| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 2 | The Departed | $3,632,670 | -15.5% | 364 | +1 | $9,979 | $10,465,227 | 2 | Entertainment Film Distributors | false | false |
| 2 | 1 | The Devil Wears Prada | $3,470,180 | -43.2% | 446 | -1 | $7,780 | $12,527,929 | 2 | 20th Century Fox International | false | false |
| 3 | - | Open Season | $3,092,874 | - | 445 | - | $6,950 | $3,092,874 | 1 | Sony Pictures Releasing | true | false |
| 4 | 3 | Click | $1,703,125 | -28.7% | 379 | -21 | $4,493 | $9,687,061 | 3 | Sony Pictures Releasing | false | false |
| 5 | - | The History Boys | $1,474,619 | - | 292 | - | $5,050 | $1,474,619 | 1 | 20th Century Fox International | true | false |
| 6 | - | The Texas Chainsaw Massacre: The Beginning | $1,242,828 | - | 295 | - | $4,212 | $1,242,828 | 1 | Entertainment Film Distributors | true | false |
| 7 | 4 | Hoodwinked! | $952,394 | -44.2% | 431 | -5 | $2,209 | $6,780,599 | 3 | Momentum Pictures | false | false |
| 8 | 5 | World Trade Center | $800,199 | -50.6% | 322 | -91 | $2,485 | $7,808,558 | 3 | United International Pictures | false | false |
| 9 | 6 | The Queen | $499,495 | -47.4% | 278 | -57 | $1,796 | $11,718,118 | 5 | Pathé | false | false |
| 10 | 7 | Children of Men | $397,001 | -54.2% | 198 | -134 | $2,005 | $8,203,140 | 4 | United International Pictures | false | false |
| 11 | - | Stick It | $243,168 | - | 159 | - | $1,529 | $243,168 | 1 | Buena Vista International | true | false |
| 12 | 8 | Accepted | $224,492 | -65.7% | 206 | -43 | $1,089 | $1,124,364 | 2 | United International Pictures | false | false |
| 13 | 9 | Little Miss Sunshine | $172,713 | -45.5% | 80 | -52 | $2,158 | $5,154,158 | 6 | 20th Century Fox International | false | false |
| 14 | 14 | Volver | $55,177 | -31.5% | 20 | -12 | $2,758 | $4,824,138 | 8 | Pathé | false | false |
| 15 | 11 | Little Man | $52,566 | -66.4% | 89 | -107 | $590 | $7,870,685 | 7 | Sony Pictures Releasing | false | false |
| 16 | 13 | An Inconvenient Truth | $47,526 | -46.2% | 38 | -30 | $1,250 | $1,193,589 | 5 | United International Pictures | false | false |
| 17 | 10 | Talladega Nights: The Ballad of Ricky Bobby | $38,022 | -80.6% | 55 | -128 | $691 | $6,074,530 | 5 | Sony Pictures Releasing | false | false |
| 18 | 20 | Garfield: A Tail of Two Kitties | $29,705 | -38.6% | 120 | -2 | $247 | $11,965,821 | 13 | 20th Century Fox International | false | false |
| 19 | - | Idlewild | $27,280 | - | 40 | - | $682 | $27,280 | 1 | United International Pictures | true | false |
| 20 | 16 | Monster House | $23,027 | -64.9% | 81 | -96 | $284 | $12,059,685 | 10 | Sony Pictures Releasing | false | false |
| 21 | - | New Police Story | $19,332 | - | 16 | - | $1,208 | $19,332 | 1 | Contender Entertainment Group | true | false |
| 22 | 22 | Zidane - A 21st Century Portrait | $18,059 | -48.9% | 12 | -8 | $1,504 | $211,323 | 3 | Artificial Eye | false | false |
| 23 | 17 | Cars | $17,833 | -70.6% | 59 | -87 | $302 | $30,129,434 | 12 | Buena Vista International | false | false |
| 24 | 12 | You, Me and Dupree | $14,522 | -84% | 18 | -81 | $806 | $14,954,697 | 8 | United International Pictures | false | false |
