| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | The Departed | $1,865,470 | - | 276 | - | $6,758 | $1,865,470 | 1 | Warner Bros. | true | false |
| 2 | 1 | The Devil Wears Prada | $1,151,731 | -38.7% | 305 | -16 | $3,776 | $9,144,764 | 4 | 20th Century Fox International | false | false |
| 3 | 12 | Little Miss Sunshine | $665,614 | +216.7% | 117 | +8 | $5,689 | $896,113 | 2 | Park Circus | false | false |
| 4 | 2 | Step Up | $562,850 | -33.8% | 154 | - | $3,654 | $3,778,479 | 3 | United International Pictures | false | false |
| 5 | 4 | Garfield: A Tail of Two Kitties | $545,226 | -20.1% | 204 | +1 | $2,672 | $4,639,950 | 6 | 20th Century Fox International | false | false |
| 6 | 5 | Monster House | $412,514 | -35% | 228 | -33 | $1,809 | $5,625,281 | 5 | Sony Pictures Releasing | false | false |
| 7 | 3 | World Trade Center | $339,017 | -50.3% | 206 | +3 | $1,645 | $1,303,538 | 2 | United International Pictures | false | false |
| 8 | - | The Covenant | $316,503 | - | 105 | - | $3,014 | $316,503 | 1 | Sony Pictures Releasing | true | false |
| 9 | 7 | The Wild | $295,796 | -36.2% | 223 | -31 | $1,326 | $2,523,301 | 3 | Buena Vista International | false | false |
| 10 | 6 | Talladega Nights: The Ballad of Ricky Bobby | $288,644 | -44.8% | 224 | -26 | $1,288 | $4,181,830 | 4 | Sony Pictures Releasing | false | false |
| 11 | 10 | Kenny | $269,479 | +7% | 124 | +13 | $2,173 | $3,810,057 | 9 | Madman Entertainment | false | false |
| 12 | 8 | Barnyard | $237,310 | -46.4% | 189 | -7 | $1,255 | $2,830,887 | 4 | United International Pictures | false | false |
| 13 | 9 | The Ant Bully | $190,067 | -32.7% | 170 | -28 | $1,118 | $1,661,896 | 3 | Warner Bros. | false | false |
| 14 | 13 | An Inconvenient Truth | $146,249 | -21.9% | 56 | -2 | $2,611 | $1,974,297 | 5 | United International Pictures | false | false |
| 15 | 11 | Stormbreaker | $129,056 | -41.8% | 130 | -44 | $992 | $1,767,907 | 4 | Roadshow Films | false | false |
| 16 | - | Could This Be Love? | $91,890 | - | 47 | - | $1,955 | $92,888 | 1 | Palace Films | true | false |
| 17 | 15 | A Prairie Home Companion | $91,523 | -20% | 31 | - | $2,952 | $264,386 | 2 | Hoyts Distribution | false | false |
| 18 | 18 | Material Girls | $45,744 | -47.9% | 65 | -29 | $703 | $1,298,934 | 5 | Hoyts Distribution | false | false |
| 19 | 16 | John Tucker Must Die | $45,153 | -53.2% | 64 | -36 | $705 | $2,813,118 | 6 | 20th Century Fox International | false | false |
| 20 | 14 | Nacho Libre | $41,494 | -68% | 61 | -107 | $680 | $2,385,131 | 5 | United International Pictures | false | false |
