| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Avatar | - | - | - | $331,949,045 | 3,461 | $749,766,139 | Dec 18 | Twentieth Century Fox | false |
| 2 | Valentine's Day | - | - | - | $102,149,760 | 3,665 | $110,485,654 | Feb 12 | Warner Bros. | false |
| 3 | The Book of Eli | - | - | - | $92,879,734 | 3,111 | $94,835,059 | Jan 15 | Warner Bros. | false |
| 4 | Shutter Island | - | - | - | $82,524,594 | 3,356 | $128,012,934 | Feb 19 | Paramount Pictures | false |
| 5 | Dear John | - | - | - | $73,844,007 | 3,062 | $80,014,842 | Feb 5 | Screen Gems | false |
| 6 | Percy Jackson & the Olympians: The Lightning Thief | - | - | - | $72,933,126 | 3,396 | $88,768,303 | Feb 12 | Twentieth Century Fox | false |
| 7 | The Wolfman | - | - | - | $58,809,485 | 3,223 | $61,979,680 | Feb 12 | Universal Pictures | false |
| 8 | Sherlock Holmes | - | - | - | $58,048,304 | 3,626 | $209,028,679 | Dec 25 | Warner Bros. | false |
| 9 | Alvin and the Chipmunks: The Squeakquel | - | - | - | $54,937,965 | 3,747 | $219,614,612 | Dec 23 | Twentieth Century Fox | false |
| 10 | Tooth Fairy | - | - | - | $54,555,647 | 3,345 | $60,022,256 | Jan 22 | Twentieth Century Fox | false |
| 11 | It's Complicated | - | - | - | $46,367,250 | 2,955 | $112,735,375 | Dec 25 | Universal Pictures | false |
| 12 | The Lovely Bones | - | - | - | $43,238,345 | 2,638 | $44,114,232 | Dec 11 | DreamWorks | false |
| 13 | Edge of Darkness | - | - | - | $42,552,257 | 3,066 | $43,313,890 | Jan 29 | Warner Bros. | false |
| 14 | Legion | - | - | - | $39,735,321 | 2,476 | $40,168,080 | Jan 22 | Screen Gems | false |
| 15 | The Blind Side | - | - | - | $37,762,952 | 3,407 | $255,959,475 | Nov 20 | Warner Bros. | false |
| 16 | Up in the Air | - | - | - | $34,762,017 | 2,218 | $83,823,381 | Dec 4 | Paramount Pictures | false |
| 17 | When in Rome | - | - | - | $31,145,051 | 2,456 | $32,680,633 | Jan 29 | Walt Disney Studios Motion Pictures | false |
| 18 | Daybreakers | - | - | - | $30,101,577 | 2,523 | $30,101,577 | Jan 8 | Lionsgate | false |
| 19 | Leap Year | - | - | - | $25,918,920 | 2,512 | $25,918,920 | Jan 8 | Universal Pictures | false |
| 20 | Crazy Heart | - | - | - | $25,434,790 | 1,361 | $39,464,306 | Dec 16 | Fox Searchlight Pictures | false |
| 21 | The Spy Next Door | - | - | - | $24,307,086 | 2,924 | $24,307,086 | Jan 15 | Lionsgate | false |
| 22 | From Paris with Love | - | - | - | $23,712,059 | 2,722 | $24,077,427 | Feb 5 | Lionsgate | false |
| 23 | Cop Out | - | - | - | $23,215,299 | 3,150 | $44,875,481 | Feb 26 | Warner Bros. | false |
| 24 | The Crazies | - | - | - | $20,393,313 | 2,479 | $39,123,589 | Feb 26 | Overture Films | false |
| 25 | The Princess and the Frog | - | - | - | $15,500,047 | 3,475 | $104,400,899 | Nov 25 | Walt Disney Studios Motion Pictures | false |
| 26 | Youth in Revolt | - | - | - | $15,211,044 | 1,873 | $15,281,286 | Jan 8 | - | false |
| 27 | Extraordinary Measures | - | - | - | $12,068,313 | 2,549 | $12,068,313 | Jan 22 | CBS Films | false |
