| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Pan's Labyrinth | $1,932,800 | - | 298 | - | $6,485 | $3,063,102 | 1 | Warner Bros. | true | false |
| 2 | 2 | The Borgia | $1,434,683 | -21.1% | 325 | +1 | $4,414 | $4,684,839 | 2 | DeAPlaneta | false | false |
| 3 | 1 | The Devil Wears Prada | $1,405,546 | -34.6% | 301 | - | $4,669 | $4,924,323 | 2 | 20th Century Fox International | false | false |
| 4 | - | The Guardian | $1,061,312 | - | 406 | - | $2,614 | $1,653,841 | 1 | Buena Vista International | true | false |
| 5 | 3 | Click | $694,154 | -45.1% | 319 | -5 | $2,176 | $4,531,770 | 3 | Sony Pictures Releasing | false | false |
| 6 | - | Crank | $664,691 | - | 259 | - | $2,566 | $999,971 | 1 | Aurum Films | true | false |
| 7 | - | You, Me and Dupree | $593,457 | - | 218 | - | $2,722 | $947,271 | 1 | United International Pictures | true | false |
| 8 | 4 | World Trade Center | $530,387 | -57.6% | 316 | -18 | $1,678 | $5,316,204 | 3 | United International Pictures | false | false |
| 9 | 8 | Hoodwinked! | $367,209 | -26.2% | 233 | -20 | $1,576 | $3,342,099 | 4 | Manga Entertainment | false | false |
| 10 | 6 | Captain Alatriste: The Spanish Musketeer | $307,031 | -45.2% | 244 | -85 | $1,258 | $20,550,271 | 7 | 20th Century Fox International | false | false |
| 11 | 7 | Little Man | $237,981 | -52.8% | 192 | -52 | $1,239 | $5,836,734 | 5 | Sony Pictures Releasing | false | false |
| 12 | 5 | Snakes on a Plane | $186,127 | -68.9% | 266 | -8 | $699 | $1,018,981 | 2 | TriPictures | false | false |
| 13 | 11 | Salvador | $165,467 | -41.1% | 134 | -50 | $1,234 | $3,087,809 | 5 | Warner Bros. | false | false |
| 14 | 9 | Cabeza de perro | $156,162 | -46.4% | 191 | -9 | $817 | $611,525 | 2 | Alta Films | false | false |
| 15 | 18 | The Ant Bully | $97,610 | +2.1% | 103 | -45 | $947 | $2,091,595 | 6 | Warner Bros. | false | false |
| 16 | 13 | The Wind that Shakes the Barley | $96,995 | -38% | 74 | -29 | $1,310 | $1,570,172 | 5 | Alta Films | false | false |
| 17 | 10 | The Break-Up | $96,917 | -65.9% | 101 | -103 | $959 | $4,019,063 | 5 | United International Pictures | false | false |
| 18 | 14 | Monster House | $93,320 | -31.7% | 128 | -44 | $729 | $4,946,632 | 7 | Sony Pictures Releasing | false | false |
| 19 | 15 | The Thief Lord | $89,906 | -28.6% | 84 | - | $1,070 | $281,026 | 2 | Flins & Piniculas | false | false |
| 20 | 17 | Vete de mí | $66,545 | -38.5% | 38 | -30 | $1,751 | $459,324 | 3 | United International Pictures | false | false |
