| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | The Fly | $4,725,970 | -32.6% | 1,201 | +6 | $3,935 | $15,681,173 | 2 | Twentieth Century Fox | false | false |
| 2 | 19 | Stand by Me | $3,812,093 | +1,398.3% | 745 | +729 | $5,116 | $4,684,502 | 3 | Columbia Pictures | false | false |
| 3 | 3 | Aliens | $3,371,670 | -21.6% | 1,280 | -22 | $2,634 | $60,977,693 | 6 | Twentieth Century Fox | false | false |
| 4 | 6 | Top Gun | $3,326,355 | +6.7% | 1,201 | -15 | $2,769 | $124,440,927 | 15 | Paramount Pictures | false | false |
| 5 | - | The Texas Chainsaw Massacre 2 | $2,822,439 | - | 1,474 | - | $1,914 | $2,822,439 | 1 | Cannon Film Distributors | true | false |
| 6 | 4 | The Karate Kid Part II | $2,807,701 | -16% | 1,549 | -21 | $1,812 | $93,653,926 | 10 | Columbia Pictures | false | false |
| 7 | 2 | Armed and Dangerous | $2,606,009 | -40.1% | 1,557 | +5 | $1,673 | $9,137,326 | 2 | Columbia Pictures | false | false |
| 8 | 5 | Nothing in Common | $2,575,832 | -19.9% | 951 | +108 | $2,708 | $17,319,959 | 4 | TriStar Pictures | false | false |
| 9 | - | Extremities | $2,429,075 | - | 605 | - | $4,015 | $2,429,075 | 1 | Atlantic Releasing Corporation | true | false |
| 10 | 7 | Ruthless People | $2,128,889 | -13.4% | 954 | -65 | $2,231 | $55,373,046 | 9 | Walt Disney Studios Motion Pictures | false | false |
| 11 | 8 | Manhunter | $1,281,768 | -41.9% | 767 | -12 | $1,671 | $4,671,253 | 2 | De Laurentiis Entertainment Group (DEG) | false | false |
| 12 | 12 | About Last Night | $1,228,558 | -22.6% | 787 | -93 | $1,561 | $30,442,282 | 8 | TriStar Pictures | false | false |
| 13 | 14 | Back to School | $1,202,918 | -19.6% | 779 | -131 | $1,544 | $77,905,620 | 11 | Orion Pictures | false | false |
| 14 | 9 | One Crazy Summer | $1,128,787 | -44% | 792 | -192 | $1,425 | $10,040,808 | 3 | Warner Bros. | false | false |
| 15 | 15 | Ferris Bueller's Day Off | $1,118,404 | -9% | 685 | -93 | $1,632 | $58,778,922 | 11 | Paramount Pictures | false | false |
| 16 | 13 | Flight of the Navigator | $1,107,998 | -27.8% | 916 | -45 | $1,209 | $13,776,429 | 4 | Walt Disney Studios Motion Pictures | false | false |
| 17 | 10 | Heartburn | $1,037,182 | -36.8% | 699 | -103 | $1,483 | $20,933,069 | 5 | Paramount Pictures | false | false |
| 18 | 18 | The Transformers: The Movie | $505,229 | -45.4% | 846 | -144 | $597 | $4,837,143 | 3 | De Laurentiis Entertainment Group (DEG) | false | false |
| 19 | 17 | Howard the Duck | $350,745 | -65.9% | 349 | -565 | $1,005 | $14,420,333 | 4 | Universal Pictures | false | false |
| 20 | - | Night of the Creeps | $220,800 | - | 70 | - | $3,154 | $220,800 | 1 | TriStar Pictures | true | false |
| 21 | - | Touch and Go | $126,939 | - | 51 | - | $2,489 | $126,939 | 1 | TriStar Pictures | true | false |