| 28 | The Twilight Saga: New Moon | - | - | - | $7,074,328 | 4,124 | $296,623,634 | Nov 20 | Summit Entertainment | false |
| 29 | The Young Victoria | - | - | - | $6,879,531 | 476 | $11,001,272 | Dec 18 | Apparition | false |
| 30 | The Imaginarium of Doctor Parnassus | - | - | - | $6,239,695 | 607 | $7,689,607 | Dec 25 | Sony Pictures Classics | false |
| 31 | A Single Man | - | - | - | $6,211,652 | 354 | $9,176,000 | Dec 11 | The Weinstein Company | false |
| 32 | Invictus | - | - | - | $5,405,504 | 2,170 | $37,491,364 | Dec 11 | Warner Bros. | false |
| 33 | Nine | - | - | - | $4,432,342 | 1,412 | $19,676,965 | Dec 18 | The Weinstein Company | false |
| 34 | The Last Station | - | - | - | $3,810,121 | 354 | $6,617,867 | Jan 15 | Sony Pictures Classics | false |
| 35 | My Name Is Khan | - | - | - | $3,704,926 | 125 | $4,018,771 | Feb 12 | Fox Searchlight Pictures | false |
| 36 | An Education | - | - | - | $3,675,858 | 763 | $12,574,914 | Oct 9 | Sony Pictures Classics | false |
| 37 | To Save a Life | - | - | - | $3,510,259 | 441 | $3,777,210 | Jan 22 | The Samuel Goldwyn Company | false |
| 38 | Precious | - | - | - | $3,367,246 | 1,003 | $47,566,524 | Nov 6 | Lionsgate | false |
| 39 | Did You Hear About the Morgans? | - | - | - | $2,779,836 | 2,718 | $29,580,087 | Dec 18 | Sony Pictures Releasing | false |
| 40 | Broken Embraces | - | - | - | $2,445,056 | 202 | $5,014,305 | Nov 20 | Sony Pictures Classics | false |
| 41 | Planet 51 | - | - | - | $2,385,468 | 3,035 | $42,194,060 | Nov 20 | Sony Pictures Releasing | false |
| 42 | 2012 | - | - | - | $2,374,381 | 3,444 | $166,112,167 | Nov 13 | Sony Pictures Releasing | false |
| 43 | The Hurt Locker | - | - | - | $1,589,895 | 535 | $17,017,811 | Jun 26 | Summit Entertainment | false |
| 44 | Fantastic Mr. Fox | - | - | - | $1,560,142 | 2,304 | $21,002,919 | Nov 13 | Twentieth Century Fox | false |
| 45 | 3 Idiots | - | - | - | $1,523,193 | 156 | $6,532,874 | Dec 23 | Reliance Big Pictures | false |
| 46 | The White Ribbon | - | - | - | $1,449,854 | 106 | $2,222,862 | Dec 30 | Sony Pictures Classics | false |
| 47 | Old Dogs | - | - | - | $1,407,167 | 3,425 | $49,492,060 | Nov 25 | Walt Disney Studios Motion Pictures | false |
| 48 | The Ghost Writer | - | - | - | $1,312,859 | 819 | $15,541,549 | Feb 19 | Summit Entertainment | false |
| 49 | Under the Sea 3D | - | - | - | $1,229,531 | 108 | $36,262,926 | Feb 13 | Warner Bros. | false |
| 50 | The Road | - | - | - | $989,064 | 396 | $8,117,000 | Nov 25 | - | false |
| 51 | The Oscar Nominated Short Films 2010: Live Action | - | - | - | $710,537 | 95 | $1,018,169 | Feb 19 | Shorts International | false |
| 52 | Brothers | - | - | - | $709,997 | 2,088 | $28,544,157 | Dec 4 | Lionsgate | false |
| 53 | Space Station 3D | - | - | - | $650,537 | 64 | $93,383,953 | Apr 19 | IMAX | false |
| 54 | Couples Retreat | - | - | - | $621,035 | 3,074 | $109,204,945 | Oct 9 | Universal Pictures | false |
| 55 | Magnificent Desolation: Walking on the Moon | - | - | - | $605,543 | 82 | $34,137,524 | Sep 23 | IMAX | false |
