| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Fatal Attraction | - | - | - | $105,617,098 | 1,401 | $156,645,693 | Sep 18 | Paramount Pictures | false |
| 2 | Three Men and a Baby | - | - | - | $70,801,611 | 1,813 | $167,780,960 | Nov 25 | Walt Disney Studios Motion Pictures | false |
| 3 | Planes, Trains & Automobiles | - | - | - | $35,049,149 | 1,684 | $49,530,280 | Nov 25 | Paramount Pictures | false |
| 4 | The Running Man | - | - | - | $34,879,267 | 1,694 | $38,122,105 | Nov 13 | TriStar Pictures | false |
| 5 | Like Father Like Son | - | - | - | $34,377,585 | 1,277 | $34,377,585 | Oct 2 | TriStar Pictures | false |
| 6 | Throw Momma from the Train | - | - | - | $30,715,258 | 1,623 | $57,915,972 | Dec 11 | Orion Pictures | false |
| 7 | The Princess Bride | - | - | - | $30,603,543 | 803 | $30,857,814 | Sep 25 | Twentieth Century Fox | false |
| 8 | Cinderella 1987 Re-release | - | - | - | $28,112,107 | 1,657 | $34,101,149 | Nov 20 | Walt Disney Studios Motion Pictures | false |
| 9 | Eddie Murphy: Raw | - | - | - | $26,939,719 | 1,494 | $50,504,655 | Dec 18 | Paramount Pictures | false |
| 10 | Baby Boom | - | - | - | $26,712,476 | 892 | $26,712,476 | Oct 9 | United Artists | false |
| 11 | Dirty Dancing | - | - | - | $23,885,066 | 1,012 | $63,446,382 | Aug 21 | Vestron Pictures | false |
| 12 | Nuts | - | - | - | $22,797,978 | 1,112 | $30,950,002 | Nov 20 | Warner Bros. | false |
| 13 | Hello Again | - | - | - | $20,419,446 | 1,207 | $20,419,446 | Nov 6 | Walt Disney Studios Motion Pictures | false |
| 14 | Wall Street | - | - | - | $18,012,690 | 989 | $43,848,069 | Dec 11 | Twentieth Century Fox | false |
| 15 | Suspect | - | - | - | $17,422,112 | 1,029 | $18,782,400 | Oct 23 | TriStar Pictures | false |
| 16 | Flowers in the Attic | - | - | - | $15,151,736 | 1,095 | $15,151,736 | Nov 20 | New World Pictures | false |
| 17 | *batteries not included | - | - | - | $14,662,720 | 1,367 | $32,945,797 | Dec 18 | Universal Pictures | false |
| 18 | Prince of Darkness | - | - | - | $14,182,492 | 1,239 | $14,182,492 | Oct 23 | Universal Pictures | false |
| 19 | Less Than Zero | - | - | - | $12,396,383 | 871 | $12,396,383 | Nov 6 | Twentieth Century Fox | false |
| 20 | Fatal Beauty | - | - | - | $12,046,526 | 1,117 | $12,046,526 | Oct 30 | Metro-Goldwyn-Mayer (MGM) | false |
| 21 | Stakeout | - | - | - | $11,477,363 | 1,364 | $65,673,233 | Aug 7 | Walt Disney Studios Motion Pictures | false |
| 22 | Broadcast News | - | - | - | $10,319,235 | 848 | $51,249,404 | Dec 18 | Twentieth Century Fox | false |
| 23 | Someone to Watch Over Me | - | - | - | $10,278,549 | 894 | $10,278,549 | Oct 9 | Columbia Pictures | false |
| 24 | The Principal | - | - | - | $10,040,711 | 1,196 | $19,734,940 | Sep 18 | TriStar Pictures | false |
| 25 | The Hidden | - | - | - | $9,747,988 | 1,045 | $9,747,988 | Oct 30 | New Line Cinema | false |
