| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Pan's Labyrinth | $1,337,716 | -30.8% | 301 | +3 | $4,444 | $4,922,284 | 2 | Warner Bros. | false | false |
| 2 | - | The Black Dahlia | $1,200,282 | - | 239 | - | $5,022 | $1,200,282 | 1 | TriPictures | true | false |
| 3 | 3 | The Devil Wears Prada | $887,235 | -36.9% | 302 | +1 | $2,937 | $6,211,214 | 3 | 20th Century Fox International | false | false |
| 4 | 2 | The Borgia | $885,018 | -38.3% | 322 | -3 | $2,748 | $5,896,627 | 3 | DeAPlaneta | false | false |
| 5 | - | My Name Is Juani | $843,982 | - | 185 | - | $4,562 | $843,982 | 1 | Manga Entertainment | true | false |
| 6 | - | Children of Men | $596,059 | - | 156 | - | $3,820 | $596,059 | 1 | United International Pictures | true | false |
| 7 | 4 | The Guardian | $499,467 | -52.9% | 402 | -4 | $1,242 | $2,405,281 | 2 | Buena Vista International | false | false |
| 8 | - | The Wicker Man | $482,484 | - | 251 | - | $1,922 | $482,484 | 1 | Filmax | true | false |
| 9 | - | Little Miss Sunshine | $426,429 | - | 179 | - | $2,382 | $426,429 | 1 | 20th Century Fox International | true | false |
| 10 | 7 | You, Me and Dupree | $308,041 | -48.1% | 199 | -19 | $1,547 | $1,370,750 | 2 | United International Pictures | false | false |
| 11 | 5 | Click | $306,631 | -55.8% | 240 | -79 | $1,277 | $4,965,209 | 4 | Sony Pictures Releasing | false | false |
| 12 | 6 | Crank | $252,088 | -62.1% | 253 | -6 | $996 | $1,412,662 | 2 | - | false | false |
| 13 | - | Copying Beethoven | $233,765 | - | 91 | - | $2,568 | $233,765 | 1 | Notro Films | true | false |
| 14 | 9 | Hoodwinked! | $214,923 | -41.5% | 168 | -65 | $1,279 | $3,620,865 | 5 | Manga Entertainment | false | false |
| 15 | 8 | World Trade Center | $165,463 | -68.8% | 184 | -132 | $899 | $5,637,869 | 4 | United International Pictures | false | false |
| 16 | - | Running Scared | $136,034 | - | 200 | - | $680 | $136,034 | 1 | Sony Pictures Releasing | true | false |
| 17 | 10 | Captain Alatriste: The Spanish Musketeer | $93,035 | -69.7% | 109 | -135 | $853 | $20,900,190 | 8 | 20th Century Fox International | false | false |
| 18 | 11 | Little Man | $72,470 | -69.5% | 99 | -93 | $732 | $5,987,123 | 6 | Sony Pictures Releasing | false | false |
| 19 | 15 | The Ant Bully | $69,366 | -28.9% | 56 | -47 | $1,238 | $2,181,265 | 7 | Warner Bros. | false | false |
| 20 | 13 | Salvador | $68,210 | -58.8% | 77 | -57 | $885 | $3,235,528 | 6 | Warner Bros. | false | false |
