| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Marked for Death | - | - | - | $34,298,985 | 1,974 | $46,044,396 | Oct 5 | Twentieth Century Fox | false |
| 2 | Ghost | - | - | - | $24,005,364 | 1,766 | $217,631,306 | Jul 13 | Paramount Pictures | false |
| 3 | Goodfellas | - | - | - | $21,251,369 | 1,328 | $46,836,214 | Sep 19 | Warner Bros. | false |
| 4 | Pacific Heights | - | - | - | $21,188,813 | 1,291 | $29,381,956 | Sep 28 | Twentieth Century Fox | false |
| 5 | Fantasia 1990 Re-release | - | - | - | $18,034,333 | 481 | $25,363,371 | Oct 5 | Walt Disney Studios Motion Pictures | false |
| 6 | Memphis Belle | - | - | - | $15,926,557 | 1,368 | $27,441,977 | Oct 12 | Warner Bros. | false |
| 7 | Postcards from the Edge | - | - | - | $14,512,320 | 1,323 | $39,071,603 | Sep 14 | Columbia Pictures | false |
| 8 | Mr. Destiny | - | - | - | $9,365,835 | 1,025 | $15,379,253 | Oct 12 | Walt Disney Studios Motion Pictures | false |
| 9 | Flatliners | - | - | - | $8,551,745 | 1,483 | $61,489,265 | Aug 10 | Columbia Pictures | false |
| 10 | Quigley Down Under | - | - | - | $8,122,108 | 1,094 | $21,413,105 | Oct 19 | Metro-Goldwyn-Mayer (MGM) | false |
| 11 | Avalon | - | - | - | $6,701,111 | 635 | $15,740,796 | Oct 5 | TriStar Pictures | false |
| 12 | Henry & June | - | - | - | $6,387,190 | 295 | $11,567,449 | Oct 5 | Universal Pictures | false |
| 13 | Presumed Innocent | - | - | - | $6,319,337 | 1,451 | $86,303,188 | Jul 27 | Warner Bros. | false |
| 14 | Death Warrant | - | - | - | $5,862,727 | 1,090 | $16,853,487 | Sep 14 | Metro-Goldwyn-Mayer (MGM) | false |
| 15 | Graveyard Shift | - | - | - | $5,562,150 | 1,603 | $11,582,891 | Oct 26 | Paramount Pictures | false |
| 16 | White Palace | - | - | - | $5,415,606 | 892 | $17,487,531 | Oct 19 | Universal Pictures | false |
| 17 | Narrow Margin | - | - | - | $5,142,635 | 1,253 | $10,873,237 | Sep 21 | TriStar Pictures | false |
| 18 | Night of the Living Dead | - | - | - | $4,822,140 | 1,544 | $5,835,247 | Oct 19 | Columbia Pictures | false |
| 19 | Pretty Woman | - | - | - | $4,444,517 | 1,811 | $178,406,268 | Mar 23 | Walt Disney Studios Motion Pictures | false |
| 20 | Sibling Rivalry | - | - | - | $4,436,796 | 1,455 | $17,854,933 | Oct 26 | Columbia Pictures | false |
| 21 | Welcome Home, Roxy Carmichael | - | - | - | $3,989,297 | 635 | $3,989,297 | Oct 12 | Paramount Pictures | false |
| 22 | Funny About Love | - | - | - | $3,609,256 | 1,213 | $8,141,292 | Sep 21 | Paramount Pictures | false |
| 23 | Miller's Crossing | - | - | - | $3,596,783 | 289 | $5,080,409 | Sep 21 | Twentieth Century Fox | false |
| 24 | Dark Angel | - | - | - | $3,239,119 | 1,041 | $4,348,368 | Sep 28 | Triumph Releasing Corporation | false |
| 25 | Desperate Hours | - | - | - | $2,742,912 | 1,033 | $2,742,912 | Oct 5 | Metro-Goldwyn-Mayer (MGM) | false |
| 26 | Def by Temptation | - | - | - | $2,135,997 | 57 | $2,218,579 | May 11 | Troma | false |
| 27 | Texasville | - | - | - | $1,795,817 | 354 | $2,268,181 | Sep 28 | Columbia Pictures | false |
| 28 | Bloodfist II | - | - | - | $1,292,323 | 92 | $1,292,323 | Oct 12 | Concorde Pictures | false |
| 29 | The Icicle Thief | - | - | - | $1,197,430 | 22 | $1,231,622 | Aug 24 | Aries Films | false |
| 30 | Corporate Affairs | - | - | - | $1,006,575 | 57 | $1,006,575 | Oct 5 | Concorde Pictures | false |
| 31 | State of Grace | - | - | - | $989,212 | 335 | $1,911,542 | Sep 14 | Orion Pictures | false |
| 32 | Reversal of Fortune | - | - | - | $903,782 | 661 | $15,445,131 | Oct 19 | Warner Bros. | false |
| 33 | The Tall Guy | - | - | - | $385,787 | 41 | $510,712 | Sep 21 | Miramax | false |
| 34 | King of New York | - | - | - | $328,992 | 119 | $2,554,476 | Sep 28 | New Line Cinema | false |
| 35 | The Hot Spot | - | - | - | $158,677 | 365 | $1,293,976 | Oct 12 | Orion Pictures | false |
| 36 | Tune in Tomorrow... | - | - | - | $74,256 | 207 | $1,794,001 | Oct 26 | Cinecom Pictures | false |
| 37 | Fools of Fortune | - | - | - | $65,572 | 9 | $83,490 | Sep 14 | New Line Cinema | false |
| 38 | The Spirit of '76 | - | - | - | $52,310 | 12 | $52,310 | Oct 12 | Columbia Pictures | false |
| 39 | To Sleep with Anger | - | - | - | $26,349 | 23 | $1,161,135 | Oct 12 | The Samuel Goldwyn Company | false |
| 40 | The Nasty Girl | - | - | - | $26,202 | 40 | $2,281,569 | Oct 26 | Miramax | false |
