| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Inside Man | $1,940,340 | -38.3% | 356 | +1 | $5,450 | $6,600,089 | 2 | United International Pictures | false | false |
| 2 | - | Failure to Launch | $1,880,936 | - | 352 | - | $5,343 | $1,880,936 | 1 | United International Pictures | true | false |
| 3 | - | The Shaggy Dog | $1,443,894 | - | 417 | - | $3,462 | $1,443,894 | 1 | Buena Vista International | true | false |
| 4 | 2 | Hostel | $1,322,864 | -37.5% | 303 | -1 | $4,365 | $4,766,668 | 2 | Sony Pictures Releasing | false | false |
| 5 | 3 | The Pink Panther | $1,028,624 | -51.4% | 401 | -5 | $2,565 | $8,016,396 | 3 | 20th Century Fox International | false | false |
| 6 | - | Basic Instinct 2 | $845,981 | - | 290 | - | $2,917 | $845,981 | 1 | Entertainment Film Distributors | true | false |
| 7 | - | Firewall | $809,241 | - | 281 | - | $2,879 | $809,241 | 1 | Warner Bros. | true | false |
| 8 | 5 | The Ringer | $657,714 | -32.6% | 256 | -5 | $2,569 | $2,245,347 | 2 | 20th Century Fox International | false | false |
| 9 | - | Yours, Mine & Ours | $574,370 | - | 252 | - | $2,279 | $574,370 | 1 | Sony Pictures Releasing | true | false |
| 10 | - | V for Vendetta | $502,943 | - | 277 | - | $1,815 | $5,326,285 | - | Warner Bros. | - | false |
| 11 | 6 | The Hills Have Eyes | $190,575 | -62.6% | 167 | -121 | $1,141 | $6,004,938 | 4 | 20th Century Fox International | false | false |
| 12 | 8 | Walk the Line | $179,250 | -56% | 140 | -95 | $1,280 | $16,914,179 | 9 | 20th Century Fox International | false | false |
| 13 | 11 | Transamerica | $176,083 | -26.7% | 42 | - | $4,192 | $583,189 | 2 | Pathé | false | false |
| 14 | 7 | Syriana | $154,422 | -64.1% | 115 | -98 | $1,342 | $6,168,524 | 5 | Warner Bros. | false | false |
| 15 | - | The Three Burials of Melquiades Estrada | $143,453 | - | 29 | - | $4,946 | $143,453 | 1 | Optimum Releasing | true | false |
| 16 | - | The White Countess | $121,612 | - | 52 | - | $2,338 | $121,612 | 1 | Sony Pictures Releasing | true | false |
| 17 | 13 | Tsotsi | $95,618 | -57.9% | 69 | -18 | $1,385 | $1,017,917 | 3 | Momentum Pictures | false | false |
| 18 | 10 | Chicken Little | $76,991 | -74.4% | 298 | -109 | $258 | $23,543,809 | 8 | Buena Vista International | false | false |
| 19 | - | Shooting Dogs 2006 Re-release | $61,668 | - | 20 | - | $3,083 | $61,668 | 1 | - | true | false |
| 20 | 16 | Romance & Cigarettes | $51,756 | -57% | 27 | -2 | $1,916 | $230,809 | 2 | Icon Film Distribution | false | false |
