| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Teenage Mutant Ninja Turtles II: The Secret of the Ooze | $20,030,473 | - | 2,868 | - | $6,984 | $20,030,473 | 1 | New Line Cinema | true | false |
| 2 | 1 | The Silence of the Lambs | $6,687,991 | -12.6% | 1,608 | +8 | $4,159 | $78,258,485 | 6 | Orion Pictures | false | false |
| 3 | 2 | New Jack City | $4,447,635 | -23.8% | 905 | +18 | $4,914 | $22,255,826 | 3 | Warner Bros. | false | false |
| 4 | 4 | Class Action | $4,273,745 | +1.6% | 1,108 | +330 | $3,857 | $9,817,664 | 2 | Twentieth Century Fox | false | false |
| 5 | 3 | Sleeping with the Enemy | $4,004,366 | -15% | 1,517 | -28 | $2,639 | $73,934,952 | 7 | Twentieth Century Fox | false | false |
| 6 | 8 | Dances with Wolves | $3,750,142 | +33.1% | 1,538 | -7 | $2,438 | $136,311,785 | 20 | Orion Pictures | false | false |
| 7 | 5 | The Hard Way | $3,005,505 | -25.1% | 1,629 | +2 | $1,845 | $16,419,275 | 3 | Universal Pictures | false | false |
| 8 | 9 | Home Alone | $2,776,368 | +1.6% | 1,757 | +344 | $1,580 | $253,061,346 | 19 | Twentieth Century Fox | false | false |
| 9 | 7 | The Doors | $2,277,120 | -30.3% | 1,186 | -50 | $1,920 | $26,862,388 | 4 | TriStar Pictures | false | false |
| 10 | 6 | The Perfect Weapon | $2,235,959 | -43.2% | 1,229 | - | $1,819 | $7,337,291 | 2 | Paramount Pictures | false | false |
| 11 | 10 | Guilty by Suspicion | $1,816,495 | -20.3% | 817 | - | $2,223 | $4,957,475 | 2 | Warner Bros. | false | false |
| 12 | 11 | If Looks Could Kill | $1,428,196 | -36.4% | 838 | - | $1,704 | $4,272,386 | 2 | Warner Bros. | false | false |
| 13 | - | The Long Walk Home | $1,038,960 | - | 270 | - | $3,848 | $1,307,923 | 14 | Miramax | false | false |
| 14 | - | Awakenings | $669,726 | - | 496 | - | $1,350 | $47,710,964 | 14 | Columbia Pictures | false | false |
| 15 | 14 | Kindergarten Cop | $649,620 | -19.8% | 580 | -20 | $1,120 | $83,935,593 | 14 | Universal Pictures | false | false |
| 16 | - | Goodfellas | $216,991 | - | 118 | - | $1,838 | $43,856,669 | 27 | Warner Bros. | false | false |
| 17 | - | Ghost | $200,329 | - | 205 | - | $977 | $216,445,736 | 37 | Paramount Pictures | false | false |
| 18 | - | The Godfather Part III | $108,600 | - | 75 | - | $1,448 | $65,696,793 | 13 | Paramount Pictures | false | false |
| 19 | - | Defending Your Life | $92,622 | - | 3 | - | $30,874 | $92,622 | 1 | Warner Bros. | true | false |
| 20 | - | Mister Johnson | $11,051 | - | 1 | - | $11,051 | $11,051 | 1 | Avenue Pictures Productions | true | false |
| 21 | - | Scissors | $2,368 | - | 1 | - | $2,368 | $2,368 | 1 | - | true | false |
