| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Mission: Impossible III | $9,909,735 | - | 512 | - | $19,354 | $9,909,735 | 1 | United International Pictures | true | false |
| 2 | - | Confetti | $1,170,208 | - | 300 | - | $3,900 | $1,170,208 | 1 | 20th Century Fox International | true | false |
| 3 | 1 | Ice Age: The Meltdown | $1,076,973 | -46.4% | 467 | -18 | $2,306 | $51,233,606 | 5 | 20th Century Fox International | false | false |
| 4 | 3 | Silent Hill | $636,331 | -49% | 300 | -8 | $2,121 | $5,445,183 | 3 | Pathé | false | false |
| 5 | 2 | 16 Blocks | $571,557 | -59.8% | 302 | +1 | $1,892 | $3,011,704 | 2 | Warner Bros. | false | false |
| 6 | 4 | Scary Movie 4 | $361,137 | -63.6% | 314 | -95 | $1,150 | $10,384,011 | 4 | Buena Vista International | false | false |
| 7 | 5 | American Dreamz | $337,264 | -63.8% | 278 | -78 | $1,213 | $3,725,605 | 3 | United International Pictures | false | false |
| 8 | 6 | Slither | $299,359 | -66.4% | 288 | -33 | $1,039 | $1,809,149 | 2 | Entertainment Film Distributors | false | false |
| 9 | 8 | She's the Man | $243,473 | -54.1% | 226 | -66 | $1,077 | $8,027,251 | 5 | Entertainment Film Distributors | false | false |
| 10 | 7 | Inside Man | $194,277 | -65.7% | 119 | -102 | $1,632 | $14,608,015 | 7 | United International Pictures | false | false |
| 11 | - | 36 China Town | $153,013 | - | 34 | - | $4,500 | $153,013 | 1 | Tip Top Entertainment (TTE) | true | false |
| 12 | 10 | Eight Below | $124,019 | -65.9% | 278 | -114 | $446 | $1,884,999 | 3 | Buena Vista International | false | false |
| 13 | 9 | Take the Lead | $107,920 | -76.6% | 127 | -116 | $849 | $4,043,940 | 5 | Entertainment Film Distributors | false | false |
| 14 | 11 | An American Haunting | $73,903 | -77.6% | 90 | -111 | $821 | $3,240,258 | 4 | Lionsgate | false | false |
| 15 | 13 | The Squid and the Whale | $70,147 | -41.6% | 24 | - | $2,922 | $933,254 | 5 | Sony Pictures Releasing | false | false |
| 16 | 14 | The Shaggy Dog | $69,427 | -40.1% | 162 | -78 | $428 | $5,188,279 | 6 | Buena Vista International | false | false |
| 17 | - | Love + Hate | $42,699 | - | 44 | - | $970 | $42,699 | 1 | Verve Pictures | true | false |
| 18 | 21 | Yours, Mine & Ours | $31,224 | -34.2% | 86 | -32 | $363 | $2,397,196 | 6 | Sony Pictures Releasing | false | false |
| 19 | 12 | Tristan + Isolde | $31,196 | -86.8% | 44 | -159 | $709 | $1,094,782 | 3 | 20th Century Fox International | false | false |
| 20 | 28 | Enron: The Smartest Guys in the Room | $29,364 | -21% | 6 | - | $4,894 | $98,611 | 2 | Lionsgate | false | false |
| 21 | 24 | Walk the Line | $27,579 | -32.9% | 30 | -7 | $919 | $18,607,942 | 14 | 20th Century Fox International | false | false |
| 22 | 15 | The Mistress of Spices | $25,135 | -76.7% | 25 | -20 | $1,005 | $421,870 | 3 | Entertainment Film Distributors | false | false |
| 23 | 16 | Humko Deewana Kar Gaye | $24,842 | -65.6% | 24 | -1 | $1,035 | $848,338 | 4 | UTV Motion Pictures | false | false |