| 56 | Where the Wild Things Are | - | - | - | $578,549 | 3,735 | $77,233,467 | Oct 16 | Warner Bros. | false |
| 57 | Ninja Assassin | - | - | - | $566,444 | 2,503 | $38,122,883 | Nov 25 | Warner Bros. | false |
| 58 | Veer | - | - | - | $527,193 | 92 | $527,193 | Jan 22 | Eros Worldwide | false |
| 59 | Cloudy with a Chance of Meatballs | - | - | - | $523,435 | 3,119 | $124,870,275 | Sep 18 | Sony Pictures Releasing | false |
| 60 | Preacher's Kid | - | - | - | $473,727 | 109 | $515,065 | Jan 29 | 8x Entertainment | false |
| 61 | The Men Who Stare at Goats | - | - | - | $390,645 | 2,453 | $32,428,195 | Nov 6 | Overture Films | false |
| 62 | Law Abiding Citizen | - | - | - | $361,473 | 2,890 | $73,357,727 | Oct 16 | Overture Films | false |
| 63 | The Messenger | - | - | - | $310,957 | 50 | $1,109,660 | Nov 13 | Oscilloscope | false |
| 64 | A Christmas Carol | - | - | - | $293,301 | 3,683 | $137,855,863 | Nov 6 | Walt Disney Studios Motion Pictures | false |
| 65 | North Face | - | - | - | $281,999 | 36 | $711,421 | Jan 29 | Music Box Films | false |
| 66 | Ajami | - | - | - | $275,847 | 23 | $622,403 | Feb 3 | Kino International | false |
| 67 | Fish Tank | - | - | - | $275,823 | 15 | $374,675 | Jan 15 | IFC Films | false |
| 68 | A Prophet | - | - | - | $252,627 | 83 | $2,087,720 | Feb 26 | Sony Pictures Classics | false |
| 69 | The Boondock Saints II: All Saints Day | - | - | - | $251,512 | 524 | $10,273,188 | Oct 30 | Apparition | false |
| 70 | Bad Lieutenant: Port of Call New Orleans | - | - | - | $247,574 | 96 | $1,702,112 | Nov 20 | First Look International | false |
| 71 | Creation | - | - | - | $241,519 | 12 | $341,323 | Jan 22 | Newmarket Films | false |
| 72 | Frozen | - | - | - | $232,264 | 106 | $246,176 | Feb 5 | Anchor Bay Films | false |
| 73 | Sea Monsters: A Prehistoric Adventure | - | - | - | $222,493 | 252 | $23,746,066 | Oct 5 | National Geographic Entertainment | false |
| 74 | Karthik Calling Karthik | - | - | - | $208,242 | 70 | $286,409 | Feb 26 | Eros Worldwide | false |
| 75 | Me and Orson Welles | - | - | - | $204,488 | 134 | $1,190,003 | Nov 25 | Freestyle Releasing | false |
| 76 | The Most Dangerous Man in America: Daniel Ellsberg and the Pentagon Papers | - | - | - | $182,548 | 12 | $453,993 | Jan 29 | First Run | false |
| 77 | Chance Pe Dance | - | - | - | $168,643 | 68 | $168,643 | Jan 15 | UTV Motion Pictures | false |
| 78 | Deep Sea | - | - | - | $148,174 | 47 | $46,412,757 | Mar 3 | Warner Bros. | false |
| 79 | That Evening Sun | - | - | - | $138,698 | 10 | $281,350 | Nov 6 | Freestyle Releasing | false |
| 80 | Dolphins and Whales 3D: Tribes of the Ocean | - | - | - | $125,411 | 42 | $7,714,996 | Feb 15 | 3D Entertainment | false |
| 81 | La Danse: The Paris Opera Ballet | - | - | - | $112,532 | 25 | $567,493 | Nov 4 | Zipporah Films | false |
| 82 | Blood Done Sign My Name | - | - | - | $109,383 | 95 | $109,383 | Feb 19 | Paladin | false |
| 83 | The Secrets of Jonathan Sperry | - | - | - | $106,758 | 135 | $1,355,079 | Sep 18 | Five & Two Pictures | false |
