| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Step Up 3D | - | - | - | $210,708 | 8 | $333,928 | Sep 22 | - | false |
| 2 | Eat Pray Love | - | - | - | $180,429 | 6 | $245,414 | Oct 6 | Sony Pictures Releasing | false |
| 3 | Piranha 3D | - | - | - | $178,511 | 8 | $194,508 | Oct 6 | - | false |
| 4 | Inception | - | - | - | $103,471 | 8 | $860,632 | Jul 17 | Warner Bros. | false |
| 5 | Resident Evil: Afterlife | - | - | - | $98,067 | 10 | $156,129 | Oct 20 | United Motion Pictures | false |
| 6 | Wall Street: Money Never Sleeps | - | - | - | $78,785 | 4 | $78,785 | Sep 29 | 20th Century Fox International | false |
| 7 | Despicable Me | - | - | - | $72,775 | 8 | $145,041 | Sep 15 | United International Pictures | false |
| 8 | The Town | - | - | - | $52,570 | 10 | $121,332 | Oct 27 | Warner Bros. | false |
| 9 | The Sorcerer's Apprentice | - | - | - | $45,811 | 8 | $213,654 | Sep 1 | Walt Disney Pictures | false |
| 10 | The Collector | - | - | - | $44,309 | 6 | $48,196 | Oct 13 | - | false |
| 11 | Dinner for Schmucks | - | - | - | $41,621 | 8 | $45,679 | Oct 13 | United International Pictures | false |
| 12 | The American | - | - | - | $36,609 | 5 | $37,381 | Oct 13 | - | false |
| 13 | The Other Guys | - | - | - | $25,379 | 5 | $82,815 | Sep 15 | Sony Pictures Releasing | false |
| 14 | Splice 2010 Re-release | - | - | - | $25,353 | 8 | $35,241 | Sep 22 | - | false |
| 15 | The Social Network | - | - | - | $24,511 | 5 | $66,759 | Oct 27 | Sony Pictures Releasing | false |
| 16 | Charlie St. Cloud | - | - | - | $22,785 | 6 | $39,507 | Oct 20 | United International Pictures | false |
| 17 | Letters to Juliet | - | - | - | $22,143 | 6 | $22,143 | Sep 29 | - | false |
| 18 | Going the Distance | - | - | - | $19,381 | 4 | $37,718 | Sep 22 | Warner Bros. | false |
| 19 | Legend of the Guardians: The Owls of Ga'Hoole | - | - | - | $11,811 | 7 | $21,432 | Oct 27 | Warner Bros. | false |
| 20 | Furry Vengeance | - | - | - | $10,088 | 2 | $11,640 | Oct 13 | - | false |
| 21 | You Again | - | - | - | $9,769 | 3 | $10,332 | Oct 20 | Walt Disney Pictures | false |
| 22 | Knight and Day 2010 Re-release | - | - | - | $9,201 | 7 | $447,547 | Jun 30 | 20th Century Fox International | false |
| 23 | Cats & Dogs: The Revenge of Kitty Galore | - | - | - | $6,829 | 6 | $63,244 | Sep 8 | Warner Bros. | false |
| 24 | Predators | - | - | - | $5,290 | 5 | $59,082 | Aug 25 | 20th Century Fox International | false |
| 25 | Grown Ups | - | - | - | $2,732 | 5 | $158,395 | Aug 4 | Sony Pictures Releasing | false |
| 26 | Toy Story 3 | - | - | - | $1,192 | 4 | $435,046 | Jun 16 | Walt Disney Pictures | false |
| 27 | The Losers | - | - | - | $888 | 5 | $29,075 | Sep 1 | Warner Bros. | false |
| 28 | She's Out of My League | - | - | - | $794 | 5 | $54,380 | Jul 7 | United International Pictures | false |
| 29 | The Last Airbender | - | - | - | $333 | 8 | $192,167 | Jul 21 | United International Pictures | false |
| 30 | Shrek Forever After | - | - | - | $292 | 8 | $254,350 | Jun 30 | United International Pictures | false |