| 26 | Overboard | - | - | - | $9,415,897 | 1,135 | $26,713,187 | Dec 18 | Metro-Goldwyn-Mayer (MGM) | false |
| 27 | Empire of the Sun | - | - | - | $8,794,582 | 673 | $22,238,696 | Dec 11 | Warner Bros. | false |
| 28 | Teen Wolf Too | - | - | - | $7,888,703 | 1,540 | $7,888,703 | Nov 20 | Atlantic Releasing Corporation | false |
| 29 | Hiding Out | - | - | - | $7,019,441 | 988 | $7,019,441 | Nov 6 | De Laurentiis Entertainment Group (DEG) | false |
| 30 | Death Wish 4: The Crackdown | - | - | - | $6,880,310 | 1,030 | $6,880,310 | Nov 6 | Cannon Film Distributors | false |
| 31 | Hellraiser | - | - | - | $5,955,250 | 1,104 | $14,564,027 | Sep 18 | New World Pictures | false |
| 32 | Surrender | - | - | - | $5,711,976 | 1,067 | $5,711,976 | Oct 9 | Warner Bros. | false |
| 33 | The Sicilian | - | - | - | $5,406,879 | 370 | $5,406,879 | Oct 23 | Twentieth Century Fox | false |
| 34 | The Pick-up Artist | - | - | - | $5,286,816 | 1,132 | $13,290,368 | Sep 18 | Twentieth Century Fox | false |
| 35 | No Way Out | - | - | - | $5,004,944 | 1,130 | $35,509,515 | Aug 14 | Orion Pictures | false |
| 36 | La Bamba | - | - | - | $4,947,539 | 1,251 | $54,215,416 | Jul 24 | Columbia Pictures | false |
| 37 | Made in Heaven | - | - | - | $4,572,845 | 898 | $4,572,845 | Nov 6 | Lorimar Motion Pictures | false |
| 38 | The Last Emperor | - | - | - | $4,441,496 | 877 | $43,984,230 | Nov 20 | Columbia Pictures | false |
| 39 | The Dead | - | - | - | $4,370,078 | 6 | $4,370,078 | Dec 18 | Vestron Pictures | false |
| 40 | Leonard Part 6 | - | - | - | $3,891,660 | 1,149 | $4,615,255 | Dec 18 | Columbia Pictures | false |
| 41 | Three O'Clock High | - | - | - | $3,685,862 | 849 | $3,685,862 | Oct 9 | Universal Pictures | false |
| 42 | Big Shots | - | - | - | $3,390,043 | 932 | $3,390,043 | Oct 2 | Twentieth Century Fox | false |
| 43 | Near Dark | - | - | - | $3,369,307 | 429 | $3,369,307 | Oct 2 | De Laurentiis Entertainment Group (DEG) | false |
| 44 | Can't Buy Me Love | - | - | - | $3,365,318 | 1,283 | $31,623,833 | Aug 14 | Walt Disney Studios Motion Pictures | false |
| 45 | Best Seller | - | - | - | $3,224,697 | 253 | $4,278,150 | Sep 25 | Orion Pictures | false |
| 46 | Barfly | - | - | - | $3,221,568 | 2 | $3,221,568 | Oct 16 | Cannon Film Distributors | false |
| 47 | Sign 'o' the Times | - | - | - | $3,000,073 | 234 | $3,000,073 | Nov 20 | - | false |
| 48 | No Man's Land | - | - | - | $2,877,571 | 510 | $2,877,571 | Oct 23 | Orion Pictures | false |
| 49 | Hello Mary Lou: Prom Night II | - | - | - | $2,683,519 | 343 | $2,683,519 | Oct 16 | The Samuel Goldwyn Company | false |
| 50 | RoboCop | - | - | - | $2,681,759 | 1,601 | $53,424,681 | Jul 17 | Orion Pictures | false |
| 51 | House of Games | - | - | - | $2,585,639 | 9 | $2,585,639 | Oct 16 | Orion Pictures | false |
| 52 | Russkies | - | - | - | $2,189,047 | 604 | $2,189,047 | Nov 6 | New Century | false |
