| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Crocodile Dundee II | - | - | - | $82,116,373 | 2,837 | $109,306,210 | May 25 | Paramount Pictures | false |
| 2 | Beetlejuice | - | - | - | $73,707,461 | 1,582 | $73,707,461 | Mar 30 | Warner Bros. | false |
| 3 | Rambo III | - | - | - | $47,738,455 | 2,562 | $53,715,611 | May 25 | TriStar Pictures | false |
| 4 | Colors | - | - | - | $46,616,067 | 1,388 | $46,616,067 | Apr 15 | Orion Pictures | false |
| 5 | Big | - | - | - | $46,439,069 | 1,419 | $114,968,774 | Jun 3 | Twentieth Century Fox | false |
| 6 | Willow | - | - | - | $41,097,483 | 1,209 | $57,269,863 | May 20 | Metro-Goldwyn-Mayer (MGM) | false |
| 7 | Biloxi Blues | - | - | - | $32,825,128 | 1,330 | $43,184,798 | Mar 25 | Universal Pictures | false |
| 8 | Moonstruck | - | - | - | $24,722,869 | 1,178 | $80,640,528 | Dec 18 | Metro-Goldwyn-Mayer (MGM) | false |
| 9 | Big Business | - | - | - | $23,063,360 | 1,232 | $40,150,487 | Jun 10 | Walt Disney Studios Motion Pictures | false |
| 10 | Who Framed Roger Rabbit | - | - | - | $22,711,133 | 1,598 | $156,452,370 | Jun 24 | Walt Disney Studios Motion Pictures | false |
| 11 | Funny Farm | - | - | - | $21,448,006 | 1,557 | $25,537,221 | Jun 3 | Warner Bros. | false |
| 12 | The Last Emperor | - | - | - | $20,485,992 | 877 | $43,984,230 | Nov 20 | Columbia Pictures | false |
| 13 | Red Heat | - | - | - | $20,288,175 | 1,892 | $34,994,648 | Jun 17 | TriStar Pictures | false |
| 14 | Good Morning, Vietnam | - | - | - | $20,089,703 | 1,598 | $123,922,370 | Dec 25 | Walt Disney Studios Motion Pictures | false |
| 15 | Friday the 13th: The New Blood | - | - | - | $19,170,001 | 1,796 | $19,170,001 | May 13 | Paramount Pictures | false |
| 16 | The Seventh Sign | - | - | - | $18,875,011 | 1,258 | $18,875,011 | Apr 1 | TriStar Pictures | false |
| 17 | Above the Law | - | - | - | $18,869,631 | 868 | $18,869,631 | Apr 8 | Warner Bros. | false |
| 18 | The Great Outdoors | - | - | - | $18,835,288 | 1,430 | $41,455,230 | Jun 17 | Universal Pictures | false |
| 19 | Bull Durham | - | - | - | $16,532,013 | 1,297 | $50,888,729 | Jun 17 | Orion Pictures | false |
| 20 | Bright Lights, Big City | - | - | - | $16,118,077 | 1,199 | $16,118,077 | Apr 1 | United Artists | false |
| 21 | The Fox and the Hound 1988 Re-release | - | - | - | $16,072,087 | 1,567 | $23,556,988 | Mar 25 | Walt Disney Studios Motion Pictures | false |
| 22 | The Presidio | - | - | - | $14,390,684 | 1,168 | $20,324,096 | Jun 10 | Paramount Pictures | false |
| 23 | Return to Snowy River | - | - | - | $13,687,027 | 1,121 | $13,687,027 | Apr 15 | Walt Disney Studios Motion Pictures | false |
| 24 | The Milagro Beanfield War | - | - | - | $13,592,887 | 437 | $13,825,794 | Mar 18 | Universal Pictures | false |
| 25 | Casual Sex? | - | - | - | $12,277,096 | 1,265 | $12,277,096 | Apr 22 | Universal Pictures | false |
| 26 | Stand and Deliver | - | - | - | $11,701,419 | 472 | $13,994,920 | Mar 11 | Warner Bros. | false |
| 27 | Poltergeist III | - | - | - | $11,167,786 | 1,471 | $14,114,488 | Jun 10 | Metro-Goldwyn-Mayer (MGM) | false |
| 28 | Johnny Be Good | - | - | - | $10,235,789 | 1,194 | $17,550,399 | Mar 25 | Orion Pictures | false |
| 29 | Shakedown | - | - | - | $10,068,039 | 1,580 | $10,068,039 | May 6 | Universal Pictures | false |
| 30 | Bad Dreams | - | - | - | $9,797,098 | 1,185 | $9,797,098 | Apr 8 | Twentieth Century Fox | false |
| 31 | Salsa | - | - | - | $8,892,589 | 1,125 | $8,892,589 | May 6 | Cannon Film Distributors | false |
| 32 | Three Men and a Baby | - | - | - | $7,596,550 | 1,813 | $167,780,960 | Nov 25 | Walt Disney Studios Motion Pictures | false |
| 33 | Police Academy 5: Assignment: Miami Beach | - | - | - | $6,982,470 | 1,700 | $19,510,371 | Mar 18 | Warner Bros. | false |
| 34 | The Unholy | - | - | - | $6,337,299 | 1,189 | $6,337,299 | Apr 22 | Vestron Pictures | false |
| 35 | Fatal Attraction | - | - | - | $5,612,019 | 1,401 | $156,645,693 | Sep 18 | Paramount Pictures | false |
| 36 | The Unbearable Lightness of Being | - | - | - | $5,242,069 | 140 | $10,006,806 | Feb 5 | Orion Pictures | false |
| 37 | Sunset | - | - | - | $4,594,452 | 1,024 | $4,594,452 | Apr 29 | TriStar Pictures | false |
