| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | The Departed | $1,360,996 | -27% | 276 | - | $4,931 | $3,916,721 | 2 | Warner Bros. | false | false |
| 2 | - | BoyTown | $756,605 | - | 202 | - | $3,745 | $756,605 | 1 | Roadshow Films | true | false |
| 3 | 2 | The Devil Wears Prada | $733,318 | -36.3% | 297 | -8 | $2,469 | $10,375,757 | 5 | 20th Century Fox International | false | false |
| 4 | 3 | Little Miss Sunshine | $602,882 | -9.4% | 132 | +15 | $4,567 | $1,754,358 | 3 | Park Circus | false | false |
| 5 | - | Children of Men | $601,029 | - | 164 | - | $3,664 | $601,029 | 1 | United International Pictures | true | false |
| 6 | - | Crank | $327,252 | - | 133 | - | $2,460 | $327,252 | 1 | Hoyts Distribution | true | false |
| 7 | 4 | Step Up | $302,435 | -46.3% | 144 | -10 | $2,100 | $4,254,503 | 4 | United International Pictures | false | false |
| 8 | 11 | Kenny | $284,282 | +5.5% | 124 | - | $2,292 | $4,246,405 | 10 | Madman Entertainment | false | false |
| 9 | 5 | Garfield: A Tail of Two Kitties | $172,727 | -68.3% | 199 | -5 | $867 | $4,929,036 | 7 | 20th Century Fox International | false | false |
| 10 | 8 | The Covenant | $135,608 | -57.2% | 105 | - | $1,291 | $547,714 | 2 | Sony Pictures Releasing | false | false |
| 11 | 7 | World Trade Center | $132,548 | -60.9% | 194 | -12 | $683 | $1,555,367 | 3 | United International Pictures | false | false |
| 12 | 14 | An Inconvenient Truth | $117,015 | -20% | 52 | -4 | $2,250 | $2,185,541 | 6 | United International Pictures | false | false |
| 13 | 6 | Monster House | $114,881 | -72.2% | 177 | -51 | $649 | $5,849,177 | 6 | Sony Pictures Releasing | false | false |
| 14 | 10 | Talladega Nights: The Ballad of Ricky Bobby | $104,556 | -63.8% | 140 | -84 | $746 | $4,401,942 | 5 | Sony Pictures Releasing | false | false |
| 15 | - | Don | $74,398 | - | 12 | - | $6,199 | $74,398 | 1 | MG Distribution | true | false |
| 16 | 9 | The Wild | $73,630 | -75.1% | 155 | -68 | $475 | $2,664,290 | 4 | Buena Vista International | false | false |
| 17 | 17 | A Prairie Home Companion | $72,277 | -21% | 35 | +4 | $2,065 | $370,948 | 3 | Hoyts Distribution | false | false |
| 18 | 12 | Barnyard | $70,517 | -70.3% | 131 | -58 | $538 | $2,966,558 | 5 | United International Pictures | false | false |
| 19 | 16 | Could This Be Love? | $56,213 | -38.8% | 49 | +2 | $1,147 | $187,048 | 2 | Palace Films | false | false |
| 20 | 13 | The Ant Bully | $53,971 | -71.6% | 95 | -75 | $568 | $1,771,214 | 4 | Warner Bros. | false | false |
