| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Shang-Chi and the Legend of the Ten Rings | - | - | - | $6,303,986 | 341 | $6,968,395 | Sep 3 | Walt Disney Studios Motion Pictures | false |
| 2 | Dune: Part One | - | - | - | $4,847,710 | 746 | $9,037,705 | Sep 17 | Warner Bros. | false |
| 3 | After We Fell | - | - | - | $2,696,955 | 352 | $2,696,955 | Sep 3 | Diamond Films | false |
| 4 | PAW Patrol: The Movie | - | - | - | $2,011,255 | 352 | $3,507,087 | Aug 27 | Paramount Pictures | false |
| 5 | Malignant | - | - | - | $1,977,069 | 313 | $2,126,260 | Sep 3 | Warner Bros. | false |
| 6 | Free Guy | - | - | - | $1,483,619 | 325 | $3,607,833 | Aug 18 | Walt Disney Pictures | false |
| 7 | Maixabel | - | - | - | $1,080,075 | 364 | $3,176,720 | Sep 24 | Walt Disney Pictures | false |
| 8 | Cruella | - | - | - | $1,055,532 | 341 | $5,547,335 | May 28 | Walt Disney Studios Motion Pictures | false |
| 9 | The Boss Baby 2: Family Business | - | - | - | $915,453 | 403 | $5,239,010 | Aug 6 | Universal Pictures International (UPI) | false |
| 10 | Garcia & Garcia | - | - | - | $792,182 | 304 | $1,133,254 | Aug 27 | A Contracorriente Films | false |
| 11 | Candyman | - | - | - | $674,560 | 293 | $1,042,031 | Aug 27 | Universal Pictures | false |
| 12 | ¡A todo tren! Destino Asturias | - | - | - | $670,331 | 400 | $9,544,171 | Jul 9 | Warner Bros. | false |
| 13 | The Suicide Squad | - | - | - | $596,598 | 346 | $5,316,600 | Aug 6 | Warner Bros. | false |
| 14 | Jungle Cruise | - | - | - | $577,644 | 398 | $4,078,906 | Jul 30 | Walt Disney Studios Motion Pictures | false |
| 15 | Old | - | - | - | $527,180 | 366 | $5,626,313 | Jul 30 | Universal Pictures | false |
| 16 | Family Swap | - | - | - | $523,067 | 194 | $818,538 | Sep 10 | DeAPlaneta | false |
| 17 | Don't Breathe 2 | - | - | - | $471,167 | 315 | $2,071,084 | Sep 24 | Sony Pictures Releasing | false |
| 18 | Dogtanian and the Three Muskehounds | - | - | - | $445,350 | 609 | $1,291,150 | Sep 3 | A Contracorriente Films | false |
| 19 | Escape Room: Tournament of Champions | - | - | - | $443,195 | 314 | $2,108,773 | Aug 13 | Sony Pictures Releasing | false |
| 20 | Black Widow | - | - | - | $349,551 | 349 | $7,329,424 | Jul 9 | Walt Disney Pictures | false |
| 21 | Reminiscence | - | - | - | $289,727 | 305 | $506,731 | Aug 27 | Warner Bros. | false |
| 22 | Cry Macho | - | - | - | $279,754 | 277 | $836,029 | Sep 24 | Warner Bros. | false |
| 23 | Interrail | - | - | - | $256,534 | 357 | $1,137,284 | Aug 20 | Sony Pictures Releasing | false |
| 24 | Space Jam: A New Legacy | - | - | - | $234,433 | 368 | $5,066,019 | Jul 23 | Warner Bros. | false |
| 25 | Chavalas | - | - | - | $232,793 | 73 | $265,314 | Sep 3 | Filmax | false |
| 26 | Bye Bye Morons | - | - | - | $192,654 | 86 | $193,797 | Sep 10 | - | false |
| 27 | Con quién viajas | - | - | - | $140,490 | 221 | $145,094 | Sep 10 | A Contracorriente Films | false |
| 28 | F9: The Fast Saga | - | - | - | $126,604 | 377 | $10,746,219 | Jul 2 | Universal Pictures | false |
