| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | The Departed | $30,757,790 | - | 3,017 | - | $10,194 | $30,757,790 | 1 | Warner Bros. | true | false |
| 2 | - | The Texas Chainsaw Massacre: The Beginning | $20,084,000 | - | 2,820 | - | $7,121 | $20,084,000 | 1 | New Line Cinema | true | true |
| 3 | - | Open Season | $17,900,758 | - | 3,833 | - | $4,670 | $46,029,498 | 2 | Sony Pictures Releasing | false | false |
| 4 | - | Employee of the Month | $12,586,279 | - | 2,579 | - | $4,880 | $12,586,279 | 1 | Lionsgate | true | false |
| 5 | - | The Guardian | $10,624,174 | - | 3,241 | - | $3,278 | $33,375,891 | 2 | Walt Disney Studios Motion Pictures | false | false |
| 6 | - | Jackass Number Two | $7,346,428 | - | 3,007 | - | $2,443 | $63,639,799 | 3 | Paramount Pictures | false | false |
| 7 | - | School for Scoundrels | $3,850,708 | - | 3,007 | - | $1,280 | $14,405,486 | 2 | - | false | false |
| 8 | - | Gridiron Gang | $2,499,920 | - | 2,228 | - | $1,122 | $36,820,566 | 4 | Sony Pictures Releasing | false | false |
| 9 | - | The Illusionist | $2,142,944 | - | 1,149 | - | $1,865 | $34,384,956 | 8 | Yari Film Group Releasing | false | false |
| 10 | - | Trailer Park Boys: The Movie | $1,467,000 | - | 181 | - | $8,104 | $1,467,000 | 1 | Alliance Atlantis Vivafilm | true | true |
| 11 | - | Little Miss Sunshine | $1,439,385 | - | 824 | - | $1,746 | $55,170,684 | 11 | - | false | false |
| 12 | - | Flyboys | $1,182,146 | - | 1,471 | - | $803 | $11,976,720 | 3 | Metro-Goldwyn-Mayer (MGM) | false | false |
| 13 | - | Facing the Giants | $1,147,000 | - | 418 | - | $2,744 | $2,890,000 | 2 | IDP Distribution | false | true |
| 14 | - | The Science of Sleep | $767,934 | - | 221 | - | $3,474 | $2,791,726 | 3 | Warner Independent Pictures (WIP) | false | false |
| 15 | - | The Black Dahlia | $632,165 | - | 930 | - | $679 | $22,107,535 | 4 | Universal Pictures | false | false |
| 16 | - | The Queen | $475,000 | - | 11 | - | $43,181 | $708,000 | 2 | Miramax | false | true |
| 17 | - | The Covenant | $463,419 | - | 691 | - | $670 | $23,117,263 | 5 | Screen Gems | false | false |
| 18 | - | Invincible | $441,000 | - | 551 | - | $800 | $57,060,000 | 7 | Walt Disney Studios Motion Pictures | false | true |
| 19 | - | The Last Kiss | $419,890 | - | 403 | - | $1,041 | $11,265,307 | 4 | DreamWorks | false | false |
| 20 | - | Barnyard | $411,347 | - | 523 | - | $786 | $71,767,070 | 10 | Paramount Pictures | false | false |
| 21 | - | Monster House | $395,758 | - | 331 | - | $1,195 | $73,034,593 | 12 | Sony Pictures Releasing | false | false |
| 22 | - | Talladega Nights: The Ballad of Ricky Bobby | $347,964 | - | 476 | - | $731 | $147,866,245 | 10 | Sony Pictures Releasing | false | false |
| 23 | - | The Last King of Scotland | $338,647 | - | 30 | - | $11,288 | $579,654 | 2 | - | false | false |
| 24 | - | Superman Returns | $331,938 | - | 388 | - | $855 | $199,429,968 | 15 | Warner Bros. | false | false |
| 25 | - | Everyone's Hero | $326,984 | - | 595 | - | $549 | $13,916,481 | 4 | Twentieth Century Fox | false | false |
| 26 | - | Fearless | $305,859 | - | 1,617 | - | $189 | $22,057,186 | 3 | Rogue Pictures | false | false |
| 27 | - | All the King's Men | $285,993 | - | 680 | - | $420 | $7,052,190 | 3 | Sony Pictures Releasing | false | false |
| 28 | - | Deep Sea | $186,700 | - | 35 | - | $5,334 | $19,638,349 | 32 | Warner Bros. | false | false |
| 29 | - | The Devil Wears Prada | $181,974 | - | 196 | - | $928 | $124,135,622 | 15 | Twentieth Century Fox | false | false |
| 30 | - | Accepted | $160,650 | - | 253 | - | $634 | $36,208,365 | 8 | Universal Pictures | false | false |
| 31 | - | The U.S. vs. John Lennon | $148,625 | - | 58 | - | $2,562 | $571,296 | 4 | Lionsgate | false | false |
| 32 | - | The Wicker Man | $136,114 | - | 238 | - | $571 | $23,362,839 | 6 | Warner Bros. | false | false |
| 33 | - | Crank | $135,586 | - | 164 | - | $826 | $27,788,226 | 6 | Lionsgate | false | false |
| 34 | - | The Protector | $81,603 | - | 145 | - | $562 | $11,673,125 | 5 | Dragon Dynasty | false | false |
| 35 | - | World Trade Center | $72,658 | - | 117 | - | $621 | $70,126,397 | 9 | Paramount Pictures | false | false |
| 36 | - | The Descent | $48,765 | - | 156 | - | $312 | $26,012,111 | 10 | Lionsgate | false | false |
| 37 | - | An Inconvenient Truth | $40,158 | - | 86 | - | $466 | $23,733,497 | 20 | Paramount Classics | false | false |
| 38 | - | The Ant Bully | $26,570 | - | 53 | - | $501 | $27,621,559 | 11 | Warner Bros. | false | false |
| 39 | - | Beerfest | $20,050 | - | 40 | - | $501 | $19,076,119 | 7 | Warner Bros. | false | false |
| 40 | - | Pulse | $16,988 | - | 39 | - | $435 | $20,261,128 | 9 | - | false | false |
| 41 | - | Love's Abiding Joy | $14,683 | - | 207 | - | $70 | $160,578 | 1 | The Bigger Picture | true | false |
| 42 | - | Material Girls | $12,892 | - | 30 | - | $429 | $11,402,448 | 8 | Metro-Goldwyn-Mayer (MGM) | false | false |
| 43 | - | A Prairie Home Companion | $7,265 | - | 20 | - | $363 | $20,339,219 | 18 | Picturehouse | false | false |
| 44 | - | Kettle of Fish | $6,016 | - | 3 | - | $2,005 | $6,016 | 1 | - | true | false |
| 45 | - | A Scanner Darkly | $3,338 | - | 10 | - | $333 | $5,498,450 | 14 | Warner Independent Pictures (WIP) | false | false |
