| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Uncle Buck | $6,725,275 | -23.5% | 1,835 | +31 | $3,665 | $23,670,446 | 2 | Universal Pictures | false | false |
| 2 | 2 | Parenthood | $6,380,240 | -16.1% | 1,384 | +68 | $4,610 | $53,704,836 | 4 | Universal Pictures | false | false |
| 3 | 3 | The Abyss | $4,734,287 | -34.4% | 1,525 | -13 | $3,104 | $32,963,185 | 3 | Twentieth Century Fox | false | false |
| 4 | 5 | When Harry Met Sally... | $4,056,399 | -17.2% | 1,171 | +27 | $3,464 | $60,655,531 | 7 | Columbia Pictures | false | false |
| 5 | 6 | Lethal Weapon 2 | $3,335,582 | -26.1% | 1,560 | -24 | $2,138 | $125,055,875 | 8 | Warner Bros. | false | false |
| 6 | 7 | Turner & Hooch | $3,021,348 | -29.3% | 1,551 | -43 | $1,948 | $51,880,351 | 5 | Walt Disney Studios Motion Pictures | false | false |
| 7 | 4 | Casualties of War | $2,866,498 | -44.9% | 1,487 | - | $1,927 | $10,544,928 | 2 | Columbia Pictures | false | false |
| 8 | 9 | Batman | $2,597,560 | -24.5% | 1,302 | -98 | $1,995 | $233,653,196 | 10 | Warner Bros. | false | false |
| 9 | - | The Package | $1,851,673 | - | 323 | - | $5,732 | $1,851,673 | 1 | Orion Pictures | true | false |
| 10 | 11 | Honey, I Shrunk the Kids | $1,736,256 | -20.1% | 1,189 | +31 | $1,460 | $115,420,530 | 10 | Walt Disney Studios Motion Pictures | false | false |
| 11 | 8 | A Nightmare on Elm Street: The Dream Child | $1,696,495 | -52.7% | 1,114 | -732 | $1,522 | $17,650,275 | 3 | New Line Cinema | false | false |
| 12 | - | Millennium | $1,614,692 | - | 486 | - | $3,322 | $1,614,692 | 1 | Twentieth Century Fox | true | false |
| 13 | 18 | Sex, Lies, and Videotape | $1,210,540 | +51.8% | 101 | +61 | $11,985 | $3,798,540 | 4 | Miramax | false | false |
| 14 | 10 | Cheetah | $1,190,212 | -54.8% | 1,321 | +11 | $900 | $5,436,167 | 2 | Walt Disney Studios Motion Pictures | false | false |
| 15 | 13 | Lock Up | $1,093,678 | -34.3% | 829 | -203 | $1,319 | $17,120,135 | 4 | TriStar Pictures | false | false |
| 16 | 12 | Let It Ride | $986,869 | -48.7% | 1,191 | - | $828 | $3,866,707 | 2 | Paramount Pictures | false | false |
| 17 | 15 | Dead Poets Society | $963,442 | -7.8% | 671 | +38 | $1,435 | $84,547,818 | 13 | Walt Disney Studios Motion Pictures | false | false |
| 18 | 16 | Indiana Jones and the Last Crusade | $726,388 | -30% | 431 | -80 | $1,685 | $186,475,287 | 14 | Paramount Pictures | false | false |
| 19 | - | Wired | $681,054 | - | 745 | - | $914 | $681,054 | 1 | Taurus Entertainment Company | true | false |
| 20 | 17 | Ghostbusters II | $652,634 | -18.4% | 606 | -19 | $1,076 | $109,006,128 | 11 | Columbia Pictures | false | false |
| 21 | - | The Adventures of Milo and Otis | $470,084 | - | 239 | - | $1,966 | $470,084 | 1 | Columbia Pictures | true | false |
| 22 | 14 | Rude Awakening | $394,843 | -64.8% | 905 | -48 | $436 | $2,455,421 | 2 | Orion Pictures | false | false |
| 23 | - | Heart of Dixie | $367,091 | - | 359 | - | $1,022 | $367,091 | 1 | Orion Pictures | true | false |
| 24 | - | Cookie | $292,483 | - | 82 | - | $3,566 | $292,483 | 1 | Warner Bros. | true | false |
| 25 | - | Little Monsters | $253,834 | - | 179 | - | $1,418 | $253,834 | 1 | United Artists | true | false |
| 26 | - | Romero | $10,189 | - | 2 | - | $5,094 | $10,189 | 1 | Four Square | true | false |
