| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Ice Age: The Meltdown | $2,009,009 | -40.2% | 485 | -4 | $4,142 | $47,906,948 | 4 | 20th Century Fox International | false | false |
| 2 | - | 16 Blocks | $1,421,498 | - | 301 | - | $4,722 | $1,421,498 | 1 | Warner Bros. | true | false |
| 3 | 2 | Silent Hill | $1,246,846 | -29.4% | 308 | - | $4,048 | $3,992,336 | 2 | Pathé | false | false |
| 4 | 3 | Scary Movie 4 | $993,134 | -40% | 409 | +28 | $2,428 | $9,344,901 | 3 | Buena Vista International | false | false |
| 5 | 4 | American Dreamz | $931,648 | -24.3% | 356 | +2 | $2,616 | $2,763,231 | 2 | United International Pictures | false | false |
| 6 | - | Slither | $891,487 | - | 321 | - | $2,777 | $891,487 | 1 | Entertainment Film Distributors | true | false |
| 7 | 8 | Inside Man | $566,903 | -10.3% | 221 | -19 | $2,565 | $13,936,089 | 6 | United International Pictures | false | false |
| 8 | 6 | She's the Man | $530,527 | -19.6% | 292 | -5 | $1,816 | $7,313,322 | 4 | Entertainment Film Distributors | false | false |
| 9 | 7 | Take the Lead | $460,626 | -27.2% | 243 | -58 | $1,895 | $3,599,761 | 4 | Entertainment Film Distributors | false | false |
| 10 | 5 | Eight Below | $363,265 | -50.7% | 392 | -5 | $926 | $1,367,609 | 2 | Buena Vista International | false | false |
| 11 | 9 | An American Haunting | $329,982 | -33.8% | 201 | -46 | $1,641 | $2,947,127 | 3 | Lionsgate | false | false |
| 12 | 10 | Tristan + Isolde | $235,795 | -41% | 203 | -42 | $1,161 | $897,764 | 2 | 20th Century Fox International | false | false |
| 13 | 15 | The Squid and the Whale | $120,120 | +16.8% | 24 | +5 | $5,005 | $760,641 | 4 | Sony Pictures Releasing | false | false |
| 14 | 11 | The Shaggy Dog | $116,001 | -38.8% | 240 | -72 | $483 | $4,938,135 | 5 | Buena Vista International | false | false |
| 15 | 12 | The Mistress of Spices | $108,078 | -29.1% | 45 | -11 | $2,401 | $332,099 | 2 | Entertainment Film Distributors | false | false |
| 16 | 14 | Humko Deewana Kar Gaye | $72,269 | -36.9% | 25 | -12 | $2,890 | $768,084 | 3 | UTV Motion Pictures | false | false |
| 17 | - | Freedomland | $62,274 | - | 78 | - | $798 | $62,274 | 1 | Sony Pictures Releasing | true | false |
| 18 | - | Darna Zaroori Hai | $57,080 | - | 19 | - | $3,004 | $57,080 | 1 | - | true | false |
| 19 | 13 | Alien Autopsy | $53,154 | -62.9% | 95 | -102 | $559 | $3,918,998 | 4 | Warner Bros. | false | false |
| 20 | 20 | Junebug | $50,582 | -5.3% | 20 | - | $2,529 | $269,770 | 3 | Miracle Films | false | false |
| 21 | 19 | Yours, Mine & Ours | $47,421 | -32.5% | 118 | -40 | $401 | $2,296,917 | 5 | Sony Pictures Releasing | false | false |
| 22 | 16 | The Pink Panther | $43,004 | -53.1% | 77 | -89 | $558 | $10,933,267 | 7 | 20th Century Fox International | false | false |
| 23 | 17 | Failure to Launch | $41,896 | -50% | 37 | -47 | $1,132 | $5,361,134 | 5 | United International Pictures | false | false |
| 24 | 23 | Walk the Line | $41,088 | -6.2% | 37 | -6 | $1,110 | $18,363,172 | 13 | 20th Century Fox International | false | false |