| 84 | Saint John of Las Vegas | - | - | - | $102,645 | 14 | $102,645 | Jan 29 | IndieVest Pictures | false |
| 85 | The Girl on the Train | - | - | - | $102,071 | 10 | $208,023 | Jan 22 | Strand Releasing | false |
| 86 | Coco Before Chanel | - | - | - | $101,421 | 307 | $6,113,834 | Sep 25 | Sony Pictures Classics | false |
| 87 | Armored | - | - | - | $99,082 | 1,919 | $15,988,876 | Dec 4 | Screen Gems | false |
| 88 | Formosa Betrayed | - | - | - | $93,881 | 16 | $225,341 | Feb 26 | Screen Media Films | false |
| 89 | Crazy on the Outside | - | - | - | $88,335 | 75 | $88,335 | Jan 8 | Freestyle Releasing | false |
| 90 | A Town Called Panic | - | - | - | $88,160 | 10 | $165,509 | Dec 16 | Zeitgeist Films | false |
| 91 | Terribly Happy | - | - | - | $83,992 | 9 | $170,943 | Feb 5 | Oscilloscope | false |
| 92 | Astro Boy | - | - | - | $79,726 | 3,020 | $19,551,067 | Oct 23 | Summit Entertainment | false |
| 93 | The Good Guy | - | - | - | $76,749 | 9 | $100,688 | Feb 19 | Roadside Attractions | false |
| 94 | House | - | - | - | $73,651 | 7 | $209,765 | Jan 15 | Janus Films | false |
| 95 | Red Riding: The Year of Our Lord 1974 | - | - | - | $72,706 | 9 | $151,644 | Feb 5 | IFC Films | false |
| 96 | Red Cliff | - | - | - | $70,813 | 42 | $627,047 | Nov 18 | Magnolia Pictures | false |
| 97 | The Private Lives of Pippa Lee | - | - | - | $70,771 | 26 | $337,356 | Nov 27 | Screen Media Films | false |
| 98 | The Maid | - | - | - | $63,920 | 19 | $576,608 | Oct 16 | Elephant Eye Films | false |
| 99 | Until the Light Takes Us | - | - | - | $54,831 | 3 | $130,441 | Dec 4 | Variance Films | false |
| 100 | The Art of the Steal | - | - | - | $53,818 | 34 | $544,890 | Feb 26 | IFC Films | false |
| 101 | The Yellow Handkerchief | - | - | - | $50,888 | 29 | $318,623 | Feb 26 | The Samuel Goldwyn Company | false |
| 102 | The Weathered Underground | - | - | - | $47,548 | 22 | $140,091 | Jan 26 | Indican Pictures | false |
| 103 | Defendor | - | - | - | $44,462 | 4 | $44,462 | Feb 19 | Darius Films | false |
| 104 | Paranormal Activity | - | - | - | $44,097 | 2,712 | $107,918,810 | Sep 25 | Paramount Pictures | false |
| 105 | Sweetgrass | - | - | - | $38,935 | 9 | $207,473 | Jan 6 | The Cinema Guild | false |
| 106 | Killing Kasztner | - | - | - | $37,722 | 5 | $112,313 | Oct 23 | Sky Island Films | false |
| 107 | Ran 2010 Re-release | - | - | - | $37,532 | 4 | $124,673 | Feb 5 | Rialto Pictures | false |
| 108 | 44 Inch Chest 2010 Re-release | - | - | - | $36,420 | 5 | $39,033 | Jan 15 | Image Entertainment | false |
| 109 | District 13: Ultimatum | - | - | - | $29,216 | 9 | $36,136 | Feb 5 | Magnolia Pictures | false |
| 110 | 35 Shots of Rum | - | - | - | $27,779 | 5 | $177,511 | Sep 16 | The Cinema Guild | false |
| 111 | The Yes Men Fix the World | - | - | - | $25,768 | 16 | $194,533 | Sep 25 | Shadow Distribution | false |
| 112 | Eyes Wide Open | - | - | - | $23,492 | 1 | $26,258 | Feb 5 | New American Vision | false |
