| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Captain Alatriste: The Spanish Musketeer | - | - | - | $18,488,578 | 450 | $21,215,090 | Sep 1 | 20th Century Fox International | false |
| 2 | Miami Vice | - | - | - | $5,295,003 | 292 | $4,417,672 | Sep 8 | United International Pictures | false |
| 3 | Monster House | - | - | - | $4,466,484 | 350 | $5,456,949 | Sep 1 | Sony Pictures Releasing | false |
| 4 | Little Man | - | - | - | $4,121,131 | 250 | $6,398,603 | Sep 15 | Sony Pictures Releasing | false |
| 5 | Pirates of the Caribbean: Dead Man's Chest | - | - | - | $3,761,581 | 787 | $36,609,592 | Aug 11 | Buena Vista International | false |
| 6 | Garfield: A Tail of Two Kitties | - | - | - | $3,625,708 | 415 | $8,584,642 | Aug 25 | 20th Century Fox International | false |
| 7 | The Break-Up | - | - | - | $2,933,090 | 228 | $4,154,697 | Sep 15 | United International Pictures | false |
| 8 | Lady in the Water | - | - | - | $2,827,459 | 328 | $5,728,908 | Aug 25 | Warner Bros. | false |
| 9 | Salvador | - | - | - | $1,913,579 | 190 | $3,235,528 | Sep 15 | Warner Bros. | false |
| 10 | United 93 | - | - | - | $1,803,765 | 134 | $3,579,543 | Aug 23 | United International Pictures | false |
| 11 | The Ant Bully | - | - | - | $1,697,767 | 265 | $2,181,265 | Sep 8 | Warner Bros. | false |
| 12 | Edison | - | - | - | $1,512,402 | 144 | $1,623,929 | Sep 1 | Filmax | false |
| 13 | Hoodwinked! | - | - | - | $1,378,797 | 258 | $4,161,423 | Sep 22 | Manga Entertainment | false |
| 14 | My Super Ex-Girlfriend | - | - | - | $1,138,312 | 299 | $2,027,732 | Sep 22 | 20th Century Fox International | false |
| 15 | The Wind that Shakes the Barley | - | - | - | $921,922 | 109 | $1,570,172 | Sep 15 | Alta Films | false |
| 16 | The Night of the Sunflowers | - | - | - | $755,648 | 90 | $1,123,189 | Aug 25 | Alta Films | false |
| 17 | An American Haunting | - | - | - | $672,013 | 242 | $3,103,045 | Aug 18 | DeAPlaneta | false |
| 18 | The Lazarus Child | - | - | - | $534,327 | 145 | $1,020,226 | Sep 22 | Aurum Films | false |
| 19 | La máquina de bailar | - | - | - | $507,121 | 249 | $653,124 | Sep 22 | United International Pictures | false |
| 20 | Clerks II | - | - | - | $397,603 | 124 | $397,603 | Sep 8 | DeAPlaneta | false |
| 21 | Stay Alive | - | - | - | $218,851 | 55 | $218,851 | Sep 1 | United International Pictures | false |
| 22 | Nine Lives | - | - | - | $156,410 | 23 | $698,093 | Sep 22 | Versus Entertainment | false |
| 23 | The Man | - | - | - | $156,200 | 148 | $275,435 | Sep 15 | TriPictures | false |
| 24 | The Near East | - | - | - | $147,635 | 106 | $775,228 | Aug 18 | 20th Century Fox International | false |
| 25 | Breakfast on Pluto | - | - | - | $125,993 | 49 | $408,071 | Aug 25 | Vértigo Films | false |
| 26 | Something Like Happiness | - | - | - | $109,130 | 20 | $196,260 | Sep 8 | Golem Distribución | false |
| 27 | Kinky Boots | - | - | - | $106,128 | 83 | $106,128 | Sep 8 | Buena Vista International | false |
| 28 | C.R.A.Z.Y. | - | - | - | $96,723 | 30 | $622,932 | Aug 4 | Golem Distribución | false |
| 29 | Open Water 2: Adrift | - | - | - | $95,772 | 153 | $1,034,542 | Aug 18 | On Pictures | false |
| 30 | Thank You for Smoking | - | - | - | $91,021 | 64 | $318,929 | Sep 22 | 20th Century Fox International | false |
| 31 | The Myth | - | - | - | $86,209 | 87 | $86,209 | Sep 1 | Manga Entertainment | false |
| 32 | Bandidas | - | - | - | $67,192 | 250 | $4,370,015 | Aug 4 | 20th Century Fox International | false |
| 33 | Sex Crazy | - | - | - | $66,659 | 118 | $327,490 | Aug 25 | Filmax | false |
| 34 | Skizo | - | - | - | $57,881 | 128 | $57,881 | Sep 8 | Aurum Films | false |
| 35 | The Sentinel | - | - | - | $53,348 | 285 | $6,255,372 | Jul 21 | 20th Century Fox International | false |
| 36 | Arena en los bolsillos | - | - | - | $45,560 | 58 | $45,560 | Sep 8 | Filmax | false |
| 37 | Poseidon | - | - | - | $42,276 | 429 | $8,550,398 | Jul 28 | Warner Bros. | false |
| 38 | Cars | - | - | - | $41,756 | 556 | $16,342,337 | Jul 7 | Buena Vista International | false |
| 39 | Enduring Love 2006 Re-release | - | - | - | $39,156 | 36 | $39,156 | Sep 1 | Karma Films | false |
| 40 | A Home at the End of the World 2006 Re-release | - | - | - | $36,322 | 27 | $95,698 | Sep 15 | Manga Entertainment | false |