| 38 | Masquerade | - | - | - | $4,335,120 | 1,031 | $15,855,828 | Mar 11 | Metro-Goldwyn-Mayer (MGM) | false |
| 39 | A New Life | - | - | - | $4,246,843 | 796 | $7,721,852 | Mar 25 | Paramount Pictures | false |
| 40 | D.O.A. | - | - | - | $4,129,700 | 908 | $12,706,478 | Mar 18 | Walt Disney Studios Motion Pictures | false |
| 41 | Critters 2: The Main Course | - | - | - | $3,813,293 | 1,114 | $3,813,293 | Apr 29 | New Line Cinema | false |
| 42 | Broadcast News | - | - | - | $3,702,642 | 848 | $51,249,404 | Dec 18 | Twentieth Century Fox | false |
| 43 | Dead Heat | - | - | - | $3,588,626 | 1,012 | $3,588,626 | May 6 | New World Pictures | false |
| 44 | White Mischief | - | - | - | $3,107,551 | 87 | $3,107,551 | Apr 22 | Columbia Pictures | false |
| 45 | Hope and Glory | - | - | - | $2,755,282 | 328 | $10,021,120 | Oct 16 | Columbia Pictures | false |
| 46 | Dominick and Eugene | - | - | - | $2,673,966 | 76 | $3,076,031 | Mar 18 | Orion Pictures | false |
| 47 | The Manchurian Candidate 1988 Re-release | - | - | - | $2,643,053 | 49 | $2,757,256 | Feb 12 | Metro-Goldwyn-Mayer (MGM) | false |
| 48 | 18 Again! | - | - | - | $2,567,099 | 1,152 | $2,567,099 | Apr 8 | New World Pictures | false |
| 49 | Vice Versa | - | - | - | $2,387,681 | 1,225 | $13,664,060 | Mar 11 | Columbia Pictures | false |
| 50 | Hairspray | - | - | - | $2,220,353 | 227 | $6,671,108 | Feb 26 | New Line Cinema | false |
| 51 | The Moderns | - | - | - | $2,011,497 | 28 | $2,011,497 | Apr 15 | Alive Films | false |
| 52 | Stormy Monday | - | - | - | $1,791,328 | 49 | $1,791,328 | Apr 22 | Atlantic Releasing Corporation | false |
| 53 | Lady in White | - | - | - | $1,705,139 | 107 | $1,705,139 | Apr 22 | New Century | false |
| 54 | Two Moon Junction | - | - | - | $1,547,397 | 458 | $1,547,397 | Apr 29 | Lorimar Motion Pictures | false |
| 55 | A Time of Destiny | - | - | - | $1,212,487 | 220 | $1,212,487 | Apr 22 | Columbia Pictures | false |
| 56 | Aria | - | - | - | $1,018,105 | 34 | $1,028,679 | Mar 18 | Miramax | false |
| 57 | Appointment with Death | - | - | - | $960,040 | 465 | $960,040 | Apr 15 | Cannon Film Distributors | false |
| 58 | Bulletproof | - | - | - | $807,947 | 268 | $807,947 | May 13 | Universal Pictures | false |
| 59 | Maniac Cop | - | - | - | $671,382 | 50 | $671,382 | May 13 | Shapiro-Glickenhaus Entertainment | false |
| 60 | Da | - | - | - | $644,532 | 1 | $644,532 | Apr 29 | FilmDallas Pictures | false |
| 61 | Powaqqatsi | - | - | - | $589,244 | 22 | $589,244 | Apr 29 | Cannon Film Distributors | false |
| 62 | The Decline of Western Civilization Part II: The Metal Years | - | - | - | $373,743 | 21 | $373,743 | Jun 3 | New Line Cinema | false |
| 63 | Prison | - | - | - | $345,704 | 42 | $345,704 | May 6 | New World Pictures | false |
| 64 | Plain Clothes | - | - | - | $289,323 | 193 | $289,323 | Apr 15 | Paramount Pictures | false |
| 65 | Sammy and Rosie Get Laid | - | - | - | $258,321 | 15 | $1,196,336 | Oct 30 | Cinecom Pictures | false |
| 66 | Judgment in Berlin | - | - | - | $229,556 | 81 | $229,556 | May 6 | New Line Cinema | false |
| 67 | Beatrice | - | - | - | $193,983 | 8 | $211,821 | Mar 18 | The Samuel Goldwyn Company | false |
| 68 | Mondo New York | - | - | - | $193,209 | 1 | $193,209 | Apr 22 | Fourth and Broadway | false |
| 69 | My Best Friend Is a Vampire | - | - | - | $174,380 | 170 | $174,380 | May 6 | Kings Road Entertainment | false |
| 70 | Consuming Passions | - | - | - | $118,206 | 5 | $118,206 | Apr 6 | The Samuel Goldwyn Company | false |
| 71 | Little Nikita | - | - | - | $118,077 | 376 | $1,733,070 | Mar 18 | Columbia Pictures | false |
| 72 | The Kitchen Toto | - | - | - | $101,807 | 4 | $101,807 | May 13 | Cannon Film Distributors | false |
| 73 | A Handful of Dust | - | - | - | $56,208 | 29 | $1,560,700 | Jun 24 | New Line Cinema | false |
| 74 | A World Apart | - | - | - | $35,835 | 42 | $2,326,860 | Jun 17 | Atlantic Releasing Corporation | false |
| 75 | The Lighthorsemen | - | - | - | $33,779 | 16 | $33,779 | Apr 8 | Cinecom Pictures | false |
| 76 | Wings of Desire | - | - | - | $30,639 | 29 | $3,210,139 | Apr 29 | Orion Classics | false |
| 77 | Bellman and True | - | - | - | $30,423 | 8 | $226,944 | Apr 1 | Island Pictures | false |
