Entertainment Group | false | false |
| 46 | 27 | Waris Shah: Ishq Daa Waaris | $1,922 | -83.1% | 2 | -5 | $961 | $92,672 | 4 | - | false | false |
| 47 | 19 | Idlewild | $1,909 | -93% | 7 | -33 | $272 | $42,376 | 2 | United International Pictures | false | false |
| 48 | 47 | Keane 2006 Re-release | $1,898 | +0.4% | 4 | +2 | $474 | $63,869 | 5 | Soda Pictures | false | false |
| 49 | 43 | Driving Lessons | $1,832 | -33.9% | 3 | -3 | $610 | $250,145 | 7 | Tartan | false | false |
| 50 | 45 | Nina's Heavenly Delights | $1,636 | -25.7% | 2 | - | $818 | $37,383 | 4 | Verve Pictures | false | false |