| 25 | 15 | Life and Lyrics | $14,374 | -79.8% | 18 | -37 | $798 | $359,415 | 3 | United International Pictures | false | false |
| 26 | 27 | Dil Apna Punjabi | $13,888 | -12.8% | 9 | +2 | $1,543 | $473,745 | 7 | Adlabs Films | false | false |
| 27 | 26 | Waris Shah: Ishq Daa Waaris | $11,401 | -41.4% | 7 | -3 | $1,628 | $85,559 | 3 | - | false | false |
| 28 | - | The Aryan Couple | $11,013 | - | 13 | - | $847 | $11,013 | 1 | Transmedia International Releasing | true | false |
| 29 | 25 | Lage Raho Munna Bhai | $10,930 | -46.6% | 9 | -6 | $1,214 | $1,522,624 | 7 | Eros Worldwide | false | false |
| 30 | 36 | Over the Hedge | $8,668 | -20.5% | 29 | -5 | $298 | $24,128,766 | 16 | United International Pictures | false | false |
| 31 | 31 | The Wind that Shakes the Barley | $6,977 | -48.6% | 6 | -9 | $1,162 | $7,020,611 | 17 | Pathé | false | false |
| 32 | 34 | Neil Young: Heart of Gold | $6,968 | -40% | 3 | -2 | $2,322 | $30,705 | 2 | United International Pictures | false | false |
| 33 | 32 | Mannat | $6,569 | -51% | 6 | -3 | $1,094 | $26,530 | 2 | Eros Worldwide | false | false |
| 34 | 41 | Man Push Cart | $6,515 | -17.3% | 3 | - | $2,171 | $19,295 | 2 | Periscoop Film | false | false |
| 35 | 21 | Pirates of the Caribbean: Dead Man's Chest | $6,398 | -82.6% | 9 | -27 | $710 | $96,472,030 | 15 | Buena Vista International | false | false |
| 36 | 40 | The Ant Bully | $5,747 | -29.1% | 21 | -8 | $273 | $3,648,588 | 11 | Warner Bros. | false | false |
| 37 | 37 | Stormbreaker | $5,337 | -46.1% | 26 | +1 | $205 | $12,404,184 | 13 | Entertainment Film Distributors | false | false |
| 38 | 43 | Snow Cake | $4,338 | -41.6% | 3 | -4 | $1,446 | $157,940 | 6 | Momentum Pictures | false | false |
| 39 | 19 | Dirty Sanchez: The Movie | $4,190 | -92% | 15 | -56 | $279 | $1,208,708 | 4 | Pathé | false | false |
| 40 | - | Ruby & Quentin 2006 Re-release | $4,168 | - | 1 | - | $4,168 | $4,168 | 1 | Cinefrance | true | false |
| 41 | 50 | A Scanner Darkly | $3,236 | -4.7% | 6 | - | $539 | $1,729,198 | 9 | Warner Bros. | false | false |
| 42 | 30 | Zindanggi Rocks | $2,963 | -79.6% | 6 | -4 | $493 | $25,663 | 3 | Eros Worldwide | false | false |
| 43 | 38 | Driving Lessons | $2,772 | -68.6% | 6 | -15 | $462 | $240,338 | 6 | Tartan | false | false |
| 44 | 28 | Brothers of the Head | $2,576 | -83.5% | 10 | -5 | $257 | $28,920 | 2 | Tartan | false | false |
| 45 | - | Nina's Heavenly Delights | $2,203 | - | 2 | - | $1,101 | $34,259 | 3 | Verve Pictures | false | false |
| 46 | 44 | Quinceañera | $2,002 | -70.8% | 8 | -2 | $250 | $56,055 | 3 | - | false | false |
| 47 | 47 | Keane 2006 Re-release | $1,891 | -50.9% | 2 | -1 | $945 | $59,332 | 4 | Soda Pictures | false | false |
| 48 | - | The Pervert's Guide to Cinema | $1,588 | - | 1 | - | $1,588 | $7,152 | 2 | ICA Films | false | false |
| 49 | - | Shanghai Dreams | $1,514 | - | 1 | - | $1,514 | $37,818 | 6 | Artificial Eye | false | false |
| 50 | - | Frozen Land 2006 Re-release | $1,459 | - | 1 | - | $1,459 | $1,459 | 1 | ICA Films | true | false |