| 113 | Seraphine | - | - | - | $22,585 | 24 | $884,613 | Jun 5 | Music Box Films | false |
| 114 | Happy Tears | - | - | - | $22,229 | 15 | $22,464 | Feb 19 | Roadside Attractions | false |
| 115 | Mystery Team | - | - | - | $21,516 | 4 | $89,442 | Aug 28 | Roadside Attractions | false |
| 116 | U2 3D | - | - | - | $21,079 | 686 | $10,363,341 | Jan 23 | National Geographic Entertainment | false |
| 117 | Videocracy | - | - | - | $20,345 | 1 | $23,720 | Feb 12 | Kino International | false |
| 118 | The Korean | - | - | - | $18,686 | 2 | $20,279 | Feb 5 | Indican Pictures | false |
| 119 | The Horse Boy | - | - | - | $18,321 | 5 | $156,612 | Sep 30 | Zeitgeist Films | false |
| 120 | Bitch Slap | - | - | - | $17,365 | 3 | $17,365 | Jan 8 | Freestyle Releasing | false |
| 121 | Amelia | - | - | - | $15,614 | 1,070 | $14,246,488 | Oct 23 | Fox Searchlight Pictures | false |
| 122 | Off and Running | - | - | - | $14,637 | 1 | $18,262 | Jan 29 | First Run | false |
| 123 | October Country | - | - | - | $14,014 | 4 | $26,185 | Feb 12 | International Film Circuit | false |
| 124 | The Wedding Song | - | - | - | $13,544 | 4 | $31,160 | Oct 9 | Strand Releasing | false |
| 125 | The End of Poverty? | - | - | - | $12,984 | 5 | $57,805 | Nov 13 | Cinema Libre Studio | false |
| 126 | The Little Traitor | - | - | - | $11,963 | 5 | $402,088 | Oct 23 | - | false |
| 127 | The Sun 2009 Re-release | - | - | - | $11,499 | 4 | $77,303 | Nov 18 | Lorber Films | false |
| 128 | Four Seasons Lodge | - | - | - | $11,229 | 3 | $58,334 | Nov 11 | First Run | false |
| 129 | Galapagos | - | - | - | $11,142 | 14 | $18,630,372 | Oct 29 | IMAX | false |
| 130 | The Beaches of Agnès | - | - | - | $10,838 | 7 | $239,711 | Jul 2 | The Cinema Guild | false |
| 131 | Good Hair | - | - | - | $10,735 | 466 | $4,157,223 | Oct 9 | Roadside Attractions | false |
| 132 | Waiting for Armageddon | - | - | - | $10,501 | 1 | $10,501 | Jan 8 | First Run | false |
| 133 | Wonderful World | - | - | - | $9,309 | 4 | $9,309 | Jan 8 | Magnolia Pictures | false |
| 134 | Shanghai Red 2010 Re-release | - | - | - | $8,659 | 3 | $30,353 | Feb 12 | Indican Pictures | false |
| 135 | The Damned United | - | - | - | $8,601 | 45 | $449,865 | Oct 9 | Sony Pictures Classics | false |
| 136 | Prodigal Sons | - | - | - | $8,141 | 11 | $73,544 | Feb 26 | First Run | false |
| 137 | The Missing Person | - | - | - | $7,874 | 3 | $17,896 | Nov 20 | Strand Releasing | false |
| 138 | Youssou Ndour: I Bring What I Love | - | - | - | $6,896 | 7 | $172,225 | Jun 12 | Shadow Distribution | false |
| 139 | Amreeka | - | - | - | $6,253 | 40 | $627,436 | Sep 4 | National Geographic Entertainment | false |
| 140 | Misconceptions | - | - | - | $5,825 | 2 | $6,892 | Jan 22 | Regent Releasing | false |
| 141 | Toe to Toe | - | - | - | $5,819 | 2 | $21,648 | Feb 26 | Strand Releasing | false |
| 142 | Under Our Skin | - | - | - | $5,676 | 6 | $98,548 | Jun 19 | Shadow Distribution | false |
| 143 | Small Change | - | - | - | $5,220 | 2 | $38,296 | Nov 24 | The Film Desk | false |
