| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Rain Man | $6,829,705 | -2.5% | 1,563 | +54 | $4,369 | $88,805,610 | 7 | Metro-Goldwyn-Mayer (MGM) | false | false |
| 2 | - | Three Fugitives | $6,434,717 | - | 1,153 | - | $5,580 | $6,434,717 | 1 | Walt Disney Studios Motion Pictures | true | false |
| 3 | 3 | Beaches | $4,939,903 | +3.1% | 1,097 | +288 | $4,503 | $20,138,468 | 6 | Walt Disney Studios Motion Pictures | false | false |
| 4 | 2 | Twins | $4,802,805 | -0.4% | 1,659 | +19 | $2,895 | $86,518,865 | 8 | Universal Pictures | false | false |
| 5 | 7 | Mississippi Burning | $3,545,305 | +33.7% | 1,058 | +490 | $3,350 | $14,726,112 | 8 | Orion Pictures | false | false |
| 6 | 5 | Working Girl | $3,004,374 | -2.4% | 1,149 | +1 | $2,614 | $38,232,402 | 6 | Twentieth Century Fox | false | false |
| 7 | 6 | The Naked Gun: From the Files of Police Squad! | $2,868,339 | -5.4% | 1,501 | -186 | $1,910 | $68,367,615 | 9 | Paramount Pictures | false | false |
| 8 | 4 | The Accidental Tourist | $2,561,533 | -22.7% | 926 | -28 | $2,766 | $21,844,098 | 6 | Warner Bros. | false | false |
| 9 | - | Physical Evidence | $1,777,358 | - | 691 | - | $2,572 | $1,777,358 | 1 | Columbia Pictures | true | false |
| 10 | 8 | Dirty Rotten Scoundrels | $1,637,651 | -22.3% | 1,313 | -202 | $1,247 | $36,435,956 | 7 | Orion Pictures | false | false |
| 11 | 14 | Dangerous Liaisons | $1,300,240 | +50.4% | 119 | +45 | $10,926 | $4,900,088 | 6 | Warner Bros. | false | false |
| 12 | 10 | Oliver & Company | $1,054,889 | -23.1% | 1,316 | -138 | $801 | $49,424,284 | 11 | Walt Disney Studios Motion Pictures | false | false |
| 13 | - | Parents | $277,952 | - | 94 | - | $2,956 | $277,952 | 1 | Vestron Pictures | true | false |
| 14 | - | Cohen and Tate | $45,586 | - | 75 | - | $607 | $45,586 | 1 | Hemdale | true | false |
| 15 | - | Manifesto | $9,838 | - | 1 | - | $9,838 | $9,838 | 1 | Cannon Film Distributors | true | false |