| 25 | 21 | Transamerica | $40,644 | -10.1% | 33 | +10 | $1,231 | $1,237,938 | 6 | Pathé | false | false |
| 26 | 18 | Hostel | $40,224 | -44.6% | 48 | -44 | $838 | $7,630,984 | 6 | Sony Pictures Releasing | false | false |
| 27 | 22 | C.R.A.Z.Y. | $37,388 | -15.5% | 28 | +11 | $1,335 | $112,834 | 2 | Soda Pictures | false | false |
| 28 | - | Enron: The Smartest Guys in the Room | $37,182 | - | 6 | - | $6,197 | $37,182 | 1 | Lionsgate | true | false |
| 29 | - | V for Vendetta | $32,964 | - | 11 | - | $2,996 | $6,461,407 | - | Warner Bros. | - | false |
| 30 | 31 | Syriana | $28,671 | +6.5% | 20 | -3 | $1,433 | $6,879,692 | 9 | Warner Bros. | false | false |
| 31 | 24 | Pyare Mohan | $27,479 | -35.3% | 14 | -1 | $1,962 | $91,643 | 2 | Eros Worldwide | false | false |
| 32 | 29 | The White Countess | $26,386 | -11.8% | 40 | +14 | $659 | $486,279 | 5 | Sony Pictures Releasing | false | false |
| 33 | 28 | Paradise Now | $23,101 | -27.4% | 8 | - | $2,887 | $156,883 | 3 | Warner Bros. | false | false |
| 34 | 27 | The Three Burials of Melquiades Estrada | $22,375 | -33.6% | 24 | +4 | $932 | $621,792 | 5 | Optimum Releasing | false | false |
| 35 | 33 | Capote | $22,345 | -12.3% | 27 | +3 | $827 | $2,694,919 | 10 | Sony Pictures Releasing | false | false |
| 36 | 35 | Ballets Russes | $22,263 | -4.1% | 4 | +1 | $5,565 | $66,806 | 2 | Revolver Entertainment | false | false |
| 37 | 36 | U-Carmen eKhayelitsha | $19,241 | -11.7% | 9 | - | $2,137 | $53,241 | 2 | Tartan | false | false |
| 38 | - | Don't Come Knocking | $19,181 | - | 10 | - | $1,918 | $19,181 | 1 | Sony Pictures Releasing | true | false |
| 39 | 32 | Firewall | $18,381 | -30.8% | 23 | -6 | $799 | $2,234,517 | 5 | Warner Bros. | false | false |
| 40 | 30 | Pierrepoint: The Last Hangman | $17,675 | -38.5% | 13 | -5 | $1,359 | $301,320 | 4 | Lionsgate | false | false |
| 41 | 38 | Tsotsi | $15,061 | -19.6% | 20 | +5 | $753 | $1,343,245 | 7 | Momentum Pictures | false | false |
| 42 | 34 | Deep Sea | $14,610 | -41.6% | 1 | - | $14,610 | $396,251 | 9 | IMAX | false | false |
| 43 | 25 | Rollin' with the Nines | $14,579 | -63% | 21 | -24 | $694 | $75,700 | 2 | Maiden Voyage Pictures | false | false |
| 44 | 45 | Shooting Dogs 2006 Re-release | $10,604 | -12% | 12 | -2 | $883 | $240,705 | 5 | - | false | false |
| 45 | - | Greyfriars Bobby: The True Story of a Dog | $10,394 | - | 40 | - | $259 | $700,805 | 12 | The Works UK Distribution | false | false |
| 46 | - | The World's Fastest Indian | $10,279 | - | 17 | - | $604 | $764,873 | 8 | Icon Film Distribution | false | false |
| 47 | 44 | Caché | $10,168 | -17.8% | 5 | -4 | $2,033 | $2,552,623 | 14 | Artificial Eye | false | false |
| 48 | 41 | Good Night, and Good Luck. | $9,878 | -38.4% | 10 | -3 | $987 | $4,226,547 | 11 | Redbus Film Distribution | false | false |
| 49 | - | The Amateurs | $9,308 | - | 15 | - | $620 | $9,308 | 1 | United International Pictures | true | false |