| 53 | The Big Easy | - | - | - | $2,166,506 | 1,219 | $17,685,307 | Aug 21 | Columbia Pictures | false |
| 54 | Weeds | - | - | - | $2,115,382 | 86 | $2,325,444 | Oct 16 | De Laurentiis Entertainment Group (DEG) | false |
| 55 | Date with an Angel | - | - | - | $1,988,962 | 843 | $1,988,962 | Nov 20 | De Laurentiis Entertainment Group (DEG) | false |
| 56 | Matewan | - | - | - | $1,641,247 | 42 | $1,680,358 | Aug 28 | Cinecom Pictures | false |
| 57 | From a Whisper to a Scream | - | - | - | $1,200,737 | 137 | $1,355,728 | Sep 4 | Moviestore Entertainment | false |
| 58 | Dancers | - | - | - | $1,190,416 | 12 | $1,190,416 | Oct 9 | Cannon Film Distributors | false |
| 59 | Cry Freedom | - | - | - | $1,180,156 | 479 | $5,899,797 | Nov 6 | Universal Pictures | false |
| 60 | Housekeeping | - | - | - | $1,083,282 | 2 | $1,083,282 | Nov 25 | Columbia Pictures | false |
| 61 | Cross My Heart | - | - | - | $1,025,762 | 205 | $1,025,762 | Nov 13 | Universal Pictures | false |
| 62 | The Big Town | - | - | - | $797,612 | 762 | $1,733,017 | Sep 25 | Columbia Pictures | false |
| 63 | Chuck Berry: Hail! Hail! Rock 'n' Roll | - | - | - | $719,323 | 33 | $719,323 | Oct 9 | Universal Pictures | false |
| 64 | China Girl | - | - | - | $717,159 | 193 | $1,262,091 | Sep 25 | Vestron Pictures | false |
| 65 | Real Men | - | - | - | $606,383 | 150 | $873,903 | Sep 25 | United Artists | false |
| 66 | Moonstruck | - | - | - | $606,289 | 1,178 | $80,640,528 | Dec 18 | Metro-Goldwyn-Mayer (MGM) | false |
| 67 | In the Mood | - | - | - | $605,244 | 361 | $999,382 | Sep 16 | Lorimar Motion Pictures | false |
| 68 | Steel Dawn | - | - | - | $562,187 | 290 | $562,187 | Nov 6 | Vestron Pictures | false |
| 69 | Man on Fire | - | - | - | $519,596 | 178 | $519,596 | Oct 9 | TriStar Pictures | false |
| 70 | Oviri | - | - | - | $518,520 | 16 | $583,800 | Jul 31 | International Film Marketing | false |
| 71 | September | - | - | - | $486,434 | 15 | $486,434 | Dec 18 | Orion Pictures | false |
| 72 | Good Morning, Vietnam | - | - | - | $440,103 | 1,598 | $123,922,370 | Dec 25 | Walt Disney Studios Motion Pictures | false |
| 73 | Slam Dance | - | - | - | $406,881 | 47 | $406,881 | Oct 2 | Island Pictures | false |
| 74 | Cold Steel | - | - | - | $285,885 | 135 | $285,885 | Dec 11 | Cinetel | false |
| 75 | Orphans | - | - | - | $230,756 | 25 | $252,430 | Sep 18 | Lorimar Motion Pictures | false |
| 76 | Ironweed | - | - | - | $148,768 | 600 | $7,393,346 | Dec 18 | TriStar Pictures | false |
| 77 | Sammy and Rosie Get Laid | - | - | - | $55,308 | 15 | $1,196,336 | Oct 30 | Cinecom Pictures | false |
| 78 | Hope and Glory | - | - | - | $38,293 | 328 | $10,021,120 | Oct 16 | Columbia Pictures | false |
| 79 | Siesta | - | - | - | $32,041 | 30 | $700,000 | Nov 11 | Lorimar Motion Pictures | false |
| 80 | Zombie High | - | - | - | $21,905 | 25 | $21,905 | Oct 2 | - | false |
