| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Iron Man 2 | - | - | - | $1,834,620 | 61 | $1,862,616 | Apr 29 | Paramount Pictures International | false |
| 2 | Robin Hood | - | - | - | $839,751 | 46 | $995,267 | May 13 | Universal Pictures International (UPI) | false |
| 3 | A Nightmare on Elm Street | - | - | - | $729,040 | 39 | $770,114 | May 6 | Warner Bros. | false |
| 4 | Clash of the Titans | - | - | - | $695,822 | 67 | $2,949,559 | Apr 15 | Warner Bros. | false |
| 5 | Prince of Persia: The Sands of Time | - | - | - | $591,175 | 58 | $1,845,122 | May 27 | Walt Disney Pictures | false |
| 6 | Garfield's Pet Force | - | - | - | $506,300 | 16 | $644,106 | May 13 | - | false |
| 7 | Date Night | - | - | - | $308,082 | 28 | $426,137 | May 13 | 20th Century Fox International | false |
| 8 | The Bounty Hunter | - | - | - | $245,777 | 29 | $267,888 | May 6 | Sony Pictures Releasing | false |
| 9 | The Fourth Kind | - | - | - | $184,452 | 16 | $322,654 | May 20 | - | false |
| 10 | Remember Me | - | - | - | $152,911 | 20 | $162,659 | May 13 | - | false |
| 11 | How to Train Your Dragon | - | - | - | $140,970 | 59 | $1,640,894 | Mar 25 | Paramount Pictures International | false |
| 12 | Spread | - | - | - | $88,105 | 9 | $97,928 | Apr 29 | - | false |
| 13 | Not Forgotten 2010 Re-release | - | - | - | $79,997 | 18 | $88,311 | May 13 | - | false |
| 14 | Two Lovers | - | - | - | $55,444 | 10 | $78,914 | May 20 | - | false |
| 15 | Dear John | - | - | - | $53,728 | 11 | $142,444 | Apr 22 | Sony Pictures Releasing | false |
| 16 | Halloween II | - | - | - | $48,916 | 18 | $123,877 | Apr 22 | - | false |
| 17 | Passengers | - | - | - | $43,902 | 14 | $43,902 | May 6 | - | false |
| 18 | Love Happens | - | - | - | $39,986 | 16 | $86,093 | May 27 | - | false |
| 19 | While She Was Out | - | - | - | $24,868 | 15 | $88,794 | May 27 | - | false |
| 20 | Legion | - | - | - | $22,029 | 27 | $501,215 | Apr 1 | Sony Pictures Releasing | false |
| 21 | Eden Lake | - | - | - | $21,590 | 16 | $121,056 | Mar 25 | - | false |
| 22 | The Book of Eli | - | - | - | $19,826 | 25 | $273,559 | Apr 8 | Sony Pictures Releasing | false |
| 23 | The Blind Side | - | - | - | $17,699 | 18 | $354,112 | Mar 25 | Warner Bros. | false |
| 24 | It's Complicated | - | - | - | $17,329 | 30 | $340,884 | Apr 1 | Universal Pictures International (UPI) | false |
| 25 | The True Story of Puss'N Boots | - | - | - | $17,194 | 20 | $144,875 | Feb 25 | - | false |
| 26 | Avatar | - | - | - | $15,838 | 72 | $5,200,137 | Dec 17 | 20th Century Fox International | false |
| 27 | Did You Hear About the Morgans? | - | - | - | $14,122 | 22 | $131,671 | Mar 18 | Sony Pictures Releasing | false |
| 28 | Let the Right One In | - | - | - | $9,639 | 15 | $145,018 | Apr 1 | - | false |
| 29 | The Lost City 2010 Re-release | - | - | - | $9,618 | 10 | $21,393 | Apr 22 | - | false |
| 30 | Case 39 | - | - | - | $8,370 | 34 | $233,664 | Apr 8 | Paramount Pictures International | false |
| 31 | Extraordinary Measures | - | - | - | $8,169 | 11 | $64,810 | Mar 11 | Sony Pictures Releasing | false |
| 32 | Transsiberian | - | - | - | $6,275 | 6 | $31,795 | Apr 8 | - | false |
| 33 | Alice in Wonderland | - | - | - | $5,764 | 53 | $1,825,228 | Mar 4 | Walt Disney Pictures | false |
| 34 | The Box | - | - | - | $5,541 | 16 | $67,629 | Mar 4 | - | false |
| 35 | My Best Friend's Girl | - | - | - | $3,780 | 27 | $279,926 | Mar 18 | - | false |
| 36 | Paraiso: Tatlong kwento ng pag-asa 2010 Re-release | - | - | - | $3,344 | 5 | $15,406 | Apr 15 | - | false |
| 37 | Paris 36 | - | - | - | $2,897 | 5 | $31,221 | Apr 8 | - | false |
| 38 | Everybody's Fine | - | - | - | $2,719 | 11 | $38,501 | Mar 11 | Walt Disney Pictures | false |
| 39 | When in Rome | - | - | - | $2,620 | 10 | $39,248 | Mar 25 | Walt Disney Pictures | false |
| 40 | Armored | - | - | - | $928 | 26 | $114,780 | Feb 4 | Sony Pictures Releasing | false |
| 41 | Precious | - | - | - | $478 | 7 | $106,931 | Feb 25 | - | false |
| 42 | 9 | - | - | - | $284 | 20 | $67,368 | Feb 18 | - | false |
| 43 | El ratón Pérez 2 | - | - | - | $234 | 27 | $78,160 | Feb 4 | Walt Disney Pictures | false |
| 44 | The Hurt Locker | - | - | - | $93 | 15 | $362,288 | Feb 18 | - | false |
| 45 | Rehenes | - | - | - | $15 | 3 | $1,702 | Apr 29 | - | false |