| 24 | - | The Devil and Daniel Johnston | $22,513 | - | 10 | - | $2,251 | $22,513 | 1 | Tartan | true | false |
| 25 | 30 | Syriana | $21,166 | -26.2% | 20 | - | $1,058 | $6,990,072 | 10 | Warner Bros. | false | false |
| 26 | 20 | Junebug | $19,762 | -60.9% | 7 | -13 | $2,823 | $330,890 | 4 | Miracle Films | false | false |
| 27 | - | The Magician | $18,218 | - | 18 | - | $1,012 | $18,218 | 1 | Miracle Films | true | false |
| 28 | 25 | Transamerica | $17,875 | -56% | 15 | -18 | $1,191 | $1,303,090 | 7 | Pathé | false | false |
| 29 | - | The Little Polar Bear 2: The Mysterious Island | $16,479 | - | 67 | - | $245 | $969,294 | 13 | Warner Bros. | false | false |
| 30 | 36 | Ballets Russes | $16,033 | -28% | 7 | +3 | $2,290 | $108,391 | 3 | Revolver Entertainment | false | false |
| 31 | 35 | Capote | $15,928 | -28.7% | 24 | -3 | $663 | $2,761,979 | 11 | Sony Pictures Releasing | false | false |
| 32 | 42 | Deep Sea | $15,692 | +7.4% | 1 | - | $15,692 | $434,409 | 10 | IMAX | false | false |
| 33 | 22 | The Pink Panther | $14,610 | -66% | 55 | -22 | $265 | $11,100,542 | 8 | 20th Century Fox International | false | false |
| 34 | - | V for Vendetta | $13,114 | - | 5 | - | $2,622 | $6,557,761 | - | Warner Bros. | - | false |
| 35 | - | Fateless | $12,900 | - | 4 | - | $3,225 | $12,900 | 1 | - | true | false |
| 36 | 17 | Freedomland | $12,653 | -79.7% | 25 | -53 | $506 | $124,780 | 2 | Sony Pictures Releasing | false | false |
| 37 | 26 | Hostel | $11,983 | -70.2% | 18 | -30 | $665 | $7,736,178 | 7 | Sony Pictures Releasing | false | false |
| 38 | 34 | The Three Burials of Melquiades Estrada | $11,721 | -47.6% | 13 | -11 | $901 | $657,595 | 6 | Optimum Releasing | false | false |
| 39 | 41 | Tsotsi | $10,886 | -27.7% | 12 | -8 | $907 | $1,381,887 | 8 | Momentum Pictures | false | false |
| 40 | 37 | U-Carmen eKhayelitsha | $10,564 | -45.1% | 8 | -1 | $1,320 | $79,539 | 3 | Tartan | false | false |
| 41 | 40 | Pierrepoint: The Last Hangman | $9,666 | -45.3% | 11 | -2 | $878 | $333,634 | 5 | Lionsgate | false | false |
| 42 | 33 | Paradise Now | $8,572 | -62.9% | 6 | -2 | $1,428 | $187,109 | 4 | Warner Bros. | false | false |
| 43 | 23 | Failure to Launch | $8,498 | -79.7% | 6 | -31 | $1,416 | $5,418,189 | 6 | United International Pictures | false | false |
| 44 | 18 | Darna Zaroori Hai | $8,021 | -85.9% | 10 | -9 | $802 | $104,314 | 2 | Tip Top Entertainment (TTE) | false | false |
| 45 | 27 | C.R.A.Z.Y. | $7,955 | -78.7% | 5 | -23 | $1,591 | $150,684 | 3 | Soda Pictures | false | false |
| 46 | 19 | Alien Autopsy | $7,452 | -86% | 19 | -76 | $392 | $4,009,720 | 5 | Warner Bros. | false | false |
| 47 | 44 | Shooting Dogs 2006 Re-release | $7,382 | -30.4% | 8 | -4 | $922 | $262,904 | 6 | Metrodome Distribution | false | false |
| 48 | 32 | The White Countess | $7,061 | -73.2% | 22 | -18 | $320 | $540,512 | 6 | Sony Pictures Releasing | false | false |
| 49 | - | Romance & Cigarettes | $7,044 | - | 5 | - | $1,408 | $392,174 | 7 | Icon Film Distribution Australia | false | false |
