| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Ice Age: The Meltdown | $3,361,149 | -47.5% | 489 | -14 | $6,873 | $43,981,219 | 3 | 20th Century Fox International | false | false |
| 2 | - | Silent Hill | $1,767,083 | - | 308 | - | $5,737 | $1,767,083 | 1 | Pathé | true | false |
| 3 | 2 | Scary Movie 4 | $1,655,415 | -42.9% | 381 | -4 | $4,344 | $7,507,796 | 2 | Buena Vista International | false | false |
| 4 | - | American Dreamz | $1,230,622 | - | 354 | - | $3,476 | $1,230,622 | 1 | United International Pictures | true | false |
| 5 | - | Eight Below | $736,859 | - | 397 | - | $1,856 | $736,859 | 1 | Buena Vista International | true | false |
| 6 | 5 | She's the Man | $659,565 | -38% | 297 | -9 | $2,220 | $6,453,076 | 3 | Entertainment Film Distributors | false | false |
| 7 | 4 | Take the Lead | $632,945 | -42.6% | 301 | - | $2,102 | $2,752,398 | 3 | Entertainment Film Distributors | false | false |
| 8 | 3 | Inside Man | $632,167 | -44.3% | 240 | -81 | $2,634 | $12,729,768 | 5 | United International Pictures | false | false |
| 9 | 6 | An American Haunting | $498,719 | -48.1% | 247 | -22 | $2,019 | $2,300,134 | 2 | Lionsgate | false | false |
| 10 | - | Tristan + Isolde | $399,382 | - | 245 | - | $1,630 | $399,382 | 1 | 20th Century Fox International | true | false |
| 11 | 9 | The Shaggy Dog | $189,521 | -44.3% | 312 | -118 | $607 | $4,687,675 | 4 | Buena Vista International | false | false |
| 12 | - | The Mistress of Spices | $152,464 | - | 56 | - | $2,722 | $152,464 | 1 | Entertainment Film Distributors | true | false |
| 13 | 7 | Alien Autopsy | $143,345 | -74.4% | 197 | -203 | $727 | $3,726,928 | 3 | Warner Bros. | false | false |
| 14 | 10 | Humko Deewana Kar Gaye | $114,587 | -63.1% | 37 | -1 | $3,096 | $621,718 | 2 | UTV Motion Pictures | false | false |
| 15 | 14 | The Squid and the Whale | $102,817 | -16.5% | 19 | +1 | $5,411 | $556,557 | 3 | Sony Pictures Releasing | false | false |
| 16 | 12 | The Pink Panther | $91,650 | -62% | 166 | -106 | $552 | $10,615,752 | 6 | 20th Century Fox International | false | false |
| 17 | 8 | Failure to Launch | $83,815 | -77.2% | 84 | -195 | $997 | $5,117,188 | 4 | United International Pictures | false | false |
| 18 | 11 | Hostel | $72,648 | -74% | 92 | -125 | $789 | $7,373,762 | 5 | Sony Pictures Releasing | false | false |
| 19 | 13 | Yours, Mine & Ours | $70,203 | -56.4% | 158 | -82 | $444 | $2,189,332 | 4 | Sony Pictures Releasing | false | false |
| 20 | - | Junebug | $53,435 | - | 20 | - | $2,671 | $177,684 | 2 | Miracle Films | false | false |
| 21 | 18 | Transamerica | $45,217 | -50% | 23 | -10 | $1,965 | $1,136,372 | 5 | Pathé | false | false |
| 22 | - | C.R.A.Z.Y. | $44,223 | - | 17 | - | $2,601 | $44,223 | 1 | Soda Pictures | true | false |
| 23 | - | Walk the Line | $43,797 | - | 43 | - | $1,018 | $17,855,431 | 12 | 20th Century Fox International | false | false |
| 24 | - | Pyare Mohan | $42,475 | - | 15 | - | $2,831 | $42,475 | 1 | Eros Worldwide | true | false |
