| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Little Man | $169,985 | - | 44 | - | $3,863 | $169,985 | 1 | Sony Pictures Releasing | true | false |
| 2 | 2 | Mrs Palfrey at the Claremont | $91,260 | -12.1% | 33 | - | $2,765 | $393,717 | 3 | Rialto Distribution | false | false |
| 3 | - | Silent Hill | $85,843 | - | 28 | - | $3,065 | $85,843 | 1 | United International Pictures | true | false |
| 4 | 1 | Snakes on a Plane | $69,213 | -39.8% | 41 | - | $1,688 | $225,645 | 2 | Roadshow Films | false | false |
| 5 | 3 | My Super Ex-Girlfriend | $48,614 | -42.1% | 40 | - | $1,215 | $323,129 | 3 | 20th Century Fox International | false | false |
| 6 | 4 | Hoodwinked! | $46,683 | -36.5% | 50 | +1 | $933 | $593,579 | 5 | Roadshow Films | false | false |
| 7 | 5 | Pirates of the Caribbean: Dead Man's Chest | $44,378 | -32.7% | 54 | -10 | $821 | $4,470,373 | 9 | Buena Vista International | false | false |
| 8 | 10 | Thank You for Smoking | $43,029 | +14.2% | 10 | - | $4,302 | $130,300 | 2 | 20th Century Fox International | false | false |
| 9 | 8 | United 93 | $34,841 | -28.4% | 25 | - | $1,393 | $192,542 | 3 | United International Pictures | false | false |
| 10 | 7 | Fearless | $34,765 | -32.8% | 20 | +1 | $1,738 | $126,059 | 2 | United International Pictures | false | false |
| 11 | 6 | Miami Vice | $30,105 | -47.2% | 36 | -7 | $836 | $575,677 | 4 | United International Pictures | false | false |
| 12 | 9 | You, Me and Dupree | $22,676 | -40.1% | 35 | -3 | $647 | $731,561 | 6 | United International Pictures | false | false |
| 13 | 11 | Take the Lead | $18,443 | -27.2% | 38 | +4 | $485 | $1,198,356 | 10 | Roadshow Films | false | false |
| 14 | 12 | As It Is in Heaven | $13,720 | -10.7% | 14 | -1 | $980 | $398,743 | 36 | Rialto Distribution | false | false |
| 15 | 13 | The Lake House | $10,784 | -26.3% | 23 | +3 | $468 | $465,826 | 7 | Roadshow Films | false | false |
| 16 | 14 | Ballets Russes | $7,405 | -25.5% | 5 | +1 | $1,481 | $50,842 | 4 | Hopscotch Films | false | false |
| 17 | 16 | Breakfast on Pluto | $6,309 | -22.5% | 13 | +1 | $485 | $92,944 | 6 | Dendy Films | false | false |
| 18 | 17 | Over the Hedge | $5,941 | -25.3% | 35 | -8 | $169 | $2,124,771 | 11 | United International Pictures | false | false |
| 19 | 18 | Confetti | $4,569 | -9.1% | 15 | -1 | $304 | $129,091 | 7 | 20th Century Fox International | false | false |
| 20 | 19 | Cars | $3,545 | -27.5% | 20 | -9 | $177 | $2,207,860 | 13 | Buena Vista International | false | false |
