| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | The 40-Year-Old Virgin | $1,608,724 | - | 243 | - | $6,620 | $1,651,662 | 1 | United International Pictures | true | false |
| 2 | 1 | Cinderella Man | $764,727 | -26.9% | 294 | +1 | $2,601 | $2,487,050 | 2 | Buena Vista International | false | false |
| 3 | 2 | Wallace & Gromit: The Curse of the Were-Rabbit | $738,505 | -26.3% | 264 | -26 | $2,797 | $6,873,337 | 4 | United International Pictures | false | false |
| 4 | - | Must Love Dogs | $734,627 | - | 178 | - | $4,127 | $734,627 | 1 | Warner Bros. | true | false |
| 5 | 3 | Charlie and the Chocolate Factory | $571,035 | -40.4% | 273 | -77 | $2,091 | $17,905,821 | 6 | Roadshow Films | false | false |
| 6 | 8 | The Adventures of Sharkboy and Lavagirl 3-D | $567,431 | -18.4% | 204 | -13 | $2,781 | $3,889,107 | 5 | Sony Pictures Releasing | false | false |
| 7 | 7 | Sky High | $553,132 | -22.5% | 222 | -26 | $2,491 | $4,386,477 | 5 | Buena Vista International | false | false |
| 8 | 4 | The Dukes of Hazzard | $468,740 | -48.8% | 236 | -11 | $1,986 | $7,007,866 | 4 | Roadshow Films | false | false |
| 9 | 6 | Serenity | $419,236 | -47.7% | 117 | -55 | $3,583 | $1,593,984 | 2 | United International Pictures | false | false |
| 10 | 5 | Deuce Bigalow: European Gigolo | $338,839 | -58.8% | 202 | -25 | $1,677 | $3,632,908 | 3 | Sony Pictures Releasing | false | false |
| 11 | - | The Proposition | $323,451 | - | 63 | - | $5,134 | $323,451 | 1 | Sony Pictures Releasing | true | false |
| 12 | - | In Her Shoes | $306,566 | - | 176 | - | $1,741 | $306,566 | - | 20th Century Fox International | - | false |
| 13 | 9 | Transporter 2 | $248,041 | -53.7% | 134 | +1 | $1,851 | $1,016,170 | 2 | 20th Century Fox International | false | false |
| 14 | 10 | Little Fish | $178,014 | -26.4% | 61 | +3 | $2,918 | $1,878,909 | 5 | Icon Film Distribution | false | false |
| 15 | 13 | Howl's Moving Castle | $70,407 | -21% | 34 | - | $2,070 | $395,354 | 3 | Sony Pictures Releasing | false | false |
| 16 | 14 | Mad Hot Ballroom | $66,514 | -20.2% | 33 | - | $2,015 | $192,773 | 2 | Icon Film Distribution | false | false |
| 17 | 11 | The Perfect Man | $62,164 | -66.2% | 73 | -48 | $851 | $1,308,531 | 4 | United International Pictures | false | false |
| 18 | 15 | Look Both Ways | $53,028 | -33% | 39 | -5 | $1,359 | $1,646,789 | 8 | Dendy Films | false | false |
| 19 | 17 | Wild Safari - A South African Adventure | $51,310 | -22.4% | 2 | - | $25,655 | $695,520 | 17 | IMAX | false | false |
| 20 | 12 | Wedding Crashers | $45,248 | -66.8% | 47 | -54 | $962 | $12,533,496 | 9 | Roadshow Films | false | false |