| 29 | The Ogglies | - | - | - | $105,082 | 177 | $105,082 | Sep 3 | VerCine | false |
| 30 | The Ice Road | - | - | - | $101,417 | 160 | $197,758 | Aug 27 | Entertainment One | false |
| 31 | Annette | - | - | - | $76,422 | 61 | $231,563 | Aug 20 | Elastica | false |
| 32 | Respect | - | - | - | $73,891 | 140 | $212,929 | Sep 24 | Universal Pictures | false |
| 33 | Nora | - | - | - | $54,354 | 26 | $65,505 | Sep 3 | Sherlock Films | false |
| 34 | Gunpowder Milkshake | - | - | - | $51,806 | 221 | $51,806 | Sep 10 | Vértice 360 | false |
| 35 | Worth | - | - | - | $51,750 | 109 | $51,750 | Sep 10 | Vértigo Films | false |
| 36 | Raya and the Last Dragon | - | - | - | $37,328 | 149 | $2,944,461 | Mar 5 | Walt Disney Pictures | false |
| 37 | Descarrilados | - | - | - | $36,901 | 350 | $1,147,367 | Aug 20 | Sony Pictures Releasing | false |
| 38 | Josee, the Tiger and the Fish | - | - | - | $27,589 | 82 | $27,589 | Sep 10 | Selecta Visión | false |
| 39 | Undercover Wedding Crashers | - | - | - | $23,976 | 353 | $3,871,185 | Jun 25 | Walt Disney Pictures | false |
| 40 | Riders of Justice | - | - | - | $22,023 | 95 | $160,486 | Aug 13 | Alfa Films | false |
| 41 | Claret | - | - | - | $21,617 | 39 | $76,564 | Sep 24 | - | false |
| 42 | Checkered Ninja 2 | - | - | - | $20,536 | 135 | $86,583 | Sep 17 | - | false |
| 43 | Sevillanas de Brooklyn | - | - | - | $16,462 | 100 | $126,635 | Sep 17 | Filmax | false |
| 44 | The Unemployment Club | - | - | - | $5,021 | 66 | $61,315 | Sep 17 | Vértice 360 | false |
| 45 | The Consequences | - | - | - | $2,962 | 25 | $28,334 | Sep 17 | Syldavia Cinema | false |
| 46 | Negro Purpura | - | - | - | $2,530 | 8 | $10,370 | Sep 24 | Begin Again Films | false |
| 47 | Un tiempo precioso | - | - | - | $696 | 1 | $1,115 | - | - | false |
| 48 | Inheritance | - | - | - | $422 | 1 | $1,523 | May 14 | Begin Again Films | false |
| 49 | Spiral | - | - | - | $273 | 280 | $1,160,969 | May 21 | DeAPlaneta | false |
| 50 | Surcos | - | - | - | $161 | 7 | $8,932 | May 28 | Phoenix Productions (II) | false |
| 51 | Billy | - | - | - | $113 | 2 | $4,578 | Sep 17 | Begin Again Films | false |
| 52 | Ara Malikian: una vida entre las cuerdas | - | - | - | $94 | 2 | $34,435 | Oct 25 | Syldavia Cinema | false |
| 53 | Pain and Glory | - | - | - | $73 | 464 | $6,665,749 | Mar 22 | Sony Pictures Releasing | false |
| 54 | My Heart Goes Boom! | - | - | - | $69 | 1 | $584,939 | Oct 2 | United International Pictures | false |
| 55 | Dancing Beethoven 2021 Re-release | - | - | - | $61 | 1 | $10,815 | - | Márgenes Distribución | false |
| 56 | Father There is Only One 2 | - | - | - | $48 | 723 | $15,373,181 | Jul 31 | Sony Pictures Releasing | false |
| 57 | The Mole Agent | - | - | - | $29 | 2 | $189,818 | Mar 19 | BTeam Pictures | false |
| 58 | Ama | - | - | - | $26 | 15 | $25,110 | Jul 16 | Filmax | false |
| 59 | Coming Soon Last Days | - | - | - | $24 | 1 | $351 | Aug 27 | - | false |
| 60 | Herederas | - | - | - | $8 | 1 | $209 | Aug 27 | - | false |