| 144 | Crude | - | - | - | $5,095 | 7 | $170,295 | Sep 9 | First Run | false |
| 145 | Beeswax | - | - | - | $4,970 | 3 | $46,590 | Aug 7 | The Cinema Guild | false |
| 146 | Mississippi Mermaid | - | - | - | $4,964 | 1 | $33,216 | Jul 10 | The Film Desk | false |
| 147 | Watercolors | - | - | - | $4,908 | 2 | $6,305 | Jan 22 | Regent Releasing | false |
| 148 | Harlan: In the Shadow of Jew Suess | - | - | - | $4,794 | 5 | $54,305 | Mar 3 | Zeitgeist Films | false |
| 149 | Brutal Beauty: Tales of the Rose City Rollers | - | - | - | $4,744 | 2 | $9,677 | Jan 8 | Cinema Purgatorio | false |
| 150 | Harmony and Me | - | - | - | $4,596 | 1 | $20,099 | Sep 18 | - | false |
| 151 | The Cove | - | - | - | $4,481 | 56 | $857,005 | Jul 31 | Roadside Attractions | false |
| 152 | Le combat dans l'île | - | - | - | $4,407 | 1 | $50,039 | Jun 12 | The Film Desk | false |
| 153 | Departures | - | - | - | $3,640 | 27 | $1,498,210 | May 29 | Regent Releasing | false |
| 154 | Cloud 9 | - | - | - | $3,506 | 8 | $91,675 | Aug 14 | Music Box Films | false |
| 155 | The Headless Woman | - | - | - | $3,014 | 3 | $100,177 | Aug 19 | Strand Releasing | false |
| 156 | Promised Lands | - | - | - | $2,899 | 1 | $4,546 | Feb 5 | The Film Desk | false |
| 157 | Bliss 2009 Re-release | - | - | - | $2,856 | 3 | $40,349 | Aug 7 | First Run | false |
| 158 | The Slammin' Salmon | - | - | - | $2,667 | 11 | $41,587 | Dec 11 | Anchor Bay Films | false |
| 159 | Dreamkiller | - | - | - | $2,462 | 3 | $15,514 | Feb 19 | Delaware Pictures | false |
| 160 | Big Fan | - | - | - | $2,396 | 15 | $234,540 | Aug 28 | First Independent Pictures | false |
| 161 | The Wild Child | - | - | - | $2,192 | 2 | $65,051 | Nov 7 | The Film Desk | false |
| 162 | The September Issue | - | - | - | $2,065 | 143 | $3,820,067 | Aug 28 | Roadside Attractions | false |
| 163 | Fashion Victim | - | - | - | $2,050 | 2 | $3,346 | Jan 22 | Regent Releasing | false |
| 164 | Falling Awake | - | - | - | $1,978 | 2 | $1,978 | Jan 29 | IFC Films | false |
| 165 | Home | - | - | - | $1,874 | 2 | $15,925 | Nov 27 | Lorber Films | false |
| 166 | Drool | - | - | - | $1,403 | 1 | $1,403 | Jan 22 | Strand Releasing | false |
| 167 | Monsieur Verdoux | - | - | - | $1,239 | 2 | $64,636 | Mar 14 | The Film Desk | false |
| 168 | Trucker | - | - | - | $1,173 | 13 | $52,429 | Oct 9 | Monterey Media | false |
| 169 | Endgame | - | - | - | $1,118 | 14 | $9,645 | Nov 6 | Monterey Media | false |
| 170 | $9.99 | - | - | - | $821 | 4 | $52,384 | Dec 12 | Regent Releasing | false |
| 171 | Shall We Kiss? | - | - | - | $814 | 33 | $535,499 | Mar 27 | Music Box Films | false |
| 172 | Peter and Vandy | - | - | - | $734 | 3 | $11,495 | Oct 9 | Strand Releasing | false |
| 173 | Yuri Gagarin Conspiracy: Fallen Idol | - | - | - | $633 | 2 | $14,471 | Oct 2 | Indican Pictures | false |
| 174 | 45365 | - | - | - | $462 | 1 | $853 | Feb 26 | - | false |
| 175 | From Mexico with Love | - | - | - | $12 | 279 | $548,787 | Oct 9 | Roadside Attractions | false |
