| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Look Who's Talking | - | - | - | $44,050,981 | 1,651 | $140,088,813 | Oct 13 | TriStar Pictures | false |
| 2 | Black Rain | - | - | - | $23,471,037 | 1,760 | $46,212,055 | Sep 22 | Paramount Pictures | false |
| 3 | Sea of Love | - | - | - | $22,745,590 | 1,439 | $58,571,513 | Sep 15 | Universal Pictures | false |
| 4 | An Innocent Man | - | - | - | $16,120,309 | 1,561 | $20,047,604 | Oct 6 | Walt Disney Studios Motion Pictures | false |
| 5 | Uncle Buck | - | - | - | $13,000,330 | 1,835 | $66,758,538 | Aug 18 | Universal Pictures | false |
| 6 | When Harry Met Sally... | - | - | - | $11,439,161 | 1,174 | $92,823,546 | Jul 14 | Columbia Pictures | false |
| 7 | Halloween 5: The Revenge of Michael Myers | - | - | - | $10,598,777 | 1,495 | $11,642,254 | Oct 13 | - | false |
| 8 | The Fabulous Baker Boys | - | - | - | $9,760,268 | 860 | $18,428,904 | Oct 13 | Twentieth Century Fox | false |
| 9 | Parenthood | - | - | - | $9,549,482 | 1,399 | $100,047,830 | Aug 2 | Universal Pictures | false |
| 10 | Next of Kin | - | - | - | $8,661,770 | 1,358 | $15,942,628 | Oct 20 | Warner Bros. | false |
| 11 | Sex, Lies, and Videotape | - | - | - | $8,394,754 | 534 | $24,741,667 | Aug 4 | Miramax | false |
| 12 | Honey, I Shrunk the Kids | - | - | - | $7,096,618 | 1,498 | $130,724,172 | Jun 23 | Walt Disney Studios Motion Pictures | false |
| 13 | Turner & Hooch | - | - | - | $6,435,607 | 1,888 | $71,079,915 | Jul 28 | Walt Disney Studios Motion Pictures | false |
| 14 | Johnny Handsome | - | - | - | $6,303,625 | 813 | $7,237,794 | Sep 29 | TriStar Pictures | false |
| 15 | Lethal Weapon 2 | - | - | - | $6,147,064 | 1,830 | $147,253,986 | Jul 7 | Warner Bros. | false |
| 16 | Gross Anatomy | - | - | - | $5,161,616 | 1,080 | $11,604,598 | Oct 20 | Walt Disney Studios Motion Pictures | false |
| 17 | Shocker | - | - | - | $4,232,350 | 1,795 | $16,554,699 | Oct 27 | Universal Pictures | false |
| 18 | Kickboxer | - | - | - | $3,909,186 | 973 | $14,697,005 | Sep 8 | Cannon Film Distributors | false |
| 19 | The Abyss | - | - | - | $3,624,733 | 1,538 | $54,222,310 | Aug 11 | Twentieth Century Fox | false |
| 20 | Old Gringo | - | - | - | $3,574,256 | 237 | $3,574,256 | Oct 6 | Columbia Pictures | false |
| 21 | The Bear | - | - | - | $3,471,475 | 1,056 | $31,753,898 | Oct 27 | TriStar Pictures | false |
| 22 | A Dry White Season | - | - | - | $3,459,921 | 316 | $3,766,879 | Sep 20 | Metro-Goldwyn-Mayer (MGM) | false |
| 23 | Batman | - | - | - | $3,321,794 | 2,201 | $251,188,924 | Jun 23 | Warner Bros. | false |
| 24 | Crimes and Misdemeanors | - | - | - | $3,291,453 | 525 | $18,254,702 | Oct 13 | Orion Pictures | false |
| 25 | Fat Man and Little Boy | - | - | - | $2,834,522 | 843 | $3,563,162 | Oct 20 | Paramount Pictures | false |
| 26 | Breaking In | - | - | - | $1,877,618 | 400 | $1,877,618 | Oct 13 | The Samuel Goldwyn Company | false |
| 27 | In Country | - | - | - | $1,610,635 | 606 | $3,531,971 | Sep 15 | Warner Bros. | false |
| 28 | Immediate Family | - | - | - | $1,560,230 | 836 | $5,932,613 | Oct 27 | Columbia Pictures | false |
| 29 | Worth Winning | - | - | - | $1,414,600 | 1,260 | $3,690,328 | Oct 27 | Twentieth Century Fox | false |
| 30 | Romero | - | - | - | $1,297,668 | 51 | $1,316,495 | Aug 25 | Four Square | false |
| 31 | Ghostbusters II | - | - | - | $1,139,671 | 2,410 | $112,494,738 | Jun 16 | Columbia Pictures | false |
| 32 | The Music Teacher | - | - | - | $1,057,934 | 19 | $1,086,894 | Jul 7 | Orion Classics | false |
| 33 | Dad | - | - | - | $542,270 | 1,188 | $22,103,037 | Oct 27 | Universal Pictures | false |
| 34 | Erik the Viking | - | - | - | $405,544 | 269 | $1,932,642 | Sep 22 | Orion Pictures | false |
| 35 | Kill Me Again | - | - | - | $217,681 | 221 | $283,694 | Oct 27 | - | false |
| 36 | Heavy Petting | - | - | - | $156,606 | 11 | $272,371 | Sep 22 | Skouras Pictures | false |
| 37 | When the Whales Came | - | - | - | $73,131 | 10 | $73,131 | Oct 20 | Twentieth Century Fox | false |
| 38 | Thelonious Monk: Straight, No Chaser | - | - | - | $53,688 | 11 | $518,918 | Oct 1 | Warner Bros. | false |
| 39 | Drugstore Cowboy | - | - | - | $48,432 | 87 | $4,729,352 | Oct 6 | Avenue Pictures Productions | false |
| 40 | Animal Behavior | - | - | - | $24,235 | 24 | $41,526 | Oct 27 | Miramax | false |
| 41 | For All Mankind | - | - | - | $3,380 | 9 | $770,132 | Nov 1 | Apollo Associates | false |