| 25 | - | Rollin' with the Nines | $39,350 | - | 45 | - | $874 | $39,350 | 1 | Maiden Voyage Pictures | true | false |
| 26 | - | V for Vendetta | $35,306 | - | 22 | - | $1,604 | $6,258,737 | - | Warner Bros. | - | false |
| 27 | 20 | The Three Burials of Melquiades Estrada | $33,703 | -53.2% | 20 | -8 | $1,685 | $564,667 | 4 | Optimum Releasing | false | false |
| 28 | - | Paradise Now | $31,814 | - | 8 | - | $3,976 | $108,439 | 2 | Warner Bros. | false | false |
| 29 | - | The White Countess | $29,929 | - | 26 | - | $1,151 | $412,577 | 4 | Sony Pictures Releasing | false | false |
| 30 | - | Pierrepoint: The Last Hangman | $28,760 | - | 18 | - | $1,597 | $250,647 | 3 | Lionsgate | false | false |
| 31 | - | Syriana | $26,932 | - | 23 | - | $1,170 | $6,666,014 | 8 | Warner Bros. | false | false |
| 32 | 17 | Firewall | $26,565 | -72.7% | 29 | -49 | $916 | $2,150,987 | 4 | Warner Bros. | false | false |
| 33 | - | Capote | $25,478 | - | 24 | - | $1,061 | $2,588,872 | 9 | Sony Pictures Releasing | false | false |
| 34 | - | Deep Sea | $25,021 | - | 1 | - | $25,021 | $359,250 | 8 | IMAX | false | false |
| 35 | - | Ballets Russes | $23,220 | - | 3 | - | $7,740 | $23,348 | 1 | Revolver Entertainment | true | false |
| 36 | - | U-Carmen eKhayelitsha | $21,796 | - | 9 | - | $2,421 | $21,796 | 1 | Tartan | true | false |
| 37 | - | Glastonbury | $19,187 | - | 18 | - | $1,065 | $101,826 | 2 | Pathé | false | false |
| 38 | - | Tsotsi | $18,728 | - | 15 | - | $1,248 | $1,282,069 | 6 | Momentum Pictures | false | false |
| 39 | 19 | Basic Instinct 2 | $17,719 | -78.8% | 28 | -56 | $632 | $2,050,960 | 4 | Entertainment Film Distributors | false | false |
| 40 | - | Hell | $17,188 | - | 7 | - | $2,455 | $17,188 | 1 | Momentum Pictures | true | false |
| 41 | - | Good Night, and Good Luck. | $16,037 | - | 13 | - | $1,233 | $4,094,048 | 10 | Redbus Film Distribution | false | false |
| 42 | - | March of the Penguins | $15,526 | - | 41 | - | $378 | $5,490,891 | 20 | Warner Bros. | false | false |
| 43 | - | The Little Polar Bear 2: The Mysterious Island | $12,885 | - | 71 | - | $181 | $905,535 | 11 | Warner Bros. | false | false |
| 44 | - | Caché | $12,372 | - | 9 | - | $1,374 | $2,470,848 | 13 | Artificial Eye | false | false |
| 45 | - | Shooting Dogs 2006 Re-release | $12,049 | - | 14 | - | $860 | $211,149 | 4 | - | false | false |
| 46 | - | The Proposition | $10,454 | - | 10 | - | $1,045 | $1,157,037 | 7 | Tartan | false | false |
| 47 | 15 | The Dark | $10,266 | -91.3% | 40 | -140 | $256 | $1,071,712 | 3 | Momentum Pictures | false | false |
| 48 | - | Shaadi Se Pehle | $8,676 | - | 8 | - | $1,084 | $219,998 | 3 | - | false | false |
| 49 | - | Côte d'Azur | $6,969 | - | 4 | - | $1,742 | $35,508 | 2 | Peccadillo Pictures | false | false |
| 50 | - | Brokeback Mountain | $6,556 | - | 7 | - | $936 | $17,957,778 | 16 | Entertainment Film Distributors | false | false |
