| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Look Who's Talking | $14,147,340 | +16.8% | 1,547 | +339 | $9,145 | $30,128,527 | 2 | TriStar Pictures | false | false |
| 2 | - | Next of Kin | $4,805,516 | - | 1,358 | - | $3,538 | $4,805,516 | 1 | Warner Bros. | true | false |
| 3 | 3 | Sea of Love | $2,951,520 | -18.3% | 1,419 | -20 | $2,080 | $46,384,395 | 6 | Universal Pictures | false | false |
| 4 | 5 | Black Rain | $2,844,545 | -17.3% | 1,615 | -145 | $1,761 | $36,113,461 | 5 | Paramount Pictures | false | false |
| 5 | - | Gross Anatomy | $2,830,387 | - | 853 | - | $3,318 | $2,830,387 | 1 | Walt Disney Studios Motion Pictures | true | false |
| 6 | 2 | Halloween 5: The Revenge of Michael Myers | $2,792,611 | -45.2% | 1,495 | +12 | $1,867 | $9,125,564 | 2 | - | false | false |
| 7 | 6 | The Fabulous Baker Boys | $2,778,848 | -16.1% | 860 | +2 | $3,231 | $7,292,181 | 2 | Twentieth Century Fox | false | false |
| 8 | 4 | An Innocent Man | $2,346,739 | -34.9% | 1,520 | -41 | $1,543 | $14,381,535 | 3 | Walt Disney Studios Motion Pictures | false | false |
| 9 | 7 | Parenthood | $1,508,325 | -10.7% | 1,183 | -131 | $1,275 | $89,418,930 | 12 | Universal Pictures | false | false |
| 10 | - | Fat Man and Little Boy | $1,476,994 | - | 843 | - | $1,752 | $1,476,994 | 1 | Paramount Pictures | true | false |
| 11 | 8 | Uncle Buck | $1,212,482 | -21.7% | 1,080 | -290 | $1,122 | $60,241,745 | 10 | Universal Pictures | false | false |
| 12 | 9 | When Harry Met Sally... | $1,114,289 | -9.4% | 1,064 | -56 | $1,047 | $86,689,724 | 15 | Columbia Pictures | false | false |
| 13 | 10 | Crimes and Misdemeanors | $925,463 | +1.5% | 68 | +2 | $13,609 | $2,225,118 | 2 | Orion Pictures | false | false |
| 14 | 13 | Batman | $299,580 | -26.2% | 353 | -132 | $848 | $247,932,803 | 18 | Warner Bros. | false | false |
| 15 | - | When the Whales Came | $37,030 | - | 10 | - | $3,703 | $37,030 | 1 | Twentieth Century Fox | true | false |
