| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Madagascar | $632,524 | - | 219 | - | $2,888 | $796,926 | 1 | United International Pictures | true | false |
| 2 | - | Batman Begins | $294,732 | - | 88 | - | $3,349 | $294,732 | 1 | Warner Bros. | true | false |
| 3 | 1 | Star Wars: Episode III - Revenge of the Sith | $143,381 | -58.2% | 112 | -3 | $1,280 | $4,173,505 | 5 | 20th Century Fox International | false | false |
| 4 | 2 | Sin City | $94,612 | -57.6% | 83 | - | $1,139 | $821,767 | 3 | RCV Film Distribution | false | false |
| 5 | 4 | Guess Who | $78,906 | -48.1% | 34 | - | $2,320 | $308,355 | 2 | 20th Century Fox International | false | false |
| 6 | 3 | A Lot Like Love | $65,248 | -58.5% | 46 | +1 | $1,418 | $566,768 | 3 | Buena Vista International | false | false |
| 7 | 5 | Hostage | $38,386 | -64% | 57 | -6 | $673 | $571,682 | 4 | Independent Films | false | false |
| 8 | 9 | Saw | $33,534 | -48.4% | 21 | - | $1,596 | $135,972 | 2 | Inspire Pictures | false | false |
| 9 | 6 | Kingdom of Heaven | $28,394 | -73% | 58 | -33 | $489 | $2,781,448 | 7 | 20th Century Fox International | false | false |
| 10 | 7 | House of Wax | $22,581 | -67% | 30 | -9 | $752 | $392,164 | 4 | Warner Bros. | false | false |
| 11 | 8 | The Pacifier | $15,512 | -76.5% | 60 | -7 | $258 | $2,135,306 | 8 | Buena Vista International | false | false |
| 12 | - | Kinsey | $8,501 | - | 15 | - | $566 | $12,460 | 1 | Paradiso Entertainment | true | false |
| 13 | 16 | Your Next Life 2005 Re-release | $6,772 | -42.8% | 8 | - | $846 | $24,109 | 2 | Cinemien | false | false |
| 14 | 13 | The Interpreter | $6,614 | -68.8% | 12 | -14 | $551 | $1,401,131 | 10 | United International Pictures | false | false |
| 15 | 10 | The Wedding Date | $6,373 | -82.7% | 24 | -26 | $265 | $609,365 | 6 | N/A | false | false |
| 16 | 14 | A Love Song for Bobby Long | $5,938 | -55.9% | 18 | -2 | $329 | $76,196 | 3 | Moonlight Films | false | false |
| 17 | 15 | The Consequences of Love | $5,881 | -52.9% | 11 | -1 | $534 | $127,881 | 6 | Cinemien | false | false |
| 18 | 11 | Pooh's Heffalump Movie | $5,051 | -85.4% | 83 | -3 | $60 | $634,095 | 8 | Buena Vista International | false | false |
| 19 | 17 | What the #$*! Do We (K)now!? 2005 Re-release | $4,008 | -61% | 1 | -7 | $4,008 | $109,725 | 6 | Cinemien | false | false |
| 20 | 19 | The Assassination of Richard Nixon | $3,885 | -54% | 5 | -7 | $777 | $116,993 | 6 | Independent Films | false | false |
