| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | The Devil Wears Prada | $2,150,524 | - | 301 | - | $7,144 | $2,150,524 | 1 | 20th Century Fox International | true | false |
| 2 | - | The Borgia | $1,819,284 | - | 324 | - | $5,615 | $1,819,284 | 1 | DeAPlaneta | true | false |
| 3 | 2 | Click | $1,263,673 | -25.9% | 324 | +9 | $3,900 | $3,257,226 | 2 | Sony Pictures Releasing | false | false |
| 4 | 1 | World Trade Center | $1,252,334 | -47.9% | 334 | +9 | $3,749 | $4,196,576 | 2 | United International Pictures | false | false |
| 5 | - | Snakes on a Plane | $599,431 | - | 274 | - | $2,187 | $599,431 | 1 | TriPictures | true | false |
| 6 | 3 | Captain Alatriste: The Spanish Musketeer | $560,112 | -37.3% | 329 | -68 | $1,702 | $20,077,664 | 6 | 20th Century Fox International | false | false |
| 7 | 5 | Little Man | $503,784 | -31.1% | 244 | -6 | $2,064 | $5,434,853 | 4 | Sony Pictures Releasing | false | false |
| 8 | 4 | Hoodwinked! | $497,903 | -32.4% | 253 | -5 | $1,967 | $2,700,539 | 3 | Manga Entertainment | false | false |
| 9 | - | Cabeza de perro | $291,081 | - | 200 | - | $1,455 | $291,081 | 1 | Alta Films | true | false |
| 10 | 6 | The Break-Up | $283,952 | -45% | 204 | -20 | $1,391 | $3,834,746 | 4 | United International Pictures | false | false |
| 11 | 8 | Salvador | $280,969 | -34.4% | 184 | -6 | $1,527 | $2,763,223 | 4 | Warner Bros. | false | false |
| 12 | 7 | My Super Ex-Girlfriend | $211,698 | -54.6% | 258 | -41 | $820 | $1,899,823 | 3 | 20th Century Fox International | false | false |
| 13 | 9 | The Wind that Shakes the Barley | $156,326 | -31.4% | 103 | -5 | $1,517 | $1,383,921 | 4 | Alta Films | false | false |
| 14 | 10 | Monster House | $136,695 | -39.7% | 172 | -59 | $794 | $4,820,442 | 6 | Sony Pictures Releasing | false | false |
| 15 | - | The Thief Lord | $125,935 | - | 84 | - | $1,499 | $125,935 | 1 | Flins & Piniculas | true | false |
| 16 | 11 | The Lazarus Child | $108,345 | -51.1% | 124 | -20 | $873 | $917,437 | 3 | Aurum Films | false | false |
| 17 | 13 | Vete de mí | $108,174 | -28% | 68 | -4 | $1,590 | $328,356 | 2 | United International Pictures | false | false |
| 18 | 14 | The Ant Bully | $95,576 | -35.8% | 148 | -53 | $645 | $1,943,857 | 5 | Warner Bros. | false | false |
| 19 | 12 | Miami Vice | $94,697 | -56.5% | 100 | -119 | $946 | $4,267,265 | 5 | United International Pictures | false | false |
| 20 | 18 | Garfield: A Tail of Two Kitties | $67,677 | -38.5% | 133 | -57 | $508 | $8,274,592 | 7 | 20th Century Fox International | false | false |
