| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | The Fly II | $6,751,371 | - | 1,524 | - | $4,430 | $6,751,371 | 1 | Twentieth Century Fox | true | false |
| 2 | 1 | Three Fugitives | $5,096,954 | -6.9% | 1,374 | +183 | $3,709 | $20,056,453 | 3 | Walt Disney Studios Motion Pictures | false | false |
| 3 | 2 | Rain Man | $4,540,785 | -16.7% | 1,573 | - | $2,886 | $102,224,027 | 9 | Metro-Goldwyn-Mayer (MGM) | false | false |
| 4 | 4 | Beaches | $3,707,524 | -10.7% | 1,122 | +13 | $3,304 | $30,887,641 | 8 | Walt Disney Studios Motion Pictures | false | false |
| 5 | 3 | Her Alibi | $3,443,772 | -31.6% | 1,429 | - | $2,409 | $9,691,050 | 2 | Warner Bros. | false | false |
| 6 | - | Cousins | $3,039,805 | - | 535 | - | $5,681 | $3,039,805 | 1 | Paramount Pictures | true | false |
| 7 | 6 | Twins | $2,865,240 | -14.4% | 1,512 | -98 | $1,895 | $94,384,635 | 10 | Universal Pictures | false | false |
| 8 | 5 | Who's Harry Crumb? | $2,314,536 | -40.1% | 1,198 | +1 | $1,932 | $6,985,617 | 2 | TriStar Pictures | false | false |
| 9 | - | Tap | $2,217,150 | - | 585 | - | $3,790 | $2,217,150 | 1 | TriStar Pictures | true | false |
| 10 | 7 | Working Girl | $2,109,890 | -16.9% | 1,100 | -33 | $1,918 | $44,500,809 | 8 | Twentieth Century Fox | false | false |
| 11 | 11 | Dangerous Liaisons | $1,808,801 | +59.5% | 347 | +228 | $5,212 | $8,670,444 | 8 | Warner Bros. | false | false |
| 12 | 8 | Mississippi Burning | $1,725,034 | -30.3% | 1,056 | -18 | $1,633 | $20,692,406 | 10 | Orion Pictures | false | false |
| 13 | 9 | The Naked Gun: From the Files of Police Squad! | $1,352,976 | -28.7% | 1,026 | -232 | $1,318 | $72,751,389 | 11 | Paramount Pictures | false | false |
| 14 | 10 | The Accidental Tourist | $855,614 | -44.4% | 565 | -191 | $1,514 | $25,230,033 | 8 | Warner Bros. | false | false |
