| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Ice Age: The Meltdown | $6,398,332 | -62.4% | 503 | +1 | $12,720 | $34,581,198 | 2 | 20th Century Fox International | false | false |
| 2 | - | Scary Movie 4 | $2,897,578 | - | 385 | - | $7,526 | $3,463,055 | 1 | Buena Vista International | true | false |
| 3 | 4 | Inside Man | $1,134,155 | -17.8% | 321 | -12 | $3,533 | $11,289,007 | 4 | United International Pictures | false | false |
| 4 | - | Take the Lead | $1,102,406 | - | 301 | - | $3,662 | $1,102,406 | 2 | Entertainment Film Distributors | false | false |
| 5 | 2 | She's the Man | $1,063,811 | -38.6% | 306 | +1 | $3,476 | $4,024,447 | 2 | Entertainment Film Distributors | false | false |
| 6 | - | An American Haunting | $960,045 | - | 269 | - | $3,568 | $960,045 | 1 | Lionsgate | true | false |
| 7 | 3 | Alien Autopsy | $559,702 | -59.6% | 400 | -17 | $1,399 | $3,054,573 | 2 | Warner Bros. | false | false |
| 8 | 5 | Failure to Launch | $367,006 | -54.4% | 279 | -74 | $1,315 | $4,711,752 | 3 | United International Pictures | false | false |
| 9 | 7 | The Shaggy Dog | $340,170 | -29.9% | 430 | +12 | $791 | $3,632,030 | 3 | Buena Vista International | false | false |
| 10 | - | Humko Deewana Kar Gaye | $310,178 | - | 38 | - | $8,162 | $310,178 | 1 | UTV Motion Pictures | true | false |
| 11 | 6 | Hostel | $279,921 | -59.1% | 217 | -57 | $1,289 | $7,062,768 | 4 | Sony Pictures Releasing | false | false |
| 12 | 9 | The Pink Panther | $241,094 | -45.5% | 272 | -77 | $886 | $10,199,700 | 5 | 20th Century Fox International | false | false |
| 13 | 12 | Yours, Mine & Ours | $161,036 | -46.6% | 240 | -25 | $670 | $1,875,660 | 3 | Sony Pictures Releasing | false | false |
| 14 | 15 | The Squid and the Whale | $123,121 | -0.7% | 18 | +1 | $6,840 | $355,598 | 2 | Sony Pictures Releasing | false | false |
| 15 | 8 | The Dark | $117,385 | -74.6% | 180 | -11 | $652 | $948,766 | 2 | Momentum Pictures | false | false |
| 16 | - | V for Vendetta | $97,794 | - | 39 | - | $2,507 | $6,128,845 | - | Warner Bros. | - | false |
| 17 | 11 | Firewall | $97,346 | -74.4% | 78 | -187 | $1,248 | $2,045,956 | 3 | Warner Bros. | false | false |
| 18 | 16 | Transamerica | $90,459 | -22.7% | 33 | -5 | $2,741 | $1,019,350 | 4 | Pathé | false | false |
| 19 | 10 | Basic Instinct 2 | $83,551 | -78.1% | 84 | -186 | $994 | $1,980,152 | 3 | Entertainment Film Distributors | false | false |
| 20 | 17 | The Three Burials of Melquiades Estrada | $72,036 | -17.1% | 28 | -1 | $2,572 | $478,249 | 3 | Optimum Releasing | false | false |
